In vivo evaluation of hypolipidemic and antioxidative effect of ‘Ajwa’ (Phoenix dactylifera L.) date seed-extract in high-fat diet-induced hyperlipidemic rat model

Khan, Tariq Jamal; Kuerban, Abudukadeer; Razvi, Syed Shoeb; Mehanna, Mohamed G.; Khan, Khalid Ali; Almulaiky, Yaaser Q.; Faidallah, Hassan M.

doi:10.1016/j.biopha.2018.07.134

Cited by 40 publications

(25 citation statements)

References 23 publications

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“…The body's antioxidant examination also showed a decrease in catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH) and increased MDA in CCl 4 -induced mice.In hyperlipidaemic mice given atorvastatin, ALT and AST levels were lower with Ajwa seed extract consumption compared to those not given. This shows the ability of inner date palm extract to function as hepatoprotective (14). Consumption of a basal diet together with date seed powder can also reduce AST, GGT, and ALT.…”

Section: Resultsmentioning

confidence: 83%

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Saryono¹,

Proverawati²

2019

ATMPH

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Background: Most toxic substances in the body are metabolized in the liver, so it's giving a hepatotoxic effect. This review aimed to examine the effects of consumption of date seeds in liver protection. Method: This research uses a systematic review design. Articles search is systematically carried out on the relevant publication databases such as Google Scholar, PubMed and DOAJ. The keywords used are "hepatoprotective", "date seed", and "date pits". Publication articles are limited between 2014 -2019. All applicable studies were evaluated based on titles and abstracts, then continued to the content. Results: we found 44 data sets of a total of 218 articles identified. Based on the inclusion criteria and critical assessment of the article, only 10 articles are in accordance with this review. Conclusion: Date seeds contain antioxidants that significantly increase antioxidant activity, reduce free radicals and improve liver enzymes and tissues.

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Section: Resultsmentioning

confidence: 83%

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Saryono¹,

Proverawati²

2019

ATMPH

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“…In agreement with our findings, Al‐Yahya et al () observed that Ajwa date extract reduced the cholesterol, LDL‐C, and VLDL‐C level in serums of rats treated with isoproterenol, demonstrating the robust effect of Ajwa date extract on the serum lipid profile. In addition, Khan et al () reported that Ajwa seed extracts (1,000 mg/kg) reduced the level of serum cholesterol in hyperlipidemic rat model. Pande and Srinivasan () also reported that addition of cluster beans and garlic or their mixtures to a high‐cholesterol diet promoted significant hypolipidemic effects as they reduced cholesterol, triglyceride, LDL‐C, VLDL‐C, and AI and increased the HDL‐C content of rat serum.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and antihyperlipidemic effects of Ajwa date (Phoenix dactyliferaL.) extracts in rats fed a cholesterol‐rich diet

et al. 2019

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This study investigated the chemical composition, in vivo antioxidant, and antihyperlipidemic potential of Ajwa date polyphenol extract (DPE). Chemical analysis revealed that the Ajwa dates contain substantial amounts of carbohydrates, energy, potassium, iron, polyphenols, and flavonoids. In vivo studies showed that feeding rats with cholesterol‐rich diets significantly (p ≤ 0.05) increased their body and liver weights, total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), very‐low‐density lipoprotein cholesterol (VLDL‐C), and triglycerides (TG) in plasma and liver, and reduced the high‐density lipoprotein cholesterol (HDL‐C) content and antioxidant enzyme activities. However, oral administration of 25, 50, and 100 mg DPE/kg body weight to hypercholestrolemic rats, significantly (p ≤ 0.05) reduced their body and liver weights, total hepatic cholesterol, LDL‐C, VLDL‐C, and triglycerides. Furthermore, treatment with DPE improved (p ≤ 0.05) the HDL‐C concentration and antioxidant enzyme activity in a concentration‐dependent fashion, thereby regulating lipid profiles, enhancing the antioxidant defense system. Overall, DPE showed significant (p ≤ 0.05) nutritional, antioxidants, and antihyperlipidemic benefits. Practical applications Coronary heart disease is the leading cause of death in the world. Consumption of fruits and vegetables rich in polyphenol have shown to exert cardio‐protective effect. This work revealed that phenolic extracts of Ajwa dates have positive impacts on the health as it reduced TC, LDL‐C, and lipids VLDL‐C and improved HDL‐C and the antioxidant defense system in rats. The findings of this study could aid in the profound understanding of the nutritional and health potentials of Ajwa dates and thus could help in utilization of these valuable fruits for the prevention and curing of cardiovascular diseases.

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“…Phytochemicals in fruits, vegetables and plant parts hold secondary metabolites and their essential metabolites have several inherent biological activities that involve antimicrobial, antiinflammatory and inhibitory enzyme properties with health benefits [30,31]. In our previous studies, avocado and pomegranate juice, peel and seed oil ameliorated toxicity and decreased inflammation, oxidative stress and apoptosis induced by CCl4 and DEN [21,[32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Hamouda¹,

Farawilla²,

Attafi³

et al. 2021

JCMR

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Background: Since 2019, several critical effects of the coronavirus pandemic have surfaced, including its psychological problems such as depression. The World Health Organization has approved a group of drugs and vaccines. However, the world still faces novel coronavirus mutations, requiring more ideas to investigate a drug, vaccine and phytochemical potential chemoprevention proposal. Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV)-2 co-operates directly with the Angiotensin-Converting Enzyme 2 (ACE2) to penetrate the target cells.Aims: We aim to introduce the possibility of studying seed oil extract as an anti-depression, anti-stress, anti-epinephrine receptor (PDB: 2rh1) and as potentially binding anti-angiotensinconverting enzyme 2 (ACE2) agent.

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In vivo evaluation of hypolipidemic and antioxidative effect of ‘Ajwa’ (Phoenix dactylifera L.) date seed-extract in high-fat diet-induced hyperlipidemic rat model

Cited by 40 publications

References 23 publications

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Antioxidant and antihyperlipidemic effects of Ajwa date (Phoenix dactyliferaL.) extracts in rats fed a cholesterol‐rich diet

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

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