In vivo  near infrared fluorescence imaging and dynamic quantification of pancreatic metastatic tumors using folic acid conjugated biodegradable mesoporous silica nanoparticles

Li, Hanrui; Li, Ké; Dai, Yunpeng; Xu, Xinyi; Cao, Xu; Zeng, Qi; He, Huyulong; Pang, Liaojun; Liang, Jimin; Chen, Xueli; Zhan, Yonghua

doi:10.1016/j.nano.2018.04.018

Cited by 33 publications

(31 citation statements)

References 36 publications

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“…The hydrodynamic size of the Mn 3 O 4 @PEG-RGD NPs also increased nearly quintuple. This phenomenon was due to the expansion of the PEG hydration layer in the DLS measurements (44,45). Colloidal stability is a critical performance indicator of the NPs (46).…”

Section: Discussionmentioning

confidence: 99%

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Wang

et al. 2020

Front. Oncol.

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Postoperative recurrence is a common and severe problem in the treatment of gastric cancer; consequently, a prolonged course of chemotherapy treatment is inevitable. Monitoring by imaging could provide an accurate evaluation of the therapeutic effects, which would be beneficial to guide a treatment strategy adjustment over time. However, current imaging technologies remain insufficient for the continuous postoperative monitoring of gastric cancer. In this case, molecular imaging offers an efficient strategy. Targetable contrast agents are an essential part of molecular imaging, which could greatly enhance the accuracy and quality of monitoring. Herein, we synthesized a Mn-based contrast agent for magnetic resonance imaging (MRI) of gastric cancer monitoring. Initially, small-sized Mn 3 O 4 nanoparticles (NPs) were synthesized. Then, a functionalized polyethylene glycol (PEG) lipid was attached to the surface of the Mn 3 O 4 NPs, to improve biocompatibility. The targetable MRI contrast agent (Mn 3 O 4 @PEG-RGD NPs) was further prepared by the conjugation of the arginine-glycine-aspartic acid (RGD) peptides. The completed Mn 3 O 4 @PEG-RGD NPs had the small size of 7.3 ± 2.7 nm and exhibited superior colloidal stability in different solution environments. In addition, Mn 3 O 4 @PEG-RGD NPs exhibited reliable biotolerance and low toxicity both in vitro and in vivo. Imaging experiments amply demonstrated that Mn 3 O 4 @PEG-RGD NPs could efficiently accumulate in gastric cancer tissues and cells via RGD mediation, and immediately significantly increased the MRI effects. Through this study, we can conclude that Mn 3 O 4 @PEG-RGD NPs have the potential to be a novel MRI contrast agent for the postoperative monitoring of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Wang

et al. 2020

Front. Oncol.

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“…24,34,35 In this study, hydrophobic Mn 3 O 4 nanoplates were coated with maleimide- The DLS measurement results were slightly higher than the TEM measurements due to hydration and surface coating. 36,37 NPs performance and safety are related to their stability; thus, it is of signicant importance to study the stability of NPs in a strong ionic and simulated body uid environments. To evaluate NPs colloidal stability, the hydrodynamic size of Mn 3 -O 4 @PEG NPs in 10% FBS and 0.01 M PBS solutions and at different temperatures, was measured.…”

Section: Discussionmentioning

confidence: 99%

GMBP1-conjugated manganese oxide nanoplates for in vivo monitoring of gastric cancer MDR using magnetic resonance imaging

Zhan

Cai

et al. 2020

RSC Adv.

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“…46 Moreover, this dye is a wellestablished imaging agent to visualize tumor on mice model. [60][61][62] Mice were imaged before starting the treatment at day 0 (PreT), 5 h and 24 h after injection at day 0 (1T), 4 (2T), 7 (3T), 11 (4T) and 14 (5T) and at the end of the study (EoS). Representative images from N0-and N15-treated mice over time are gathered in Figure 6a.…”

Section: In Vivo and Ex Vivo Fluorescence Imagingmentioning

confidence: 99%

Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for in Vivo Imaging and Cancer Cell Targeting

et al. 2019

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Drug-initiated" nitroxide-mediated synthesis of two well-defined, heterotelechelic polymer prodrugs (M n = 1960-5260 g.mol-1 , Đ = 1.31-1.37) was performed by using the newly-developed nitroxide exchange reaction. These polymers comprised at the chain-end, gemcitabine (Gem) as anticancer drug and either cyanine 7.5 (Cy7.5) as a near-infrared (NIR) dye suitable for in vivo imaging, or biotin (Biot) for cancer cell targeting. These materials were co-nanoprecipitated into fluorescently-labeled polymer prodrug nanoparticles of average diameter in the 100-180 nm with narrow particle size distribution and variable surface amounts of biotin. Nanoparticles containing 15 wt.% biotinylated polymer showed superior uptake and the highest cytotoxicity in vitro on A549 human lung cancer cells. In vivo, on A549 tumor bearing mice, biotinylated nanoparticles showed significantly higher efficacy than free Gem and maintained the same anticancer activity than nontargeted nanoparticles without inducing prohibitive body weight loss. Biotinylated polymer prodrug nanoparticles did not result in an improved anticancer activity or significant increase in tumor accumulation, which may be the result of either a not optimal biotin surface display and/or insufficient affinity towards the target. They however displayed delayed liver accumulation compared to non-biotinylated counterparts, suggesting premise of stealth property likely due to the hydrophilic tetraethyleneglycol-Biot positioned at the nanoparticle surface. This work showed for the first time the applicability of this simple construction method to in vivo imaging and cancer cell targeting, and might stimulate the design of new functional materials for biomedical applications.

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In vivo near infrared fluorescence imaging and dynamic quantification of pancreatic metastatic tumors using folic acid conjugated biodegradable mesoporous silica nanoparticles

Cited by 33 publications

References 36 publications

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

GMBP1-conjugated manganese oxide nanoplates for in vivo monitoring of gastric cancer MDR using magnetic resonance imaging

Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for in Vivo Imaging and Cancer Cell Targeting

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