In Vivo Quantitative Ultrasound on Dermis and Hypodermis for Classifying Lymphedema Severity in Humans

Omura, Masaaki; Saito, Wakana; Akita, Shinsuke; Yoshida, Kenji; Yamaguchi, Tadashi

doi:10.1016/j.ultrasmedbio.2021.12.003

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…QUS methods have been applied to various biological tissues, such as the skin, 16,17) breast, 18,19) blood vessels, [20][21][22] and lymph nodes. [23][24][25] The statistical properties of the echo envelope can be used to evaluate the number density and intensity of scatterers in tissues, and various generalized PDFs, such as Rayleigh, [26][27][28] K, 29,30) and Nakagami [31][32][33][34][35] distributions, have been investigated. In addition, an analytical model combining multiple statistical models has been proposed for the evaluation of complex echo signals.…”

Section: Introductionmentioning

confidence: 99%

Relationship between transmission/reception conditions of high-frequency plane wave compounding and evaluation accuracy of extended amplitude envelope statistics

Higa,

Ketterling,

Mamou

et al. 2024

Jpn. J. Appl. Phys.

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In previous studies, Double-Nakagami (DN) model, which is an amplitude envelope statistics method of quantitative ultrasound (QUS) was proposed for fatty liver evaluation, and the possibility of fatty property evaluation was suggested from the studies using a single concave transducer and rat livers. In this paper, five high-frequency linear array probes were used to investigate for clinical application. After confirmation of the influence of the sound field characteristics of the system and transmission/reception conditions on evaluation accuracy, QUS parameters were evaluated with DN model and other basic statistical models on fatty liver mimicking phantoms and rat livers. Correlations between fat gain and multiple QUS parameters were confirmed, suggesting that the combination of high-frequency linear array probes and a DN model may be a highly robust method for quantifying fatty liver.

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Section: Introductionmentioning

confidence: 99%

Relationship between transmission/reception conditions of high-frequency plane wave compounding and evaluation accuracy of extended amplitude envelope statistics

Higa,

Ketterling,

Mamou

et al. 2024

Jpn. J. Appl. Phys.

Self Cite

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show abstract

“…16,17) Examples of these techniques have been reported for various biological tissues, such as the liver, [18][19][20][21][22] skin, 23,24) and lymph nodes. 25,26) Especially for liver diagnosis, standardization studies of shear wave elastography and attenuation coefficient evaluation on clinical equipment are also actively underway. 27,28) Amplitude envelope statistics is a method for evaluating the intensity and number density of scatterers in tissue.…”

Section: Introductionmentioning

confidence: 99%

Improved robustness of multi-component analysis in amplitude envelope statistics using plane waves

Ujihara

Tamura

MORI

et al. 2023

Jpn. J. Appl. Phys.

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We compared the evaluation accuracy of amplitude envelope statistics under the transmission and reception conditions of compounded plane wave imaging (CPWI) and focused beam imaging (FBI). In a basic study using a homogeneous phantom, we found that the amplitude gradient in the depth direction and the PSF in the lateral direction spread in the FBI reduced the accuracy of evaluation in amplitude envelope statistics. On the other hand, CPWI showed a more stable evaluation than FBI because of the elimination of sound field characteristics. In CPWI, the multi-Rayleigh model discriminated signals from two types of scatterer with high accuracy in the evaluation using phantoms mimicking fatty liver. It was confirmed that the combination of CPWI and the multi-Rayleigh model is effective for detecting early fatty liver disease. The results show that CPWI is effective for improving the robustness of amplitude envelope statistics.

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Weighted ultrasound entropy imaging for HIFU ablation monitoring with improved sensitivity and contrast

Zhou,

Yang,

et al. 2024

Medical Physics

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BackgroundAlthough B‐mode imaging has been widely used in ultrasound‐guided high‐intensity focused ultrasound (HIFU) treatment, challenges remain in improving its quality and sensitivity for monitoring the thermal dose. Recently, quantitative ultrasound (QUS) imaging has been recognized with the potential to better sense the changes in the microstructure of ablated tissues.PurposeThis study proposed to use a QUS method called weighted ultrasound entropy (WUE) imaging to monitor the HIFU ablation.MethodsBased on ex‐vivo and in‐vivo experiments, WUE images reflecting tissue changes during HIFU treatment under different acoustic power levels (174–308 W) were reconstructed with a newly established imaging framework. The performance of the proposed WUE imaging in the monitoring of HIFU treatment was compared with the corresponding B‐mode images in terms of their contrast‐to‐noise ratios (CNRs) between the focal region and the background.ResultsIt was found that HIFU irradiation with higher power generated larger WUE values in the focal region, and the bright spots grew in size as the acoustic sonication proceeded. Compared with the in‐situ B‐mode images, the WUE images had higher image quality in indicating lesion formation, with a 39.2%–53.4% improvement in the CNR at different stages. Meanwhile, a correlation (R = 0.84) between the damage area estimated in WUE images and that measured from the dissected ex‐vivo tissue samples was found.ConclusionsWUE imaging is more sensitive and accurate than B‐mode imaging in monitoring HIFU therapy. These findings suggest that WUE imaging could be a promising technique for assisting ultrasound‐guided HIFU ablation.

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In Vivo Quantitative Ultrasound on Dermis and Hypodermis for Classifying Lymphedema Severity in Humans

Cited by 6 publications

References 49 publications

Relationship between transmission/reception conditions of high-frequency plane wave compounding and evaluation accuracy of extended amplitude envelope statistics

Relationship between transmission/reception conditions of high-frequency plane wave compounding and evaluation accuracy of extended amplitude envelope statistics

Improved robustness of multi-component analysis in amplitude envelope statistics using plane waves

Weighted ultrasound entropy imaging for HIFU ablation monitoring with improved sensitivity and contrast

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