In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing

Nutritional value and potential bioactivities of Pacific oyster (Crassostrea gigas)

“…The hydrolysate also reduced aspartate aminotransferase, alanine aminotransferase, malondialdehyde, glutathione, glutathione S-transferase and glutathione reductase. Shi et al (2015), Osaki et al (2016) and Lee et al (2021) demonstrated that the C. gigas components exerted hepatoprotective effects. These results indicated that C. gigas is a potential source of hepatoprotective agents and a functional food with high nutritional value and hepatoprotective activity.…”

“…(2016) and Lee et al . (2021) demonstrated that the C. gigas components exerted hepatoprotective effects. These results indicated that C. gigas is a potential source of hepatoprotective agents and a functional food with high nutritional value and hepatoprotective activity.…”

“…The hydrolysate of C. gigas is reported to exert hepatoprotective effects (Osaki et al, 2016;Lee et al, 2021). Osaki et al (2016) prepared C. gigas hydrolysate using water extraction and examined its hepatoprotective effect using ethanol-induced liver injury Wistar rat model by measuring the AST, ALT, MDA and CYP2E1 levels.…”

“…Lee et al . (2021) demonstrated the hepatoprotective effects of C. gigas hydrolysate using the ethanol intoxication‐induced liver injury mouse model. The C. gigas hydrolysate was prepared using the subcritical water method at 170 °C and 60 bar.…”

“…Several studies have reported the bioactive compounds of C. gigas , such as peptides (Je et al ., 2005; Han et al ., 2008; Liu et al ., 2008; Wang et al ., 2010; Hwang et al ., 2012; Cheong et al ., 2013; Seo et al ., 2013a, 2013b; Nam et al ., 2015; Hwang et al ., 2019), polysaccharides (Qian et al ., 2008; Shi et al ., 2015; Wang et al ., 2016; Zhang et al ., 2016; Cheong et al ., 2017; Hu et al ., 2017; Getachew et al ., 2019), oligosaccharides (Wu & Huang, 2017), polyphenols (Watanabe et al . 2012a) and lipids (Kim et al ., 2010), as well as those of C. gigas hydrolysate (Kim et al ., 2015; Osaki et al ., 2016; Lee et al ., 2018, 2021), mRNA (Sun et al . 2014), and powder (Bac et al ., 1998; Tanaka et al ., 2003).…”