In vivo mucoadhesive strength appraisal of gum Manilkara zapota

Singh, Sudarshan; B, Bothara Sunil

doi:10.1590/s1984-82502015000300021

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Room temperature was maintained between 22±2°C and relative humidity 50-65%. They were provided with food and water ad libitum [9]. All the animals were acclimatized to the laboratory for 14 days before the start of the study.…”

Section: Determination Of Pharmacokinetic Data (In Vivo Method)mentioning

confidence: 99%

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Design and Comparative Evaluation of Clarithromycin Gastric Bioadhesive Tablets by Ex Vivo and in Vivo Methods

Balasubramanian

Rajasekaran

2018

Asian J Pharm Clin Res

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Objective: The present investigation was to formulate controlled release of mucoadhesive clarithromycin tablets using natural polymers.Methods: Tamarind seed polysaccharide obtained from Tamarindus indica and chitosan act as natural polymers. The formulated tablets of the combined form of thrombospondin (TSP) and chitosan were analyzed by in vitro dissolution method. The optimized formulations were selected for ex vivo and in vivo studies and compared with hydroxypropyl methylcellulose K100 polymer by evaluating gastric retention period by X-ray imaging technique, and drug bioavailability by a pharmacokinetic method from blood samples was determined by high-performance liquid chromatography-mass spectrometry method.Results: The gastric mucoadhesive tablets were prepared using chito-TSP polymers. The in vitro drug release showed good release character for 24 h. The ex vivo studies of tablets showed good adhesive property for a long time. The X-ray imaging technique also proved the adhesive character of tablets. From blood serum sample of rabbits, bioavailability of the drug is in according to the controlled release mechanism.Conclusion: The selected formulations were subjected to stability studies. The study concluded that combination of chitosan and TSP is best natural polymer for mucoadhesion by the advantages of controlled release and biodegradation.

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Section: Determination Of Pharmacokinetic Data (In Vivo Method)mentioning

confidence: 99%

“…Healthy adult Male New Zealand white strain rabbits weighing 1.5- agents and were exposed to X-ray to ascertain the location and nature of tablet in the stomach [9].…”

Section: Determination Of Gastric Retention Time By X-ray Imaging Tecmentioning

confidence: 99%

Design and Comparative Evaluation of Clarithromycin Gastric Bioadhesive Tablets by Ex Vivo and in Vivo Methods

Balasubramanian

Rajasekaran

2018

Asian J Pharm Clin Res

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“…The values were recorded in triplicate ( n = 3), and the mean was calculated. An almost similar apparatus and method has already been used for measuring mucoadhesive strength in literature [17,18,19]. …”

Section: Methodsmentioning

confidence: 99%

An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It

et al. 2017

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The aim of this study is to evaluate the adhesion ability of okra gum, which is gaining popularity as a tablet binder. For this purpose, gum was extracted from okra pods, and the binding strength of different concentrations (1%, 3%, and 5%) was determined quantitatively. Additionally, naproxen sodium tablets were prepared by using okra gum as a binder and were evaluated for their properties including hardness, friability, disintegration time, and dissolution rate. The binding strength values were compared with that of pre-gelatinized starch, a commonly used tablet binder. The results from universal testing machine indicate that the binding strengths of all dispersions of okra increase as the concentration increases from 1% to 5% and ranges from 2.5 to 4.5 N, which are almost twice a high as those of pre-gelatinized starch. The tablets prepared with okra gum have shown good mechanical strength with hardness values of 7–8.5 kg/cm2 and a friability <1%, comparable to tablets prepared with starch. The disintegration time was longer (7.50 min with okra gum and 5.05 min with starch paste), and the drug release from these tablets was slower than the formulations with starch. The higher binding ability of okra gum probably linked with its chemical composition as it mainly contains galactose, rhamnose, and galacturonic acid. This study concludes that okra gum is a better binder than pre-gelatinized starch, it might be explored in future for introduction as a cost-effective binder in the pharmaceutical industry.

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Characterization of a novel, co-processed bio-based polymer, and its effect on mucoadhesive strength

Singh

Nwabor

Ontong

et al. 2020

International Journal of Biological Macromolecules

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In vivo mucoadhesive strength appraisal of gum Manilkara zapota

Cited by 8 publications

References 10 publications

Design and Comparative Evaluation of Clarithromycin Gastric Bioadhesive Tablets by Ex Vivo and in Vivo Methods

Design and Comparative Evaluation of Clarithromycin Gastric Bioadhesive Tablets by Ex Vivo and in Vivo Methods

An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It

Characterization of a novel, co-processed bio-based polymer, and its effect on mucoadhesive strength

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