In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array

Daum, D.R.; Smith, Nadine Barrie; King, Randy L.; Hynynen, Kullervo

doi:10.1016/s0301-5629(99)00053-8

Cited by 123 publications

(71 citation statements)

References 50 publications

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“…The minimally invasive nature of high intensity focused ultrasound (HIFU) has been a focus of different therapeutic applications recently, especially tumor ablation [Sanghvi et al, 1999, He et al, 2001, Chapelon et al, 1999, Daum et al, 1999, ter Haar, 2001, Wu et al, 2001. However, in some cases the lesions were not formed as expected, either in shape, or in location relative to the geometric focus [Watkin et al, 1996.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of lesion formation in high intensity focused ultrasound therapy

Chen

Lafon

Matula

et al. 2003

Acoustics Research Letters Online

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Section: Introductionmentioning

confidence: 99%

Mechanisms of lesion formation in high intensity focused ultrasound therapy

Chen

Lafon

Matula

et al. 2003

Acoustics Research Letters Online

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“…To date, the challenges in integrating these technologies has been the lack of MRI-compatible equipment for ultrasound imaging, but recent developments in piezocomposite materials [20] as well as non-magnetic motors has made this integration feasible. This study demonstrated the capability to perform ultrasound imaging in a clinical MR imager with a mechanically scanned transducer during MR image acquisition.…”

Section: Discussionmentioning

confidence: 99%

Progress in Multimodality Imaging: Truly Simultaneous Ultrasound and Magnetic Resonance Imaging

Curiel

Chopra

Hynynen

2007

IEEE Trans. Med. Imaging

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Multimodality medical imaging takes advantage of the strengths of different imaging modalities to provide a more complete picture of the anatomy under investigation. Many complementary modalities have been combined to form such systems and some are gaining use clinically. One combination that has not been developed, in large part due to technical difficulties, is a combined MR and ultrasound imaging system. Such a system offers the potential to combine the strengths of these modalities in a wide range of diagnostic and therapeutic applications. The goal of this study was to evaluate the feasibility of performing simultaneous multimodality ultrasound and MR imaging. An ultrasound imaging system capable of operation in a clinical MR imager was developed, and methods to perform simultaneous imaging were investigated. Simultaneous imaging was feasible without any mutual interference by either filtering the transmitted and received ultrasound signal, or by synchronizing data acquisition between the two imaging systems. Spatial registration between the two modalities was achieved by using a reference phantom with implanted glass beads in orthogonal planes. Excellent agreement was observed between spatial measurements of an object made with both modalities, and the feasibility of using this system in vivo was demonstrated in a rabbit model. Simultaneous ultrasound and MR imaging is achievable, and can provide complementary information about an object under investigation. This demonstration of technical feasibility and the development of a prototype system open up the potential to investigate the promising clinical applications of this combined technology.

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“…These table-top systems also have demonstrated the feasibility of HIFU in the pig liver [17], [18]. MR images provide three essential functions: (1) anatomical image guidance for placement of the HIFU probe, (2) real-time temperature monitoring using proton resonance frequency shift to target the location and duration of the therapy [19]- [21], and (3) post-process functional assessment to evaluate the degree of tissue necrosis [22].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of MR-temperature mapping of ultrasonic heating from a CMUT

Wong

Watkins

Kupnik

et al. 2008

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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In the last decade, high intensity focused ultrasound (HIFU) has gained popularity as a minimallyinvasive and non-invasive therapeutic tool for treatment of cancers, arrhythmias, and other medical conditions. HIFU therapy is often guided by magnetic resonance imaging (MRI), which provides anatomical images for therapeutic device placement, temperature maps for treatment guidance, and post-operative evaluation of the region of interest. While piezoelectric transducers are dominantly used for MR-guided HIFU, capacitive micromachined ultrasonic transducers (CMUTs) show competitive advantages such as ease of fabrication, integration with electronics, improved efficiency, and reduction of self-heating. In this paper, we will show our first results of an unfocused CMUT transducer monitored by MR-temperature maps. This 2.51 mm by 2.32 mm, unfocused CMUT heated a HIFU phantom by 14°C in 2.5 min. This temperature rise was successfully monitored by MR thermometry in a 3.0 T General Electric scanner. Index Terms

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In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array

Cited by 123 publications

References 50 publications

Mechanisms of lesion formation in high intensity focused ultrasound therapy

Mechanisms of lesion formation in high intensity focused ultrasound therapy

Progress in Multimodality Imaging: Truly Simultaneous Ultrasound and Magnetic Resonance Imaging

Feasibility of MR-temperature mapping of ultrasonic heating from a CMUT

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