In-vivo Microdialysis Study of Extracellular Glutamate Response to Temperature Variance in Subarachnoid Hemorrhage

Effects of Hypothermia on Excitatory Amino Acids and Metabolism in Stroke Patients

“…Mild hypothermia is assumed to exhibit a neuroprotective effect on the ischemic brain by attenuation of the release of excitatory amino acids. [5][6][7]23 However, these studies have been performed with hypothermia starting before the ischemic event. Boris-Moller and Wieloch 24 even questioned the hypothesis that neuroprotection is achieved by abolishing glutamate increase.…”

Cerebral microdialysis as a monitoring method in subarachnoid hemorrhage patients, and correlation with clinical events

“…Some of these characteristics are independent outcome variables. In two of the 12 studies age and gender of the patients was not described [3,18].…”

“…In four studies there was either no description of the CT findings at admission or an insufficient description [3,13,18,20].…”

“…The location of the probe was not clearly described in one study [17]. It was placed in the left or right frontal area in five studies [3,7,12,18,20]. In six studies the microdialysis catheter was implanted during aneurysm surgery and dependent on the location of the aneurysm [4, 9,13,14,16,21].…”

“…A form of clinical rating scale (WFNS, H&H, RLS) was used for these patients at admission in all but one study [18].…”