In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds

Mohamad, Najwa; Loh, Evelyn Yun Xi; Fauzi, Mh Busra; Ng, Min Hwei; Amin, Mohd Cairul Iqbal Mohd

doi:10.1007/s13346-017-0475-3

Cited by 108 publications

(92 citation statements)

References 42 publications

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“…Because of the possibility to support mammalian cell attachment and proliferation, BC films are also investigated as cell carriers in cell transplantation [102]. For instance, bacterial cellulose/acrylic acid (BC/AA) wound dressing hydrogels (without cells) enhanced wound healing capacity in nude mice.…”

Section: Bc As Cell Carriermentioning

confidence: 99%

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Antón-Sales

Beekmann

Laromaine

et al. 2019

CDT

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In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Because of their continuous exposure to environmental stressors, damage to epithelial tissues is highly prevalent. Here, we first compare the properties of bacterial cellulose to the current gold standard, collagen, and then we examine the use of bacterial cellulose patches to heal specific epithelial tissues; the outer skin, the ocular surface, the oral mucosa and other epithelial surfaces. Special emphasis is made on the dermis since, to date, this is the most widespread medical use of bacterial cellulose. It is important to note that some epithelial tissues represent only the outermost layer of more complex structures such as the skin or the cornea. In these situations, depending on the penetration of the lesion, bacterial cellulose might also be involved in the regeneration of, for instance, inner connective tissue.

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Section: Bc As Cell Carriermentioning

confidence: 99%

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Antón-Sales

Beekmann

Laromaine

et al. 2019

CDT

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“…The resulting composite was then tested in vitro for biocompatibility and cytotoxicity against "Vero cells" and was found to be compatible and non-toxic, thus suggesting its applicability in tissue engineering, as well as wound dressing. 75 In addition to wound healing materials, composites of BC and acrylic acid have also been reported to be able to accelerate the formation of keratin and hair follicles after two weeks of treatment. 55 The composites promote faster wound healing by enhancing the epithelialization process, thus accelerate fibroblast proliferation.…”

Section: Wound Dressingmentioning

confidence: 99%

Overview of Inexpensive Production Routes of Bacterial Cellulose and Its Applications in Biomedical Engineering

Salihu¹,

Foong²,

Razak³

et al. 2019

Cellulose Chem. Technol.

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Bacterial cellulose (BC) is an innovative polymeric nanofibre, which meets the demands of rapidly advancing industries, such as biomedical engineering, food packaging, pulp and paper and electrical appliance engineering. The versatility of bacterial cellulose is largely due to its unique properties, such as high crystallinity, high thermal stability, high water absorption capacity, hydrophilicity, good mechanical strength, biodegradability, high biocompatibility and high porosity, making it well-suited for applications in various fields. In recent years, advances for enhancing the applicability of BC through modification and its inclusion into composites have been in focus. Unfortunately, despite the multiple advantages it offers, the production cost of BC is too high, thus reducing/limiting its commercial attractiveness and industrial scale production. This paper is an overview of the current research trends for developing cheaper BC production pathways and of recent advances performed so far with the prospect of enhancing its potential application in biomedical engineering.

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“…On day 13 after wound coverage, the percentage of wound reduction for the hydrogel loaded with cells, for the pure hydrogel and for the control untreated group of animals were about 77%, 72% and 65%, respectively. The transferred cells are believed to assist in initiating the wound healing process, where the fibroblasts play a role in forming the granulation tissue and the keratinocytes help in re-epithelialization [221]. Wound healing and lactate dehydrogenase in the blood serum [226].…”

Section: Nanocellulose As a Carrier For Cell Delivery Into Skin Defectsmentioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

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In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds

Cited by 108 publications

References 42 publications

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Overview of Inexpensive Production Routes of Bacterial Cellulose and Its Applications in Biomedical Engineering

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

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