In vivo hyperspectral analysis of skin hemoglobin and melanin content for neoplasia detection

Abstract

We present results of main skin chromophores (melanin and hemoglobin) optical analysis. Analysis of 91 in vivo skin tissues (50 benign and 41 malignant) was performed in visible spectral region with hyperspectral imaging technique. To assess the malignancy of skin tissues we proposed two methods for calculating the integral index of tissue optical density and performed a comparison of their effectiveness and effectiveness of physician survey. As the main diagnostic feature, we propose to use data of integral optical index dispersion from the studied tissue and healthy tissue area. The results of skin tissues classification with discriminant analysis are presented. The possibility of the proposed approaches application in the clinical practice is shown.

Hyperspectral Camera – Attachment for Microscopy

“…Previously, studies of hyperspectral imaging were conducted in Refs. [19,20] to determine the types of human skin neoplasms. These studies have shown a fairly high accuracy in determining pathologies.…”

Applications of hyperspectral imaging in the detection and diagnosis of solid tumors

“…Previously, dermoscopy was the fastest device to obtain skin images. Recently, the use of HSI for the diagnosis of skin cancer has shown excellent performances ( 87 , 88 ). Figure 3 shows general steps of HSI body surface inspection.…”