2022
DOI: 10.1038/s41380-022-01580-0
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In vivo imaging of astrocytes in the whole brain with engineered AAVs and diffusion-weighted magnetic resonance imaging

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Cited by 17 publications
(20 citation statements)
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“…( 60 ) found that the ABCB1 C1236T polymorphism was strongly associated with UC. Aquaporin 1 (AQP1) is a water channel protein that is expressed in various tissues, including the brain and lungs ( 61 63 ), where it plays a role in regulating water transport. AQP1 has been shown to be involved in the transport of copper ions into cells, and its expression has been found to be regulated by copper ions ( 64 ).…”
Section: Discussionmentioning
confidence: 99%
“…( 60 ) found that the ABCB1 C1236T polymorphism was strongly associated with UC. Aquaporin 1 (AQP1) is a water channel protein that is expressed in various tissues, including the brain and lungs ( 61 63 ), where it plays a role in regulating water transport. AQP1 has been shown to be involved in the transport of copper ions into cells, and its expression has been found to be regulated by copper ions ( 64 ).…”
Section: Discussionmentioning
confidence: 99%
“…In regard to imaging, for instance, Georgiou et al [106] used axoastrocytic AAV transfer and two-photon microscopy to study the functional-dependent organization of Ca 2+ microdomains and were able to determine stability within occurring patterns. Additionally, in an in vivo study carried out by Li et al [107], a combination of magnetic resonance imaging (MRI) with an AAV vector carrying a reporter was used to uncover dynamic Ca 2+ changes in astrocytes. Furthermore, in our laboratory, we have recently adapted a functional tool to monitor astrocyte activity called CaMPARI GFAP , which is a GECI for astrocytes that undergoes irreversible fluorescence conversion when there is elevated intracellular Ca 2+ and simultaneous delivery of 405 nm light [3].…”
Section: Available Methods For Tracking Astrocytesmentioning
confidence: 99%
“…Chemical probes have also been fabricated for other MRI methods. Xu et al [352] recently reported an engineered adeno-associated virus probe that contains aquaporin reporter gene and fluorescent, and the astrocytes have been detected by both fluorescent imaging and diffusion-weighted MRI. CEST imaging brought more than 3 orders of magnitude detection sensitivity enhancement, and a series of endogenous and exogenous CEST agents has been reported [353][354][355][356].…”
Section: Other Mri Methodsmentioning
confidence: 99%