In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

Enfield, Joey; Jonathan, Enock; Leahy, Martin J.

doi:10.1364/boe.2.001184

Cited by 226 publications

(247 citation statements)

References 29 publications

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“…The color-coded angiogram can be superimposed on a gray-scale, cross-sectional, structural OCT image to demonstrate blood flow and structural information simultaneously. Flow projection artifacts are a common problem for existing OCT angiography techniques (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). To better distinguish and interpret the blood flow within different layers, a negative filter was used to mask projection artifacts from the larger caliber retinal vessels (24).…”

Section: Discussionmentioning

confidence: 99%

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Jia

Bailey

Hwang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

600

469

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Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.optical coherence tomography angiography | ophthalmic imaging | ocular circulation O ptical coherence tomography (OCT) has become the most commonly used imaging modality in ophthalmology. It provides cross-sectional and 3D imaging of the retina and optic nerve head with micrometer-scale depth resolution. Structural OCT enhances the clinician's ability to detect and monitor fluid exudation associated with retinal vascular diseases. Whereas anatomical alterations that impact vision are readily visible, structural OCT has a limited ability to image the retinal or choroidal vasculatures. Furthermore, it is unable to directly detect capillary dropout or pathologic new vessel growth (neovascularization) that are the major vascular changes associated with two of the leading causes of blindness, age-related macular degeneration (AMD) and diabetic retinopathy (1). To visualize these changes, traditional i.v. contrast dye-based angiography techniques are currently used.Fluorescein dye is primarily used to visualize the retinal vasculature. A separate dye, indocyanine green (ICG), is necessary to evaluate the choroidal vasculature. Both fluorescein angiography (FA) and ICG angiography require i.v. injection, which is time consuming, and which can cause nausea, vomiting, and, rarely, anaphylaxis (2). Dye leakage or staining provides information regarding vascular incompetence (e.g., from abnormal capillary growth), but it also obscures the image and blurs the boundaries of neovascularization. Additionally, conventional angiography is 2D, which makes it difficult to distinguish vascular abnormalities within different layers. Therefore, it is desirable to develop a no-injection, dye-free method...

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Section: Discussionmentioning

confidence: 99%

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Jia

Bailey

Hwang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

600

469

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“…Spectral characteristics of the objects were derived from OCT [19], and the authors of [20] studied molecules. A correlation method for imaging the vascular system has been recently developed at our laboratory [21]. An interference microscope with a synthesised aperture has been proposed to improve the resolution of the image areas outside the focal plane [22,23].…”

Section: Introductionmentioning

confidence: 99%

Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures

Alexandrov¹,

Subhash²,

Leahy³

2014

Quantum Electron.

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Publication InformationS. Alexandrov, H. Subhash, M. Leahy (2014) 'Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures'. Quantum Electronics, 44 (7):657-663. Publisher IOP ScienceLink to publisher's version http://dx.doi.org/10.1070/QE2014v044n07ABEH015487Item record http://hdl.handle.net/10379/4532Quantum Electronics 44 (7) 657 - 663 (2014) © 2014 Kvantovaya Elektronika and Turpion Ltd Abstract. We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach is based on spectral encoding of spatial frequency. Information about the spatial structure is directly translated from the Fourier domain to the image domain as different wavelengths, without compromising the accuracy. Axial spatial period profiles of the structure are reconstructed for any volume of interest within the 3D OCT image with nanoscale sensitivity. An example of application of the nanoscale OCT to probe the internal structure of medico-biological objects, the anterior chamber of an ex vivo rat eye, is demonstrated.

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“…Finally, a threshold mask was applied to the averaged cross-sectional OCTA images to remove regions with low OCT signal where the OCTA data is invalid [21,24,32]. In this study, an empirical threshold of ~mean (background noise) + 1.6 x standard deviation (background noise) was used.…”

Section: Endoscopic Oct Angiography and Data Visualizationmentioning

confidence: 99%

“…OCTA was later performed using motion contrast, by calculating the amplitude, phase, or complex amplitude variation of the OCT signals between neighboring B-scan frames [27]. Amplitude-based OCTA relaxes system phase stability requirements and has good sensitivity to slow blood flows in the capillaries [28][29][30][31][32]. In addition, the majority of microvasculature is oriented transverse to the OCT beam, and thus it is difficult to visualize with Doppler OCT because of the small axial phase shift from the Doppler effect.…”

Section: Introductionmentioning

confidence: 99%

Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

Lee

Ahsen

Liang

et al. 2016

Biomed. Opt. Express

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Abstract:We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm 2 area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA imaging of the swine esophagus in vivo is demonstrated.

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In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

Cited by 226 publications

References 29 publications

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures

Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

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