In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis

Choi, In Young; Lee, Phil; Adany, Peter; Hughes, Abbey J.; Belliston, Scott; Denney, Douglas R.; Lynch, Sharon G.

doi:10.1177/1352458517711568

Cited by 78 publications

(66 citation statements)

References 36 publications

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“…Higher levels of oxidative stress markers and lower antioxidant capacity have been found in MS patients. Some mechanisms have been proposed to explain the role of ROS in MS neurological damage including: (i) low levels of antioxidants that stimulate transendothelial leukocyte migration through the BBB breakdown, thus contributing to immunoinflammatory processes in the cerebral cortex; and (ii) excess ROS increasing T cell concentration and producing myelin damage [ 56 , 90 , 91 , 92 ]. Nrf2 is also involved in the progression of MS, although studies with dietary compounds are scarce.…”

Section: Nuclear Factor (Erythroid-derived 2)-like 2 (Nrf2) and Nementioning

confidence: 99%

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

et al. 2017

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Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning.

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Section: Nuclear Factor (Erythroid-derived 2)-like 2 (Nrf2) and Nementioning

confidence: 99%

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

et al. 2017

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“…Despite the poorly understood etiology of MS, it has been suggested that genetic background and environmental factors may both act as the main drivers of the disease . Several studies have shown that inflammatory factors and oxidative stress play a significant role in the development of demyelination, which occurs through the generation of nitrogen‐ and oxygen‐free radicals as well as the formation of oxidized phospholipids . The oxidative stress caused by these free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species, as toxic reagents to nerve cells, destroys and disrupts their function and plays a key role in the pathological processes of several neurological disorders, such as MS and Alzheimer's disease .…”

Section: Introductionmentioning

confidence: 99%

Effects of crocin in reducing DNA damage, inflammation, and oxidative stress in multiple sclerosis patients: A double‐blind, randomized, and placebo‐controlled trial

Ghiasian

Khamisabadi

Kheiripour

et al. 2019

J Biochem & Molecular Tox

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Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the nerve cells, resulting in neurological disorders. Oxidative stress, free radicals, and neuritis have important roles in MS pathogenesis. Here, we aim to evaluate the effect of crocin on inflammatory markers, oxidative damage, and deoxyribonucleic acid (DNA) damage in the blood of patients with MS. A total of 40 patients were divided into two groups, drug and placebo‐treated groups, using random assignment. Participants of the intervention and control groups received two crocin capsules or placebo per day for 28 days, respectively. Findings revealed a significant decrease in the level of important pathogenic factors in MS, including lipid peroxidation, DNA damage, tumor necrosis factor‐alpha, and interleukin 17 as well as a significant increase in the total antioxidant capacity in the serum of patients treated with crocin compared with the placebo group. Our results suggest the beneficial and therapeutic effects of crocin in MS.

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“…Most of them, but not the n-3 PUFAs, are antioxidants, which make them very useful, as oxidative stress is an important component of the inflammatory processes leading to degradation of myelin and axonal damage. Oxidative stress and inflammation are present in relapsing-remitting and in primary and secondary progressive MS [60,61].…”

Section: Anti-inflammatory Dietary Molecules and Microorganismsmentioning

confidence: 99%

Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis

2018

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Central to the understanding of the relationships between diet, gut microbiota, and vitamins D and A in multiple sclerosis is low-grade inflammation, which is involved in all chronic inflammatory diseases and is influenced by each of the above effectors. We show that food components have either proinflammatory or anti-inflammatory effects and influence both the human metabolism (the "metabolome") and the composition of gut microbiota. Hypercaloric, high-animal-fat Western diets favor anabolism and change gut microbiota composition towards dysbiosis. Subsequent intestinal inflammation leads to leakage of the gut barrier, disruption of the blood-brain barrier, and neuroinflammation. Conversely, a vegetarian diet, rich in fiber, is coherent with gut eubiosis and a healthy condition. Vitamin D levels, mainly insufficient in a persistent low-grade inflammatory status, can be restored to optimal values only by administration of high amounts of cholecalciferol. At its optimal values (>30 ng/ml), vitamin D requires vitamin A for the binding to the vitamin D receptor and exert its anti-inflammatory action. Both vitamins must be supplied to the subjects lacking vitamin D. We conclude that nutrients, including the nondigestible dietary fibers, have a leading role in tackling the low-grade inflammation associated with chronic inflammatory diseases. Their action is mediated by gut microbiota and any microbial change induced by diet modifies host-microbe interactions in a consequent way, to improve the disease or worsen it.

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In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis

Cited by 78 publications

References 36 publications

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Effects of crocin in reducing DNA damage, inflammation, and oxidative stress in multiple sclerosis patients: A double‐blind, randomized, and placebo‐controlled trial

Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis

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