In vivo imaging of microenvironmental and anti-PD-L1-mediated dynamics in cancer using S100A8/S100A9 as an imaging biomarker

Helfen, Anne; Riess, Jan; Fehler, Olesja; Stölting, Miriam; An, Zhengwen; Kocman, Vanessa; Schnepel, Annika; Geyer, Christiane; Gerwing, Mirjam; Masthoff, Max; Vogl, Thomas J.; Höltke, Carsten; Roth, Johannes; Ng, Tony; Wildgruber, Moritz; Eisenblätter, Michel

doi:10.1016/j.neo.2022.100792

Cited by 5 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of stabilized tumor cell lines for particular cancer types is restricted, limiting the available models [52]. However, several well-established cell lines are commonly used for breast cancer studies, such as the metastatic cells 4T1 and non-metastatic cells 67NR for BALB/c mice [53][54][55] and EO771 metastatic breast cancer cell line for C57BL/6 mice [56][57][58]. When conducting studies that require large group numbers, the syngeneic system is convenient for rapid and reproducible expansion of tumor cell lines before implantation into hosts [59].…”

Section: Transplantable Modelsmentioning

confidence: 99%

Mouse models for cancer research – current state and the perspective

Gercakova,

Poturnajova,

Tyciakova

et al. 2024

neo

View full text Add to dashboard Cite

Cancer is one of the leading causes of death worldwide. We still do not understand all the details of carcinogenesis, and effective treatment is lacking for many oncological diseases. Animal models provide an irreplaceable tool to observe the growth and spreading of neoplastic cells in an environment of living organisms, to test the efficacy of cancer treatment, side effects, and toxicity, and to study the tumor microenvironment. Mice are the most often used model organisms because of their easy handling, short reproductive period, multiple strains, and complete DNA sequencing. An ideal model should accurately recapitulate each step of tumor development. Recent techniques have established models that enable the study of different aspects of cancer, but choosing a particular model depends on the application of output data. This article aimed to review induced, transplantable, and engineered mice and highlight their significance for recent and future cancer research.

show abstract

Section: Transplantable Modelsmentioning

confidence: 99%

Mouse models for cancer research – current state and the perspective

Gercakova,

Poturnajova,

Tyciakova

et al. 2024

neo

View full text Add to dashboard Cite

show abstract

“…Lately, S100A8 and S100A9 have been increasingly used as in vivo imaging biomarkers in cancer [ 124 ]. Accordingly, the target-specific imaging of S100A8/A9 can be used to visualize the tumor-immune interaction.…”

Section: The Yin and Yang Of Pro- And Anti-inflammatory Macrophages U...mentioning

confidence: 99%

The Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation

Austermann

Roth

Barczyk-Kahlert

2022

Cells

Self Cite

View full text Add to dashboard Cite

Monocytes and macrophages are central players of the innate immune response and play a pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases of the immune response, from initiating inflammation and triggering the adaptive immune response, through to the clearance of cell debris and resolution of inflammation. In this review, we described the mechanisms of monocyte and macrophage adaptation to rapidly changing microenvironmental conditions and discussed different forms of macrophage polarization depending on the environmental cues or pathophysiological condition. Therefore, special focus was placed on the tight regulation of the pro- and anti-inflammatory immune response, and the diverse functions of S100A8/S100A9 proteins and the scavenger receptor CD163 were highlighted, respectively. We paid special attention to the function of pro- and anti-inflammatory macrophages under pathological conditions.

show abstract

“…Moreover, inhibition of S100A8 could improve chemotherapy sensitivity by reducing autophagy in B-cell lymphoma cells with strong drug resistance (25). Simultaneously, S100A8/S100A9 activation facilitates leukocyte recruitment, angiogenesis, and tumor migration, along with the enhancement of some genes, including Cxcl1, Ccl5 and Ccl7, Slc39a10, Lcn2, Zc3h12a, Enpp2 and other genes (26,27). Generally, the role of S100A8 in multiple tumors is highlighted as a promotor of tumor invasion, TME formation, and drug resistance (14,16,28), however, there has been no direct report on relationship between S100A8 and DLBCL.…”

Section: Introductionmentioning

confidence: 99%

S100A8 is a prognostic signature and associated with immune response in diffuse large B-cell lymphoma

Lin,

Su,

Fang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

BackgroundS100A8, a calcium-binding protein belonging to the S100 family, is involved in immune responses and multiple tumor pathogens. Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of B-cell lymphoma and remains incurable in 40% of patients. However, the role of S100A8 and its regulation of the immune response in DLBCL remain unclear.MethodsThe differential expression of S100A8 was identified via the GEO and TCGA databases. The prognostic role of S100A8 in DLBCL was calculated using the Kaplan-Meier curve. The function enrichment of differentially expressed genes (DEGs) was explored through GO, KEGG, GSEA, and PPI analysis. In our cohort, the expression of S100A8 was verified. Meanwhile, the biological function of S100A8 was applied after the inhibition of S100A8 in an in vitro experiment. The association between S100A8 and immune cell infiltration and treatment response in DLBCL was analyzed.ResultsS100A8 was significantly overexpressed and related to a poor prognosis in DLBCL patients. Function enrichment analysis revealed that DEGs were mainly enriched in the IL-17 signaling pathway. Our cohort also verified this point. In vitro experiments suggested that inhibition of S100A8 should promote cell apoptosis and suppress tumor growth. Single-cell RNA sequence analysis indicated that S100A8 might be associated with features of the tumor microenvironment (TME), and immune infiltration analyses discovered that S100A8 expression was involved in TME. In terms of drug screening, we predicted that many drugs were associated with preferable sensitivity.ConclusionElevated S100A8 expression is associated with a poor prognosis and immune infiltration in DLBCL. Inhibition of S100A8 could promote cell apoptosis and suppress tumor growth. Meanwhile, S100A8 has the potential to be a promising immunotherapeutic target for patients with DLBCL.

show abstract

In vivo imaging of microenvironmental and anti-PD-L1-mediated dynamics in cancer using S100A8/S100A9 as an imaging biomarker

Cited by 5 publications

References 35 publications

Mouse models for cancer research – current state and the perspective

Mouse models for cancer research – current state and the perspective

The Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation

S100A8 is a prognostic signature and associated with immune response in diffuse large B-cell lymphoma

Contact Info

Product

Resources

About