In vivo evaluation of matrix granules containing microcrystalline chitosan as a gel-forming excipient

Characterization of Psyllium (Plantago ovata) Polysaccharide and Its Uses

“…Globally, there is a renewed interest in investigating drugs and excipients from natural sources, especially from plant and marine sources that include starches obtained from corn, wheat, rice, and tapioca (Andreev 2004) and different types of essential and aromatic oils. A number of polysaccharides like chitosan (Park et al 2002;Sakkinen et al 2003;Thanou et al 2000), tamarind seed polysaccharide (Gholardi et al 2000;Kulkarni et al 2005;Sumath and Ray 2002;Miyazaki et al 1998), psyllium husk (Fischer et al 2004a), guar gum (George and Abraham 2007), xanthum gum (Attama et al 2006;Khourefieh et al 2007), and rice bran wax (Dolz et al 2007) are currently being used or investigated for varied roles as pharmaceutical excipients which include mucoadhesion, gel former, drug release retardant, plasticizer, thickener, and binder. The investigations to explore and investigate newer and newer plant sources continue unabated despite the availability of a large number of synthetic excipients.…”

Interaction of microcrystalline chitosan (MCCh) with Mo(VI) in aqueous solution

“…For example, a stable hydroxypropylmethylcellulose (HPMC) gel is formed over the pH range 3-11. [4][5][6] The problem of interaction of chitin and chitosan (in both standard and substituted forms) with biologically relevant metal ions has been attracting more and more attention during the last years, parallel to the progress that has been observed in the methods of biocoordination chemistry. [7][8][9][10][11] At the same time, applications of chitosan as a chelating agent to metals and thus removing metal contaminations from water has become of great interest.…”

Ibuprofen-loaded chitosan and chemically modified chitosans—Release features from tablet and film forms

“…So, drug-loaded chitosan or one of its chemical derivatives might provide these advantages for nonsteroidal anti-inflammatory drugs such as ibuprofen that has an amphiphilic character and leads to gastric irritation [10][11][12][13][14]. An encapsulation procedure would avoid various musculoskeletal disorder effects and lead more directly to reduce painful conditions [15].…”

“…This behavior is clearly justified by the fact that 15-30% of patients who utilize these kinds of drugs for a long time have gastrointestinal ulcers and bleeding or renal dysfunction [17]. Thus, the need arises to minimize these adverse effects and to extend its inflammatory action, where the targeted delivery of drug through the use of a matrix, such as chitosan or chitosan derivatives, can help to reduce a series of undesirable side effects [12,15,18].…”