Mechanisms of lesion formation in high intensity focused ultrasound therapy

Chen, Wen-Shiang; Lafon, Cyril; Matula, Thomas J.; Vaezy, Shahram; Crum, Lawrence A.

doi:10.1121/1.1559911

Cited by 68 publications

(46 citation statements)

References 16 publications

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“…Such activity can be exploited to visualize ablation effects (Sanghvi et al 1995;Rabkin et al 2005Rabkin et al , 2006 or to enhance tissue absorption (Melodelima et al 2001;Sokka et al 2003;Umemura et al 2005;Kaneko et al 2005), but can also complicate ultrasound energy deposition and the resulting spatial pattern of tissue coagulation (Watkin et al 1996;Chen et al 2003;Makin et al 2005;. Mechanisms for interactions between cavitation activity and ultrasound-induced heating have been clarified by several detailed numerical modeling studies (Hilgenfeldt et al 2000;Chavrier et al 2000;Yang et al 2004) and phantom experiments (Holt and Roy 2001;Khokhlova et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Acoustic Emissions During 3.1 MHz Ultrasound Bulk Ablation In Vitro

Mast

Salgaonkar

Karunakaran

et al. 2008

Ultrasound in Medicine & Biology

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Acoustic emissions associated with cavitation and other bubble activity have previously been observed during ultrasound ablation experiments. Since detectable bubble activity may be related to temperature, tissue state, and sonication characteristics, these acoustic emissions are potentially useful for monitoring and control of ultrasound ablation. To investigate these relationships, ultrasound ablation experiments were performed with simultaneous measurements of acoustic emissions, tissue echogenicity, and tissue temperature, on fresh bovine liver. Ex vivo tissue was exposed to 0.9-3.3 s bursts of unfocused, continuous-wave, 3.10 MHz ultrasound from a miniaturized 32-element array, which performed B-scan imaging with the same piezoelectric elements during brief quiescent periods. Exposures employed pressure amplitudes of 0.8-1.4 MPa for exposure times of 6-20 min, sufficient to achieve significant thermal coagulation in all cases. Acoustic emissions received by a 1 MHz, unfocused passive cavitation detector, beamformed Aline signals acquired by the array, and tissue temperature detected by a needle thermocouple were sampled 0.3-1.1 times per second. Tissue echogenicity was quantified by the backscattered echo energy from a fixed region of interest within the treated zone. Acoustic emission levels were quantified from the spectra of signals measured by the passive cavitation detector, including subharmonic signal components at 1.55 MHz, broadband signal components within the band 0.3-1.1 MHz, and low-frequency components within the band 10-30 kHz. Tissue ablation rates, defined as the thermally ablated volumes per unit time, were assessed by quantitative analysis of digitally imaged, macroscopic tissue sections. Correlation analysis was performed among the averaged and time-dependent acoustic emissions in each band considered, B-mode tissue echogenicity, tissue temperature, and ablation rate. Ablation rate correlated significantly with broadband and low-frequency emissions, but was uncorrelated with subharmonic emissions. Subharmonic emissions were found to depend strongly on temperature in a nonlinear manner, with significant emissions occurring within different temperature ranges for each sonication amplitude. These results suggest potential roles for passive detection of acoustic emissions in guidance and control of bulk ultrasound ablation treatments.

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Section: Introductionmentioning

confidence: 99%

Acoustic Emissions During 3.1 MHz Ultrasound Bulk Ablation In Vitro

Mast

Salgaonkar

Karunakaran

et al. 2008

Ultrasound in Medicine & Biology

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show abstract

“…In the CC study, agargraphite phantoms were used, 1,2,10 while in the VI study, optically transparent acrylamide phantoms with BSA (bovine serum albumin) were employed. [10][11][12] The HIFU pressure was measured in water using a calibrated membrane hydrophone (Precision Acoustics Inc.). The corresponding focal pressure in the phantom followed from a numerical simulation of the nonlinear pressure field given the known acoustical properties of two different gel materials (1560 m/s and 0.182 Np/cm @ 1 MHz for agar-graphite phantoms; 1570 m/s and 0.02 Np/cm @ 2 MHz for acrylamide phantoms 12 ) and the phantom geometry.…”

Section: Experimental Methodsmentioning

confidence: 99%

Dynamics and control of cavitation during high-intensity focused ultrasound application

Thomas

Farny

Coussios

et al. 2005

Acoustics Research Letters Online

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“…Those boiling bubbles could scatter the HIFU waves and attenuate the waves strongly (called "shielding effects"). Additionally, those bubbles could produce unpredictable and uncontrollable tadpole-type lesions [69,70].…”

Section: High Intensity Focused Ultrasound Treatmentmentioning

confidence: 99%

Enhancement of heat and mass transfer by cavitation

Zhang

Xian

2015

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. In this paper, a brief summary of effects of cavitation on the heat and mass transfer are given. The fundamental studies of cavitation bubbles, including its nonlinearity, rectified heat and mass diffusion, are initially introduced. Then selected topics of cavitation enhanced heat and mass transfer were discussed in details including whales stranding caused by active sonar activity, pool boiling heat transfer, oscillating heat pipe and high intensity focused ultrasound treatment.

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Mechanisms of lesion formation in high intensity focused ultrasound therapy

Cited by 68 publications

References 16 publications

Acoustic Emissions During 3.1 MHz Ultrasound Bulk Ablation In Vitro

Acoustic Emissions During 3.1 MHz Ultrasound Bulk Ablation In Vitro

Dynamics and control of cavitation during high-intensity focused ultrasound application

Enhancement of heat and mass transfer by cavitation

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