In vivo EPR spectroscopic imaging for a liposomal drug delivery system

Matsumoto, Shingo; Yahiro, Tomoaki; Yamada, Ken Ichi; Utsumi, Hideo

doi:10.1002/mrm.20460

Cited by 20 publications

(15 citation statements)

References 32 publications

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“…), even though a single nitroxyl contrast agent was used in the experiment. The spectral-spatial EPR imaging technique can be employed to map multiple spectral distributions [19,20], while this technique requires more acquisition time. Spectral information and spatial information are alternatives in those EPR imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of EPR imaging and T1-weighted MRI for efficient imaging of nitroxyl contrast agents

Matsumoto¹,

Narazaki²,

Ikehira³

et al. 2007

Journal of Magnetic Resonance

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Section: Introductionmentioning

confidence: 99%

Comparisons of EPR imaging and T1-weighted MRI for efficient imaging of nitroxyl contrast agents

Matsumoto¹,

Narazaki²,

Ikehira³

et al. 2007

Journal of Magnetic Resonance

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“…Another option is to encapsulate nitroxides in lipophilic environments. As oxygen is more soluble in organic solvents than in water, an increase in sensitivity has been demonstrated using these systems [95,96] .…”

Section: Macromolecular Conjugatesmentioning

confidence: 98%

Spin probes for electron paramagnetic resonance imaging

et al. 2008

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“…With this method, 2D distributions of hydroxyl radical trapped by DMPO (DMPO-OH) and nitric oxide trapped by Fe 2ϩ -MGD (Fe 2ϩ -MGD-NO) in a phantom were successfully separated. The same method was applied to observe the fates of highly concentrated (300 mM) CAT-1 solution encapsulated in liposomes and a free 2 mM CAT-1 solution injected in mice (72). The location of anthralin radical caused in mouse skin by UV-A irradiation was calculated from the location of DPPH radical as a landmark in a microscopic 2D EPR spectral-spatial image at X-band (73).…”

Section: Matsumoto Et Al 1132mentioning

confidence: 99%

Spatially Resolved Biologic Information from In Vivo EPRI, OMRI, and MRI

Matsumoto

Subramanian

Murugesan

et al. 2007

Antioxidants & Redox Signaling

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EPR spectroscopy can give biologically important information, such as tissue redox status, pO2, pH, and microviscosity, based on variation of EPR spectral characteristics (i.e., intensity, linewidth, hyperfine splitting, and spectral shape of free radical probes. EPR imaging (EPRI) can obtain 1D-3D spatial distribution of such spectral components using several combinations of magnetic field gradients. Overhauser enhanced MRI (OMRI) is a double-resonance technique of electron and nuclear spins. Because the Overhauser enhancement depends on transverse relaxation rate of the electron spin, OMRI can provide pO2 information indirectly, along with a high-resolution MR image. MRI can also indirectly detect paramagnetic behaviors of free radical contrast agents. Imaging techniques and applications relating to paramagnetic species (i.e., EPRI, OMRI, and MRI) have the potential to obtain maximally 5D information (i.e., 3D spatial + 1D spectral + 1D temporal dimensions, theoretically). To obtain suitable dimensionality, several factors, such as the EPR spectral information, spatial resolution, temporal resolution, will have to be taken into account. For this review, the EPRI, OMRI, and MRI applications for the study biological systems were evaluated for researchers to apply the method of choice and the mode of measurements to specific experimental systems.

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In vivo EPR spectroscopic imaging for a liposomal drug delivery system

Cited by 20 publications

References 32 publications

Comparisons of EPR imaging and T1-weighted MRI for efficient imaging of nitroxyl contrast agents

Comparisons of EPR imaging and T1-weighted MRI for efficient imaging of nitroxyl contrast agents

Spin probes for electron paramagnetic resonance imaging

Spatially Resolved Biologic Information from In Vivo EPRI, OMRI, and MRI

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