In vivo imaging of retinal hemodynamics with OCT angiography and Doppler OCT

Huang, Shenghai; Shen, Meixiao; Zhu, Dexi; Chen, Qi; Shi, Chaoji; Chen, Zhongping; Liu, Fan

doi:10.1364/boe.7.000663

Cited by 26 publications

(19 citation statements)

References 41 publications

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“…In addition, OCT-A enables also functional assessment of blood vessels in the retina and choroid, without the need of an intravenous dye. 6 Recently, OCT-A is widely used in the diagnosis of neovascular AMD. Based on the motion contrast in the different structural layers (superficial and deep vascular plexuses, avascular retina, choriocapillaris), OCT-A allows precise visualization of CNV -dimensions and morphology.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration

2019

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Age-related macular degeneration is a leading cause of irreversible vision loss in individuals over 55 years of age worldwide. Conventionally, it is divided into two subtypes – dry (non-neovascular) and wet (neovascular) form. Neovascular age-related macular degeneration comprises only 10-15% of all patients but is responsible for more than 80% of blindness related to the disease. It requires early diagnosis and timely treatment. Fluorescein angiography is the current ‘gold standard’ for diagnosing neovascular forms. However, as an invasive procedure, it may be contraindicated in some circumstances and cause serious adverse effects. Optical coherence tomography-angiography is a relatively new, non-invasive and fast imaging modality gaining popularity in the diagnosis of age-related macular degeneration, especially for the neovascular form of the disease. It enables structural and functional information of blood vessels in the retina and choroid, without the need of an intravenous dye. In this study we present and discuss 3 cases of different subtypes of choroidal neovascularization secondary to neovascular age-related macular degeneration. All of them were examined by fluorescein angiography and optical coherence tomography-angiography. The results were qualitatively analyzed.

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Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration

2019

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“…[1][2][3] The quality of images is vital for OCT. In reality, since OCT is based on low-coherence interferometry, [4][5][6] it inevitably brings speckle noise to OCT images.…”

Section: Introductionmentioning

confidence: 99%

Improved wavelet hierarchical threshold filter method for optical coherence tomography image de-noising

Cao

Wang

et al. 2018

J. Innov. Opt. Health Sci.

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According to the speckle feature in Optical coherence tomography (OCT), images with speckle indicate not only noise but also signals, an improved wavelet hierarchical threshold¯lter (IWHTF) method is proposed. At¯rst, a modi¯ed hierarchical threshold-selected algorithm is used to prevent signals from being removed by assessing suitable thresholds for di®erent noise levels. Then, an improved wavelet threshold function based on two traditional threshold functions is proposed to trade-o® between speckle removing and sharpness degradation. The de-noising results of an OCT¯nger skin image shows that the IWHTF method obtains better objective evaluation metrics and visual image quality improvement. When ¼ 0:2, ¼ 5:0 and K ¼ 1:2, the improved method can achieve 9.58 dB improvement in signal-to-noise ratio, with sharpness degraded by 3.81%.

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“…With the developments of laser and optics, various optical imaging approaches are becoming the primary tools for intravital imaging over the last decades. The advantages in terms of superior spatiotemporal resolution, multichannel parallel detection, and time‐lapse dynamic monitoring permit us to monitor blood flow dynamics , tracking angiogenesis, tumor growth and interventional treatment , etc. for small living animals.…”

Section: Introductionmentioning

confidence: 99%

FSOCA‐induced switchable footpad skin optical clearing window for blood flow and cell imaging in vivo

Shi¹,

Feng²,

Zhang³

et al. 2017

Journal of Biophotonics

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The mouse footpad for its feature of hairlessness provides an available window for imaging vascular and cellular structure and function in vivo. Unfortunately, the strong scattering of its skin limits the penetration of light and reduces the imaging contrast and depth. Herein, an innovative footpad skin optical clearing agent (FSOCA) was developed to make the footpad skin transparent quickly by topical application. The results demonstrate that FSOCA treatment not only allowed the cutaneous blood vessels and blood flow distribution to be monitored by laser speckle contrast imaging technique with higher contrast, but also permitted the fluorescent cells to be imaged by laser scanning confocal microscopy with higher fluorescence signal intensity and larger imaging depth. In addition, the physiological saline-treatment could make the footpad skin recover to the initial turbid status, and reclearing would not induce any adverse effects on the distributions and morphologies of blood vessels and cells, which demonstrated a safe and switchable window for biomedical imaging. This switchable footpad skin optical clearing window will be significant for studying blood flow dynamics and cellular immune function in vivo in some vascular and immunological diseases.

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In vivo imaging of retinal hemodynamics with OCT angiography and Doppler OCT

Cited by 26 publications

References 41 publications

Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration

Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration

Improved wavelet hierarchical threshold filter method for optical coherence tomography image de-noising

FSOCA‐induced switchable footpad skin optical clearing window for blood flow and cell imaging in vivo

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