In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease

Baron, Jean‐Claude; Chételat, Gaël; Desgranges, Béatrice; Perchey, Guy; Landeau, Brigitte; Sayette, Vincent de La; Eustache, Francis

doi:10.1006/nimg.2001.0848

Cited by 632 publications

(418 citation statements)

References 39 publications

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“…[33][34][35][36] As expected, these differences are less profound between MCI and AD and between MCI and normal aging. Thus, in agreement with clinical observations that place MCI between normal cognitive aging and AD based on atrophy severity, MCI likewise appears to be intermediate between normal aging and AD.…”

Section: Figsupporting

confidence: 74%

Brain Mapping as a Tool to Study Neurodegeneration

Apostolova

Thompson

2007

Neurotherapeutics

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Summary: Alzheimer's disease (AD) is the most common neurodegenerative disorder for those 65 years or older; it currently affects 4.5 million in the United States and is predicted to rise to 13.2 million by the year 2050. Neuroimaging and brain mapping techniques offer extraordinary power to understand AD, providing spatially detailed information on the extent and trajectory of the disease as it spreads in the living brain. Computational anatomy techniques, applied to large databases of brain MRI scans, reveal the dynamic sequence of cortical and hippocampal changes with disease progression and how these relate to cognitive decline and future clinical outcomes. People who are mildly cognitively impaired, in particular, are at a fivefold increased risk of imminent conversion to dementia, and they show specific structural brain changes that are predictive of imminent disease onset. We review the principles and key findings of several new methods for assessing brain degeneration, including voxel-based morphometry, tensor-based morphometry, cortical thickness mapping, hippocampal atrophy mapping, and automated methods for mapping ventricular anatomy. Applications to AD and other dementias are discussed, with a brief review of related findings in other neurological and neuropsychiatric illnesses, including epilepsy, HIV/AIDS, schizophrenia, and disorders of brain development.

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Section: Figsupporting

confidence: 74%

Brain Mapping as a Tool to Study Neurodegeneration

Apostolova

Thompson

2007

Neurotherapeutics

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“…In contrast to the right-sided temporal pattern in PCA the typical AD patients showed a more left-sided temporal predominance which has been reported before [3,26]. In fact the typical AD subjects had significantly greater atrophy of the left medial temporal lobe (particularly the hippocampus) and inferior and middle temporal gyri than the PCA patients, reflecting the deficits in episodic memory that are found in patients with typical AD.…”

Section: Discussionmentioning

confidence: 45%

“…Frontal lobe atrophy is a common finding on MRI in typical AD [3,18,30], and case reports have similarly shown evidence that the frontal lobes can become affected over time in PCA, both clinically, with deficits in executive function and typical signs such as echopraxia and perseverations, and on FDG-PET and SPECT [21,41,46]. In fact the location of the frontal lobe atrophy in PCA coincides with regions of hypometabolism identified in the frontal eye fields in a recent FDG-PET study [41] where the authors hypothesized that damage to these regions may result from degeneration of the afferent input from the occipito-parietal cortices, and may contribute to ocular apraxia in PCA [41].…”

Section: Discussionmentioning

confidence: 99%

“…This technique uses unbiased statistics to assess patterns of cerebral atrophy throughout the whole brain in groups of subjects. A number of VBM studies have demonstrated atrophy of the hippocampus and medial temporal lobe regions, the posterior cingulate gyrus, precuneus, temporoparietal neocortex and prefrontal cortex in typical AD [3,10,30,44,52]. Proton MR spectroscopy ( 1 H MRS) is a technique that provides information regarding the neurochemistry of the brain, and has been useful in differentiating the common degenerative dementias [14,29].…”

Section: Introductionmentioning

confidence: 99%

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Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

185

143

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The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in subjects with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 subjects with PCA, 38 subjects with typical AD, and 38 controls. Clinical data was assessed in all PCA subjects. Single-voxel 1 H MRS located in the posterior cingulate was analyzed in a subset of subjects with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Subjects with PCA showed greater atrophy in the right visual association cortex than subjects with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1 H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

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“…The relative overlap between morphological and functional abnormalities in SD contrasts with the discordance observed in Alzheimer"s disease [3] and patients at a pre-dementia stage of Alzheimer's [8].…”

Section: Discussionmentioning

confidence: 59%

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

140

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Rare studies have used MRI and voxel based morphometry (VBM) to assess atrophy, and only two PET studies used SPM to examine functional changes in semantic dementia (SD). Our aim was to highlight both morphological and functional abnormalities in a same group of 10 SD patients, in the entire brain, using a "state of the art" methodology (optimized VBM procedure, PET data corrected for partial volume effects and voxel based analyses). We also used an extensive neuropsychological battery. We showed that main alterations concerned the left temporal lobe, in accordance with the striking impairment of semantic memory in SD patients, as well as the hippocampal region, which may partly explain their moderate episodic memory deficits. Hypometabolism was more extensive than grey matter loss in both temporal lobes, and specifically concerned the orbitofrontal areas, consistent with the moderate impairment of executive functions and behavioural changes. While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrast with the discordance observed in Alzheimer"s disease and might be a typical feature of SD.3

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In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease

Cited by 632 publications

References 39 publications

Brain Mapping as a Tool to Study Neurodegeneration

Brain Mapping as a Tool to Study Neurodegeneration

Imaging correlates of posterior cortical atrophy

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

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