In Vivo Gram Staining of Tinea Versicolor

Spence-Shishido, Allyson; Carr, Christopher; Bonner, Michael Y.; Arbiser, Jack L.

doi:10.1001/jamadermatol.2013.2699

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Recently, our group demonstrated that tinea versicolor retains topical GV and that GV can be applied as a bedside test to determine the presence of fungal colonization as other hypopigmentary disorders do not accentuate with GV. We have named this phenomenon in vivo Gram staining .…”

Section: Antimycotic Activitymentioning

confidence: 99%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

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129

108

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Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an anti-bacterial and anti-fungal, recent reports have shown its utility as an anti-typranosomal, anti-viral and anti-angiogenic agent. The objective of this paper is to summarize evidence regarding the efficacy, and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal, and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.

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Section: Antimycotic Activitymentioning

confidence: 99%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

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129

108

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“…In vivo gram staining is a bedside diagnostic test for tinea versicolor. 33 In this test, when gentian violet is applied to the site of tinea versicolor, a dramatic accentuation of the infected areas compared with unaffected skin occurs due of retention of the dye by the fungus. This test differentiates tinea versicolor from other conditions like atopic dermatitis, vitiligo and pityriasis rosea as these conditions do not retain gentian violet.…”

Section: Other Usesmentioning

confidence: 99%

“…This test differentiates tinea versicolor from other conditions like atopic dermatitis, vitiligo and pityriasis rosea as these conditions do not retain gentian violet. 33 Ink test can be performed for diagnosing porokeratosis. Circumferential furrow of the lesion can be delineated by applying gentian violet to the lesions of porokeratosis.…”

Section: Other Usesmentioning

confidence: 99%

Gentian violet: Revisited

Prabha¹,

Arora²,

Ganguly³

et al. 2020

Indian J Dermatol Venereol Leprol

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“…It is therefore necessary to utilize biofilmdispersing agents periodically in treating TV if we are to successfully prevent chronic disease. The extent of the disease has been shown by in vivo Gram staining (crystal violet) to be very dramatic [18].…”

Section: Sample Collection and Processingmentioning

confidence: 99%

Biofilm Formation by Malassezia Furfur/Ovale as a Possible Mechanism of Pathogenesis in Tinea Versicolor

Hb¹,

Goyal²,

Ogrich³

2015

Clin Exp Dermatol Res

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Malassezia species exist as normal flora on human skin but can convert to a pathogenic state in response to a number of host and environmental factors ultimately resulting in tinea versicolor (TV). Biofilm formation represents one of the main mechanisms by which microorganisms maintain viability in hostile environments. We have shown that Malassezia furfur/ovale cultured from patients with active TV can produce biofilms in vitro and in vivo. Exposure of Malassezia to sweat in vivo is the likely trigger for biofilm formation (as it is in atopic dermatitis); we believe this biofilm formation is potentially responsible for both the pathogenesis and the chronicity of this infection. This gives rationale to biofilm-dispersing agents, such as selenium sulfide, as important components in the standard TV treatment regimen. Periodic use of such agents would conceivably prevent reinfection.

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In Vivo Gram Staining of Tinea Versicolor

Cited by 3 publications

References 3 publications

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Gentian violet: Revisited

Biofilm Formation by Malassezia Furfur/Ovale as a Possible Mechanism of Pathogenesis in Tinea Versicolor

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