In vivo imaging of astrocytosis in Alzheimer’s disease: an 11C-L-deuteriodeprenyl and PIB PET study

Neuroinflammation and β Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging

“…The increase in [ 11 C]DED binding was more pronounced in the [ 11 C]PIB-positive MCI subjects. Santillo et al [93] confirmed the increased [ 11 C]DED binding in the frontal, parietal and temporal lobes in AD compared to controls and a significant correlation between binding potential (BP) and PIB retention value. These results suggest that there was an increased number of astrocytes reacting in AD as early as in the predementia state.…”

Imaging of neuroinflammation

“…MAO-B levels can be estimated using L-deprenyl-D2 (DED), a selective irreversible MAO-B antagonist, which has been developed as a PET tracer [25]. Recent PET studies reported significant increase in DED binding in patients with moderate to severe AD compared with healthy control subjects [1]. Similar results were reported in other neurodegenerative disorders such as ALS [26] and Creutzfeldt-Jakob disease [27].…”

“…From basic research to clinical studies, the field has evolved using multidisciplinary techniques and skills, leading to results of significant clinical interest. Reasoning on the role of inflammation in neurodegenerative disease, the recent paper by Santillo et al [1] is an example of the breadth and depth of the evolving impact of molecular imaging on the field of neurodegeneration and stimulates a reflection on the state of the art of target-specific positron emission tomography (PET) probes of inflammation for brain imaging.…”

Appropriate use criteria for amyloid PET imaging cannot replace guidelines: On behalf of the European Association of Nuclear Medicine

“…Subsequently many studies have replicated this finding [3][4][5][6][7]. Also, a substantial number of papers on [ 11 C]PiB PET have been published in the European Journal of Nuclear Medicine and Molecular Imaging, which underscores the recognition of the importance of this topic by the Editorial Board of our Journal [8][9][10][11]. Importantly, several studies confirmed that the in vivo observations with [ 11 C]PiB PET are highly correlated with post-mortem assessment of amyloid pathology [12][13][14] [21,22].…”