In vivo neuroprotective, antinociceptive, anti-inflammatory potential in Swiss albino mice and in vitro antioxidant and clot lysis activities of fractionated <i>Holigarna longifolia</i> Roxb. bark extract

Uddin, Zia; Rana, Md. Sohel; Hossain, Shahadat; Ferdous, Sumaiya; Dutta, Emon; Dutta, Mycal; Emran, Talha Bin

doi:10.1515/jcim-2019-0102

Cited by 41 publications

(36 citation statements)

References 33 publications

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“…and biological membranes, causing lipid peroxidation. Consequently, antioxidant efficacy is often cited as a marker of hepatoprotection(Emran et al, 2015;Singhal & Gupta, 2012;Uddin et al, 2019).SGPT, SGOT, and ALP are serum hepatobiliary enzymes present at higher concentrations in the liver. This whole cascade reaction ultimately causes loss of cellular integrity and liver damage(Dolai et al, 2012;Jain et al, 2011;Kiran, Raju, & Rao, 2012;Nirmala, Girija, Lakshman, & Divya, 2012;Ravikumar & Gnanadesigan, 2011;Sengupta, Sharma, & Chakraborty, 2011;Shim et al, 2010;Thabit, Al-Moyed, Al-Balushi, Hasson, & Sallam, 2012;Thirumalai, David, Therasa, & Elumalai, 2011;Zeashan et al, 2008).…”

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confidence: 99%

“…Lipid peroxidation is also a functional parameter of oxidative stress as well as other free radical damage that happens during the biological cascade. Consequently, antioxidant efficacy is often cited as a marker of hepatoprotection(Emran et al, 2015;Singhal & Gupta, 2012;Uddin et al, 2019).SGPT, SGOT, and ALP are serum hepatobiliary enzymes present at higher concentrations in the liver. The trichloromethyl peroxyl radical (CCl 3 O 2 • ) directly interacts with polyunsaturated fatty acids present in the endoplasmic reticulum (ER), causing the elevated production of biomarker enzymes such as SGPT, SGOT, ALP, and bilirubin(Hanafy, Aldawsari, Badr, Ibrahim, & Abdel-Hady, 2016).…”

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Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

Rakib

Ahmed

et al. 2019

Food Science & Nutrition

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This research describes an investigation of the antipyretic and hepatoprotectiveproperties of both a crude organic extract and various subfractions of the ethnomedicinal plant Tinospora crispa, using appropriate animal models. In an attempt to identify potential lead hepatoprotective compounds, in silico experiments were utilized.Antipyretic activity was assessed via the Brewer's yeast-induced pyrexia method, while hepatoprotective effects were evaluated in a carbon tetrachloride (CCl 4 )induced animal model. A computer-aided prediction of activity spectra for substances (PASS) model was applied to a selection of documented phytoconstituents, with the aim of identifying those compounds with most promising hepatoprotective effects.Results were analyzed using Molinspiration software. Our results showed that both the methanol extract (METC) and various subfractions (pet ether, PEFTC; n-hexane, NHFTC; and chloroform, CFTC) significantly (p < .05) reduced pyrexia in a dose-dependent manner. In CCl 4 -induced hepatotoxicity studies, METC ameliorated elevated hepatic markers including serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), and total bilirubin. Malondialdehyde (MDA) levels were significantly reduced, while superoxide dismutase (SOD) levels were significantly increased. Among a selection of metabolites of T. crispa, genkwanin was found to be the most potent hepatoprotective constituent using PASS predictive models. These results demonstrate that both the methanolic extract of T. crispa and those fractions containing genkwanin may offer promise in reducing pyrexia and as a source of potential hepatoprotective agents. K E Y W O R D S antipyretic, CCl 4 -induced hepatotoxicity, hepatoprotective, in silico studies, PASS prediction, Tinospora crispa, yeast-induced pyrexia How to cite this article: Rakib A, Ahmed S, Islam MA, et al. Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches. Food Sci Nutr. 2020;8:547-556. https ://doi.

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Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

Rakib

Ahmed

et al. 2019

Food Science & Nutrition

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“…The antipyretic effect of steroids and flavonoids have been proved in various studies [[36], [37], [38], [39]]. Various researches have also revealed the fact that medicinal plants that show antinociceptive property have also found with antipyretic as well as anti-inflammatory activities [[40], [41], [42], [43], [44], [45], [46], [47]]. It may be due to the mechanism for suppression of pain, fever, and inflammation can be correlated as inhibition of inflammatory mediators is occurred in each case.…”

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confidence: 99%

Pharmacological evidence for the use of Cissus assamica as a medicinal plant in the management of pain and pyrexia

Dutta

Paul²,

Majumder

et al. 2020

Biochemistry and Biophysics Reports

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The existing therapeutic agents for the management of pain and pyrexia are not very efficient and accompanied by numerous side effects. Thus, new effective agents are the most needed. The present study investigates bioactivities and phytochemical screening of different parts of Cissus assamica (Vitaceae), a Bangladeshi tribal medicinal plant. Three plant parts stems, leaves and roots were collected, washed, dried, powdered and then prepared for cold extraction. The methanolic stems and leaves extracts were fractioned with four and two solvents respectively. Different plant extracts were then investigated for in vivo antinociceptive activity and only methanolic leaves extract was investigated for in vivo antipyretic activity. In Swiss-albino mice, 200 and 400 mg/kg body weight doses were used for all extracts. In the peripheral antinociceptive activity, the methanolic stem extract and its dichloromethane, chloroform, pet ether fractions and methanolic roots extract at their both doses showed significant antinociceptive responses when compared to standard diclofenac sodium (60.49% inhibition). In the central antinociceptive activity, the response was found significant for methanolic stem and methanolic roots extract in their both doses compared to standard morphine. In antipyretic activity, methanolic leaves extract significantly reduced pyrexia level at 400 and 200 mg/kg body weight doses after two, three and 4 h of administration when compared to standard. So our findings indicate that this plant possesses noteworthy pharmacological activities which may be a basis for further researches to establish a possible mode of action of its different parts.

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“…The mechanisms of neuropsychiatric disorders are usually the result of either an imbalance of neurotransmitters such as serotonin, GABA, and dopamine or abnormal transmission of serotonergic, glutamatergic, noradrenergic, and GABA-ergic [2,41]. Bioactive compounds are obtained from medicinal plants that should be regulated and inhibit the abnormal release of neurotransmitters [42]. Additionally, in the secondary metabolites of C. velutina leaves, we tested a few qualitative phytochemical screenings where we found some chemical compounds such as resin, phenol, tannin, alkaloid, carbohydrate, and glycosides which played a great role as a psychiatric drug [22,25].…”

Section: Discussionmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

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Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

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In vivo neuroprotective, antinociceptive, anti-inflammatory potential in Swiss albino mice and in vitro antioxidant and clot lysis activities of fractionated Holigarna longifolia Roxb. bark extract

Cited by 41 publications

References 33 publications

Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

Pharmacological evidence for the use of Cissus assamica as a medicinal plant in the management of pain and pyrexia

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

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