Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Tng, Danny Jian Hang; Hu, Rui; Song, Peiyi; Roy, Indrajit; Yong, Ken‐Tye

doi:10.3390/mi3040615

Cited by 53 publications

(38 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Application examples include continuous pressure monitoring (Mokwa, 2007;Gembaczka et al, 2013), nerve and muscle stimulation (Eick et al, 2009) and drug delivery systems (Hang Tng et al, 2012). Usually medically approved micro-electronic implants such as pacemakers (Park and Lakes, 2007), cochlear implants (Loeb, 1990) or brain stimulators (Rezai et al, 2002) are encapsulated by non-flexible materials such as titanium or ceramics with considerable sidewall thickness in the range of 100 µm to 1 mm.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of implantable integrated MEMS pressure sensors using polyimide epoxy composite and atomic layer deposition

Gembaczka¹,

Görtz²,

Celik³

et al. 2014

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

Abstract. Implantable MEMS sensors are an enabling technology for diagnostic analysis and therapy in medicine. The encapsulation of such miniaturized implants remains a largely unsolved problem. Medically approved encapsulation materials include titanium or ceramics; however, these result in bulky and thick-walled encapsulations which are not suitable for MEMS sensors. In particular, for MEMS pressure sensors the chip surface comprising the pressure membranes must be free of rigid encapsulation material and in direct contact with tissue or body fluids. This work describes a new kind of encapsulation approach for a capacitive pressure sensor module consisting of two integrated circuits. The micromechanical membrane of the pressure sensor may be covered only by very thin layers, to ensure high pressure sensitivity. A suitable passivation method for the high topography of the pressure sensor is atomic layer deposition (ALD) of aluminium oxide (Al 2 O 3 ) and tantalum pentoxide (Ta 2 O 5 ). It provides a hermetic passivation with a high conformity. Prior to ALD coating, a high-temperature resistant polyimide-epoxy composite was evaluated as a die attach material and sealing compound for bond wires and the chip surface. This can sustain the ALD deposition temperature of 275 • C for several hours without any measurable decomposition. Tests indicated that the ALD can be deposited on top of the polyimide-epoxy composite covering the entire sensor module. The encapsulated pressure sensor module was calibrated and tested in an environmental chamber at accelerated aging conditions. An accelerated life test at 60 • C indicated a maximum drift of 5 % full scale after 1482 h. From accelerated life time testing at 120 • C a maximum stable life time of 3.3 years could be extrapolated.

show abstract

Section: Introductionmentioning

confidence: 99%

Encapsulation of implantable integrated MEMS pressure sensors using polyimide epoxy composite and atomic layer deposition

Gembaczka¹,

Görtz²,

Celik³

et al. 2014

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

show abstract

“…Since an external power source is not required, it is possible to for such devices to have minimal footprint. [ 13 ] However, the drug release mechanisms often limit performance to low release rates and slow response. [ 14 ] The drug delivery rate is pre-determined by the selected materials, fabrication methods, or drug formulation, and is highly dependent on the properties of the fl uid transported and the delivery site's environmental properties (e.g., temperature, pH, saccharide concentration, and antigen concentration) that fl uctuate over the course of treatment.…”

Section: Non-powered Mems Drug Delivery Devicesmentioning

confidence: 99%

MEMS: Enabled Drug Delivery Systems

Cobo

Sheybani

Meng

2015

Adv Healthcare Materials

View full text Add to dashboard Cite

Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

show abstract

“…The active devices are reservoir-based drug delivery devices; they contain an actuator due which the device is able to perform active operation [41]. Active devices can be refillable which eliminates the need for a very large reservoir moreover active devices can be tuned according to the particular need of the patient [40]. Passive devices release drugs in a more controlled way and they rely on diffusion process for release of the drug.…”

Section: Implantable Devices For Drug Deliverymentioning

confidence: 99%

“…Implantable devices are designed for applications -in vivo and in vitro [39], [40]. The current trends in the technology which focus on developing a wireless system for energy and data transmission facilitate the in vivo application of these devices.…”

Section: Implantable Devices For Drug Deliverymentioning

confidence: 99%

Current Trends in MEMS Drug Delivery Techniques

Ullah¹,

Kaw²,

Rasool³

et al. 2017

IJET

View full text Add to dashboard Cite

Abstract-The popularisation of the microsystems has paved a way for the evolution of a new class of controlled drug delivery devices which allow tailored delivery of drugs. Additionally, these drug delivery systems enhance efficiency and patient consent. Developing better drug delivery methods is the prime target of the pharmaceutical companies worldwide. The process of drug delivery is as essential as the drug's activity in deciding its effectiveness. These drug delivery systems do not simply release the drug but disseminate the drug in a peculiar manner in accordance to which it has been engineered. Although in their initial stages, the microelectromechanical systems (MEMS) demonstrate the immense potential for conquering the various challenges that are faced by the present drug delivery techniques. Microneedles, micropumps, microvalves, and implantable drug delivery systems have been developed using microfabrication techniques. Several microdevices have been engineered such that they deliver multiple drugs with different dosages in series or parallel which provide several advantages such as extension in the variety of the desirable compounds and precise dosing. Transdermal drug delivery through microneedles enables enhanced permeation through skin layers into the body. Multilayer patch systems lead to an excellent approach in the oral drug delivery. This review examines various MEMS drug delivery techniques along with their diverse benefits.

show abstract

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Cited by 53 publications

References 80 publications

Encapsulation of implantable integrated MEMS pressure sensors using polyimide epoxy composite and atomic layer deposition

Encapsulation of implantable integrated MEMS pressure sensors using polyimide epoxy composite and atomic layer deposition

MEMS: Enabled Drug Delivery Systems

Current Trends in MEMS Drug Delivery Techniques

Contact Info

Product

Resources

About