In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO<sub>4</sub>·H<sub>2</sub>O Nanobundles for Tracing Bone Implant and Bone Regeneration

Huang, Jing; Lv, Zhongwen; Wang, Yu; Wang, Zongliang; Gao, Tianlin; Zhang, Ning; Guo, Min; Zou, Haifeng; Zhang, Peibiao

doi:10.1002/adhm.201600249

Cited by 23 publications

(20 citation statements)

References 48 publications

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“…To add molecular functionality to nanoparticles and to render them highly stable in biological conditions, the crucial step is to develop a robust synthetic approach for surface modification leading to high‐density coverage with hydrophilic and biocompatible molecules. To meet this requirement, many functionalization methods have been developed, including surface coating with silica, nanosized gold, polymers, biomolecules, proteins, or stabilized DNA ( Figure ) . These multimodal in vivo contrast agents can be detected simultaneously via optical imaging, magnetic resonance imaging (MRI), X‐ray computed tomography (CT), etc .…”

Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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146

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“…They exhibit high chemical stability and excellent thermal stability. [12] Meanwhile, these Gd-based compounds have different elements and groups, and some of them have exhibited biological functions in inducing osteogenic differentiation and the expression of extracellular matrix (ECM). [13] Thus, it is necessary to undertake a comparative study on their physical or chemical properties and potential ostegenic/chondrogenic bioativity when they were employed as contrast agents for PLGA implants.…”

Section: Resultsmentioning

confidence: 99%

“…Among the other gadolinum compounds, gadolinium oxide and gadolinium oxysulfide are the other two good matrix for luminescent materials. They exhibit high chemical stability and excellent thermal stability [12] . Meanwhile, these Gd‐based compounds have different elements and groups, and some of them have exhibited biological functions in inducing osteogenic differentiation and the expression of extracellular matrix (ECM) [13] .…”

Section: Resultsmentioning

confidence: 99%

Incorporation of Gadolinium Oxide and Gadolinium Oxysulfide Microspheres: MRI/CT Monitoring and Promotion of Osteogenic/Chondrogenic Differentiation for Bone Implants

Huang

Tang²,

Guo

et al. 2020

ChemNanoMat

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The current biodegradable polymer materials, as orthopedic implants, can not be traced timely by using the existing medical imaging techniques due to low density and lack of relaxed hydrogen proton ability. Considering the paramagnetism of gadolinium and the particularity of micro/ nano materials, we synthesized inorganic gadolinium oxide and gadolinium oxysulfide microspheres with regular morphology and uniform size without doped rare earth. After incorporation into biodegradable polymer of poly(lactic-coglycolic acid), their effects on signals of MRI, CT and osteogenic/chondrogenic differentiation were investigated to acquisition of multifunctional micro/nano composites for bone implants. At the studied concentrations, gadolinium oxide microspheres showed higher signal than gadolinium oxysulfide microspheres on T 1-weighted imaging. Both of them were of fine biocompatibility and did not show their negative effect on adhesion and proliferation in the concentration of 0.4% (w/w, Gd/PLGA). Meanwhile, the osteogenic/ chondrogenic differentiation of MC3T3-E1 preosteoblasts, including ALP activity, calcium deposition and expression of Runx2, OPN, OCN, COL I and COL II in mRNA and protain, were stimulated at different level, which indicated that moderate use the inorganic gadolinium oxide and gadolinium oxysulfide microspheres could realize the function of tracing the polymer bone implants by MRI/CT and inducing the osteogenic/chondrogenic differentiation simultaneously.

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“…169 Solvothermal synthesized GdPO 4 H 2 O nanobundles incorporated HA and PLGA serve as a biodegradable and traceable bone implant for MRI and X-ray tracing; this unique biomaterial promotes OCN expression in MC3T3-E1 cells and bone mineralization in vivo rabbit radius defects (Figure 3I). 171 GdPO 4 /chitosan scaffolds prepared by the lyophilization method improve the osteoconductivity, resulting in admired cell spreading and in vivo bone tissue in-growth. GdPO 4 nanoparticles in the GdPO 4 /CTS scaffolds robustly promote osteogenic differentiation by upregulating the levels of ALP, RUNX2, OCN, and COLI expression in rabbit BMSCs via activation of the Smad/ RUNX2 signaling pathway (Figure 3VI).…”

Section: Gadoliniummentioning

confidence: 99%

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Duraipandy

Wang

et al. 2021

Bioengineering & Transla Med

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Bone grafts or prosthetic implant designing for clinical application is challenging due to the complexity of integrated physiological processes. The revolutionary advances of nanotechnology in the biomaterial field expedite and endorse the current unresolved complexity in functional bone graft and implant design. Rare earth (RE) materials are emerging biomaterials in tissue engineering due to their unique biocompatibility, fluorescence upconversion, antimicrobial, antioxidants, and anti‐inflammatory properties. Researchers have developed various RE smart nano‐biomaterials for bone tissue engineering and implantology applications in the past two decades. Furthermore, researchers have explored the molecular mechanisms of RE material‐mediated tissue regeneration. Recent advances in biomedical applications of micro or nano‐scale RE materials have provided a foundation for developing novel, cost‐effective bone tissue engineering strategies. This review attempted to provide an overview of RE nanomaterials' technological innovations in bone tissue engineering and implantology and summarized the osteogenic, angiogenic, immunomodulatory, antioxidant, in vivo bone tissue imaging, and antimicrobial properties of various RE nanomaterials, as well as the molecular mechanisms involved in these biological events. Further, we extend to discuss the challenges and prospects of RE smart nano‐biomaterials in the field of bone tissue engineering and implantology.

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In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO₄·H₂O Nanobundles for Tracing Bone Implant and Bone Regeneration

Cited by 23 publications

References 48 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Incorporation of Gadolinium Oxide and Gadolinium Oxysulfide Microspheres: MRI/CT Monitoring and Promotion of Osteogenic/Chondrogenic Differentiation for Bone Implants

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

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In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4·H2O Nanobundles for Tracing Bone Implant and Bone Regeneration

Cited by 23 publications

References 48 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Incorporation of Gadolinium Oxide and Gadolinium Oxysulfide Microspheres: MRI/CT Monitoring and Promotion of Osteogenic/Chondrogenic Differentiation for Bone Implants

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

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Product

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In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO₄·H₂O Nanobundles for Tracing Bone Implant and Bone Regeneration