In vivo evaluation of antimicrobial, antipyretic, analgesic, and anti-inflammatory activities of Nilavembu Kudineer capsule in comparison with siddha classical Nilavembu Kudineer

Lekha, G. S.; Deepika, E; Swetha, S.; Kanagarajan, A; Gayathridevi, V; Santhy, K. S.

doi:10.4103/pr.pr_23_20

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…This is mainly attributed to the difference in their cell wall composition and thickness. The presence of the peptidoglycan layer in Gram-positive bacteria makes them more sensitive to plant extracts, which are permeable to the extracts [32] .…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Ekambaram¹,

Santhy²

2022

IJPS

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Hygrophila auriculata is a thorny sub-shrub of the family Acanthaceae. It is a potent medicinal plant in the Indian systems of medicine with various therapeutic uses, from simple management of infections to treatment of diseases. The present study was conducted to investigate the phytochemical and pharmacological properties of the leaves of Hygrophila auriculata. The screening of various phytochemicals was performed using a standard procedure and the characterization was analyzed with spectral studies. The pharmacological investigation includes antioxidant and antimicrobial activities of the extract. Antioxidant activity was carried out using 2, 2-diphenylpicrylhydrazyl free radical scavenging assay and reducing power assay. Antimicrobial activity was done by the agar well diffusion method. The phytochemical screening detected alkaloids, flavonoids, terpenoids, tannins, carbohydrates and saponins. The 2,2-diphenylpicrylhydrazyl antioxidant assay reveals that the extract had a considerable scavenging capacity. It was found that the reducing power of different concentrations of the leaf extract was remarkable. Antimicrobial tests revealed that the leaf extract was active against selected Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) and few fungal species (Aspergillus sp.). These findings disclosed that the Hygrophila auriculata leaves have various phytotherapeutic activities and the compounds identified using the gas chromatography were responsible for the above activities. Thus, it would be helpful to isolate the compounds responsible for the bioactivities in the future for treatment of various ailments.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Ekambaram¹,

Santhy²

2022

IJPS

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“…The antibacterial study results indicated that Nilavembu Choornam polyherbal decoction (NCt; 20 µL/disc) exhibited less antimicrobial activity against antibiotic-resistant bacteria and had more resistance when compared to the non-resistant bacterial growth inhibition. In a previous study it was reported that a Nilavembu Kudineer capsule (200 mg/kg) has very effective antimicrobial, analgesic, and antipyretic potential, exhibiting a higher level of zone of inhibition against S. aureus, S. flexneri, P. aeruginosa, P. vulgaris, and K. pneumonia, together with decreased inflammatory markers, including cyclooxygenase and prostaglandins, and also reduced proinflammatory markers IL-6 and IL-1 [42]. Studies showed that the presence of the peptidoglycan layer in Gram-positive bacteria makes them more permeable to plant extracts [43,44].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Nilavembu Choornam–Gold Nanoparticles on Antibiotic-Resistant Bacterial Susceptibility and Contact Lens Contamination-Associated Infectious Pathogenicity

Almutleb,

Ramachandran,

Khan

et al. 2024

IJMS

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Antibiotic-resistant bacterial colonies mitigate rapid biofilm formation and have complex cell wall fabrications, making it challenging to penetrate drugs across their biofilm barriers. The objective of this study was to investigate the antibacterial susceptibility of antibiotic-resistant bacteria and contact lens barrenness. Nilavembu Choornam–Gold Nanoparticles (NC–GNPs) were synthesized using NC polyherbal extract and characterized by UV-visible spectrophotometer, SEM-EDX, XRD, Zeta sizer, FTIR, and TEM analysis. Contact lenses with overnight cultures of antibiotic-resistant bacteria K. pneumoniae and S. aureus showed significant differences in growth, biofilm formation, and infection pathogenicity. The NC–GNPs were observed in terms of size (average size is 57.6 nm) and surface chemistry. A zone of inhibition was calculated for K. pneumoniae 18.8 ± 1.06, S. aureus 23.6 ± 1.15, P. aeruginosa 24.16 ± 0.87, and E. faecalis 24.5 ± 1.54 mm at 24 h of NC–GNPs alone treatment. In electron microscopy studies, NC–GNP-treated groups showed nuclear shrinkage, nuclear disintegration, degeneration of cell walls, and inhibited chromosomal division. In contrast, normal bacterial colonies had a higher number of cell divisions and routinely migrated toward cell multiplications. NC–GNPs exhibited antibacterial efficacy against antibiotic-resistant bacteria when compared to NC extract alone. We suggest that NC–GNPs are highly valuable to the population of hospitalized patients and other people to reduce the primary complications of contact lens contamination-oriented microbial infection and the therapeutic efficiency of antibiotic-resistant bacterial pathogenicity.

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“…In addition to anti-DENV potentials, Nilavembu Kudineer has been found to have many pleiotropic effects such as antipyretic, analgesic, anti-inflammatory, and antioxidant properties, which would help the patients with DF to alleviate their signs and symptoms [35], [36]. The levels of pain and fever significantly decreased in patients who received Nilavembu Kudineer, according to a quasi-experimental design clinical study of 60 participants [37].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Nilavembu Kudineer for Dengue Fever Management – An Overview of Clinical and Preclinical Evidences

Maideen

2023

SEE J Immunol

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BACKGROUND AND AIM: Dengue viral disease (DVD) is a tropical arboviral disease that is caused by dengue virus (DENV), which is transmitted mainly by the bite of female Aedes aegypti mosquitoes. No specific antiviral drug is approved yet to manage the patients with DENV infection, who are managed using symptomatic therapy and supportive care. AIM: As a consequence, we intend to review the potential of Nilavembu kudineer in the management of DENV infection. MATERIALS AND METHODS: To find articles pertinent to the clinical, in vitro, and in silico studies evaluating the effectiveness of Nilavembu Kudineer in the management of DENV infection, the literature was searched in databases such as Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, Embase, Directory of open access journals, and reference lists. RESULTS: Nilavembu Kudineer may be able to alleviate signs and symptoms experienced by patients with DENV infection, according to few clinical, in vitro, and in silico studies. CONCLUSION: The effectiveness of Nilavembu Kudineer in patients with DENV infection would further be demonstrated by additional randomized controlled clinical trials.

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In vivo evaluation of antimicrobial, antipyretic, analgesic, and anti-inflammatory activities of Nilavembu Kudineer capsule in comparison with siddha classical Nilavembu Kudineer

Cited by 5 publications

References 7 publications

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Synergistic Effect of Nilavembu Choornam–Gold Nanoparticles on Antibiotic-Resistant Bacterial Susceptibility and Contact Lens Contamination-Associated Infectious Pathogenicity

Efficacy of Nilavembu Kudineer for Dengue Fever Management – An Overview of Clinical and Preclinical Evidences

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