In Vivo Prophylactic Activity of QR-435 Against H3N2 Influenza Virus Infection

Oxford, John; Lambkin, Robert; Guralnik, Mario; Rosenbloom, Richard A; Petteruti, Michael P; DiGian, Kelly; LeFante, Carolyn

doi:10.1097/mjt.0b013e3180a7206e

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…Masks impregnated with QR-435 (a flavonoid component) were highly effective in blocking the passage of live H3N2 virus [23]. In vivo prophylactic activity of QR-435 was demonstrated against H3N2 influenza virus infection [24].…”

Section: Resultsmentioning

confidence: 99%

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Maiti¹,

Banerjee²

2020

Preprint

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SARS CoV-2 or COVID-19 pandemic global-outbreak created the most unstable situation of human health-economy. Last two decades different parts of the word experienced smaller or bigger outbreak related to human-coronaviruses. The spikeglycoproteins of the COVID-19 (similar to SARS-CoV) attach to the angiotensin-converting-enzyme (ACE-2) and transit over a stabilized open-state for the viral-internalization to the host-cells and propagate with great efficacy. Higher rate of mutability makes this virus unpredictable/less-sensitive to the protein/nucleic-acid based-drugs. In this emergent situation, drug-induced destabilization of spike-binding to RBD could be a good strategy. In the current study we demonstrated by Bioinformatics (CASTp: Computed-Atlas-of-Surface-Topography, PyMol: molecular-visualization) and Molecular docking (PatchDock) experiments that tea flavonoids catechin-products mainly EGCG or other like theaflavin gallate demonstrated higher Atomic Contact Energy (ACE), surface area and more amino-acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike-protein. Moreover, out of three distinct binding-sites (I, II and III) of spike core when HCQ binds only with site III (farthest from the nCoV-RBD of ACE2 contact), EGCG and TG bind all three sites. As because site I and II is in closer contact with open state location and viral-host contact area so these drugs might have significant effects. Taking into account the toxicity/side-effects by CQ/HCQ, present drugs may be important. Our laboratory is working on tea flavonoids and other phytochemicals in the protection from toxicity, DNA/mitochondrial damage, inflammation etc. The present data might be helpful for further analysis of flavonoids in this emergent pandemic situation.

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Section: Resultsmentioning

confidence: 99%

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Maiti¹,

Banerjee²

2020

Preprint

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“…As a result of the studies described above, a number of studies have been done to show the adequacy of ferrets as models for testing vaccine efficacy (reviewed by van der Laan et al, 2008; {Huber, 2008 #4356;Parks, 2007 #4357} and the effectiveness of antiviral drug therapy (Smee et al, 2008; Oxford et al, 2007; Malakhov et al, 2006). …”

Section: Seasonal Influenzamentioning

confidence: 99%

Animal models for the study of influenza pathogenesis and therapy

2009

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Influenza A viruses causes a variety of illnesses in humans. The most common infection, seasonal influenza, is usually a mild, self-limited febrile syndrome, but it can be more severe in infants, the elderly, and immunodeficient persons, in whom it can progress to severe viral pneumonitis or be complicated by bacterial superinfection, leading to pneumonia and sepsis. Seasonal influenza also occasionally results in neurologic complications. Rarely, viruses that have spread from wild birds to domestic poultry can infect humans; such "avian influenza" can range in severity from mild conjunctivitis through the rapidly lethal disease seen in persons infected with the H5N1 virus that first emerged in Hong Kong in 1997. To develop effective therapies for this wide range of diseases, it is essential to have laboratory animal models that replicate the major features of illness in humans. This review describes models currently in use for elucidating influenza pathogenesis and evaluating new therapeutic agents.

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“…Most notably some of these preparations were not only effective in the ferret model (Oxford et al , 2007a ) but also have already demonstrated clinical effi cacy during the SARS epidemic in 2003 (Lau et al , 2005 ).…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections

Ludwig

2011

Biological Chemistry

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Infl uenza is still one of the major plagues worldwide with the threatening potential to cause pandemics. In recent years, increasing levels of resistance to the four FDA approved antiinfl uenza virus drugs have been described. This situation underlines the urgent need for novel anti-virals in preparation for future infl uenza epidemics or pandemics. Although the anti-virals currently in use target viral factors such as the neuraminidase or the M2 ion channel, there is an increase in pre-clinical approaches that focus on cellular factors or pathways that directly or indirectly interact with virus replication. This does not only include inhibitors of virus-supportive signaling cascades but also interaction blockers of viral proteins with host cell proteins. This review aims to highlight some of these novel approaches that represent a paradigm change in anti-viral strategies against the infl uenza virus. Although most of these approaches are still in an early phase of preclinical development they might be very promising particularly with respect to the prevention of viral resistance to potential drugs.

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In Vivo Prophylactic Activity of QR-435 Against H3N2 Influenza Virus Infection

Abstract: QR-435 is effective for both prevention of H3N2 viral transmission and prophylaxis. These preclinical results warrant further evaluation of its prophylactic properties against avian influenza virus infection in humans.

Cited by 14 publications

References 31 publications

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Animal models for the study of influenza pathogenesis and therapy

Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections

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