In vivo imaging of extracellular pH using1H MRSI

Sluis, Robert van; Bhujwalla, Zaver M.; Raghunand, Natarajan; Ballesteros, Paloma; Alvarez, Julissa; Cerdán, Sebastián; Galons, Jean Philippe; Gillies, Robert J.

doi:10.1002/(sici)1522-2594(199904)41:4<743::aid-mrm13>3.0.co;2-z

Cited by 297 publications

(92 citation statements)

References 17 publications

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“…Acidosis is another characteristic feature of the tumor microenvironment [13,78,79,80,81]. Normal tissue pH in humans is tightly regulated around pH 7.4.…”

Section: Acidosis Is a Hallmark Of The Tumor Microenvironmentmentioning

confidence: 99%

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Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

Justus

Sanderlin

Yang

2015

IJMS

126

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Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemoprevention.

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“…Acidosis is another characteristic feature of the tumor microenvironment [13,78,79,80,81]. Normal tissue pH in humans is tightly regulated around pH 7.4.…”

Section: Acidosis Is a Hallmark Of The Tumor Microenvironmentmentioning

confidence: 99%

“…Normal tissue pH in humans is tightly regulated around pH 7.4. The pH of the tumor microenvironment, however, may range from pH 5.5 to 7.4 [13,78,79,80,81]. The tumor microenvironment is in constant flux.…”

Section: Acidosis Is a Hallmark Of The Tumor Microenvironmentmentioning

confidence: 99%

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

Justus

Sanderlin

Yang

2015

IJMS

126

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“…The low sensitivity of 31 P MRS, however, results in limited spatial resolution. To improve spatial resolution, pH e imaging has been performed in tumors in vivo using probes detected with 1 H MRSI such as (imidazol-1-yl)3-ethyoxycarbonylpropionic acid (van Sluis et al, 1999), or 2-(imidazol-1-yl)succinic acid (Provent et al, 2007). …”

Section: Imaging and Pm/theranostics Of The Physiological Microenvmentioning

confidence: 99%

Molecular Imaging of the Tumor Microenvironment for Precision Medicine and Theranostics

Penet

Krishnamachary

Chen

et al. 2014

Advances in Cancer Research

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Morbidity and mortality from cancer and their associated conditions and treatments continue to extract a heavy social and economic global burden despite the transformative advances in science and technology in the twenty-first century. In fact, cancer incidence and mortality are expected to reach pandemic proportions by 2025, and costs of managing cancer will escalate to trillions of dollars. The inability to establish effective cancer treatments arises from the complexity of conditions that exist within tumors, the plasticity and adaptability of cancer cells coupled with their ability to escape immune surveillance, and the co-opted stromal cells and microenvironment that assist cancer cells in survival. Stromal cells, although destroyed together with cancer cells, have an ever-replenishing source that can assist in resurrecting tumors from any residual cancer cells that may survive treatment. The tumor microenvironment landscape is a continually changing landscape, with spatial and temporal heterogeneities that impact and influence cancer treatment outcome. Importantly, the changing landscape of the tumor microenvironment can be exploited for precision medicine and theranostics. Molecular and functional imaging can play important roles in shaping and selecting treatments to match this landscape. Our purpose in this review is to examine the roles of molecular and functional imaging, within the context of the tumor microenvironment, and the feasibility of their applications for precision medicine and theranostics in humans.

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“…The extracellular pH of normal tissues is kept constant at pH 7.4 and the pH value in the intratumoral space is within the range of 6.8-7.2 [81]. To design efficient tumor-targeting carriers, polymeric micelles which release their payloads in a pH sensitive manner are necessary.…”

Section: Polymeric Micelles With Drug Conjugationmentioning

confidence: 99%

Core/Shell Nanoparticles for Drug Delivery and Diagnosis

Lee¹,

Kim²,

Lee³

et al. 2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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Core/shell nanoparticles (NPs) are formed using various strategies and offer considerable advantages for diagnosis and therapy. Because of the hydrophilic nature of their shell with relatively small size, core/shell NPs have been utilized to solubilize hydrophobic drugs as well as imaging agents, improving pharmacokinetics. This chapter will introduce various types of core/shell NPs based on their preparation method and formation mechanism. The focus will be on the core/shell nanomedicine for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.

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In vivo imaging of extracellular pH using1H MRSI

Cited by 297 publications

References 17 publications

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

Molecular Imaging of the Tumor Microenvironment for Precision Medicine and Theranostics

Core/Shell Nanoparticles for Drug Delivery and Diagnosis

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