In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs

Khaled, Khaled A.; Asiri, Yousif A.; El–Sayed, Y. M.

doi:10.1016/s0378-5173(01)00633-0

Cited by 59 publications

(36 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Khaled et al (30) Evaluation of liquisolid tablets containing famotidine showed a higher dissolution rate than the conventional, directly compressed tablets. Liquisolid formulation released 78 % of famotidine during the first 10 min, which is 39 % more than the release from directly compressed tablets (32).…”

Section: Advantages Limitations and Application Of Liquisolid Systemsmentioning

confidence: 99%

Liquisolid systems and aspects influencing their research and development

Vraníková¹,

Gajdziok²

2013

Acta Pharmaceutica

View full text Add to dashboard Cite

show abstract

Section: Advantages Limitations and Application Of Liquisolid Systemsmentioning

confidence: 99%

Liquisolid systems and aspects influencing their research and development

Vraníková¹,

Gajdziok²

2013

Acta Pharmaceutica

View full text Add to dashboard Cite

show abstract

“…It was observed that liquisolid tablets displayed significantly enhanced dissolution profiles compared to marketed products. Further the technology was utilized by Khaled et al, to evaluate the absorption characteristics of experimentally developed hydrochlorothiazide liquisolid tablets using six male beagle dogs (34). The drug was administered orally as a single dose (25mg) of commercial and liquisolid tablets, and pharmacokinetic parameters (post intravenous dosing) were reported for the first time.…”

Section: From Initiation Of the Concept To 2007mentioning

confidence: 99%

Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field

Sharma

Pathak

2016

mazums-pbr

View full text Add to dashboard Cite

“…Ali et al (2005) found that, from the indomethacin liquisolid tablets, the amount of drug release at pH 7.2 is greater than that released at pH 1.2 due to the higher solubility of indomethacin at higher pH values. Khaled et al (2001) reported that hydrochlorothiazide liquisolid tablets showed significantly greater extent of absorption than commercial tablets. Therefore, this formulation of the drug has the potential to be considered for human study in order to be manufactured on a large scale.…”

Section: Pre Compression Studiesmentioning

confidence: 99%

The Liquisolid technique: an overview

Burra¹,

Yamsani²,

Venkateswarlu³

2011

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles.Uniterms: Liquisolid. Solubility. Bioavailability. Flow properties. Load factor. Powder solution technology.A nova "Tecnologia da Solução Sólida" envolve eficiência de absorção e de adsorção, faz uso de medicações líquidas, suspensões de fármacos e misturas com transportadores adequados, materiais de cobertura e é formulada em formas sólidas em fluxo livre, secas, não aderentes e compressíveis. Com base em novo modelo matemático, características aprimoradas de fluxo e dureza da formulação foram alcançadas modificando-se a proporção de Avicel ® PH 200 e Aerosil ® PH 200 de 50:1 para 5:1, na qual o fármaco é disperso quase que no estado molecular. Devido às propriedades de umidificação significativamente aprimoradas e à área do fármaco exposta ao meio de dissolução, que resulta na velocidade de dissolução, a biodisponibilidade foi aumentada. Utilizando a técnica Liquisólido, desenvolveram-se sistemas de liberação controlada de fármacos solúveis em água, nos quais solventes hidrofóbicos não voláteis foram usados como veículos.Unitermos: Liquisólido. Solubilidade. Biodisponibilidade. Propriedades de fluxo. Fator de carga. Tecnologia de solução sólida.

show abstract

In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs

Cited by 59 publications

References 6 publications

Liquisolid systems and aspects influencing their research and development

Liquisolid systems and aspects influencing their research and development

Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field

The Liquisolid technique: an overview

Contact Info

Product

Resources

About