In vivo delivery of BCNU from a MEMS device to a tumor model

Li, Yawen; Duc, Hong Linh Ho; Tyler, Betty; Williams, Todd A.; Tupper, Malinda M.; Langer, Robert; Brem, Henry; Cima, Michael J.

doi:10.1016/j.jconrel.2005.04.009

Cited by 90 publications

(49 citation statements)

References 15 publications

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“…Such micro-sized particles were studied, for example, by Tao and Desai, who developed microfabrication as controlled delivery devices [50]. These devices provide the capacity to target cells, promote unidirectional controlled release, and enhance permeation across the intestinal epithelial barrier [50][51][52]. Another application of microparticles are biosensors and for size exclusion chromatography [52,53].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

Bukowska¹,

Bukowski²,

Hus³

et al. 2017

Express Polym. Lett.

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Abstract. In this study, Fe 3 O 4 nanoparticles (NPs) were functionalized with copolymer or terpolymer bearing glycidyl methacrylate (GMA) moieties making them suitable for potential applications as drug delivery systems (DDS). For this purpose, the surface of magnetic nanoparticles was first coated with 3-(trimethoxysilyl) propyl methacrylate (MPS) by a silanization reaction to introduce reactive methacrylate groups onto the surface. Subsequently, monomers were grafted onto the surface of modified-MPS particles via two polymerization methods: seed emulsion (GMA, divinylbenzene, DVB, and styrene, S) and distillation -precipitation (GMA and DVB). The obtained nanocomposite particles were characterized by FTIR (Fourier transform infrared spectroscopy), DR UV-Vis (diffuse reflectance ultraviolet -visible spectroscopy), TEM (transmission electron microscopy) combined with EDS (energy dispersive X-ray spectroscopy) analysis and DLS (dynamic light scattering). FTIR spectroscopy showed that indeed a polymer -Fe 3 O 4 @MPS composite was obtained. TEM and EDS analysis showed that the seed emulsion method resulted in nanosized, 100 nm Fe 3 O 4 @MPS core/polymer shell NPs, forming long chains. On the contrary, the distillation -precipitation method caused the formation of an inverted structure, i.e. polymer core coated by a Fe 3 O 4 @MPS shell, which exhibited a very coarse size distribution varying from several hundreds to over 2 µm.

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Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

Bukowska¹,

Bukowski²,

Hus³

et al. 2017

Express Polym. Lett.

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“…To create the high volume macro-reservoir a scalpel patterned PDMS spacer was placed between the upper silicon chip and the lower Pyrex support. The approach is based on that developed by Li et al (2005) who used a similar approach to create a Pyrex macro-reservoir. The use of PDMS here however allows us to simplify device fabrication (by eliminating hydrofluoric acid based glass etching or machining steps) and facilitate assembly (by eliminating wafer bonding steps).…”

Section: Device Fabrication and Assemblymentioning

confidence: 99%

A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release

Chung

Huh

Erickson

2009

Biomed Microdevices

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Micro-electro-mechanical-system (MEMS) based implantable drug delivery devices represent a promising approach to achieving more precise dosing, faster release and better localization of therapeutic compounds than is possible with existing technology. Despite recent advancements, there remain challenges in being able to build systems that enable active control over the dose rate and release time, in a robust, low power but simple to fabricate package. Here we demonstrate an implantable micro-reservoir device that enables delivery of dose volumes as high as 15 microl using an electrochemically based transport mechanism. This approach allows for a significant reduction in the amount of time required for drug delivery as well as reducing the dependence on the external physiological conditions. We present the overall design, operating principle and construction of the device, and experimental results showing the volume transport rate as a function of the strength of the applied electric field. The concentration profile vs. time, the power consumption, and ejection efficiency are also investigated. To demonstrate the medical utility of the device we also characterize the in-vitro release of vasopressin.

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“…In particular, drugs delivered with conventional methods such as injection can be used in these implantable BioMEMS devices. These drug formulations can take the form of nanoparticle formulations for cancer therapy [9] to intravenous formulations [10,11] and even other potent substances such as hormones or painkillers [12]. Moreover, sensors can be incorporated into these BioMEMS devices where they can monitor the drug release profile and provide useful information for bioengineers and clinicians to optimize the drug therapy for the patients [8].…”

Section: Introductionmentioning

confidence: 99%

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Tng

Song

et al. 2012

Micromachines

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Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

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In vivo delivery of BCNU from a MEMS device to a tumor model

Cited by 90 publications

References 15 publications

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

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