In vivo radioimmunodetection of occult recurrent colonic carcinoma

Fh, DeLand; Ee, Kim; Fj, Primus; Me, Dine; Dm, Goldenberg

doi:10.2214/ajr.138.1.145

Cited by 15 publications

(5 citation statements)

References 5 publications

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“…Thus, in these nine cases RAID showed a sensitivity of 100%, whereas that for MRI was 33% and for CT 22% (later 78%). The successful detection by radiolabeled antibodies of carcinomas prior to subsequent confirmation by other diagnostic procedures has been documented (Goldenberg et al 1978;Goldenberg and DeLand 1982;DeLand et al 1982). In our experience RAID examinations have been requested when a rising plasma antigen titer associated with the particular carcinoma was present, yet other diagnostic evaluations did not indicate the location of the recurrent tumor.…”

Section: Discussionmentioning

confidence: 92%

Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection, X-ray computed tomography, and magnetic resonance imaging

et al. 1986

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In 12 consecutive patients with suspected metastatic carcinoma of the liver, we evaluated the sensitivity of radiolabeled antibodies to tumor antigens, magnetic resonance imaging, and X-ray computed tomography imaging in the detection of hepatic malignancies. Studies were performed with 131I labeled antibodies to CEA and/or CSAp; polyclonal, monoclonal and F(ab')2 antibodies were used. Nontarget radioactivity was diminished by administration of 99mTc reagents simulating nontumor distribution and use of a computer subtraction method. In nine patients with confirmed liver neoplasms, radioimmunodetection disclosed the foci of hepatic malignancies. In three patients with suspected liver neoplasms, the antibody studies were positive, but at this time have not been confirmed. X-ray computed tomography each disclosed mass lesions in five patients and magnetic resonance in three. These findings suggest that radioimmunodetection provides greater accuracy in the detection and localization of cancer than other diagnostic modalities currently used.

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Section: Discussionmentioning

confidence: 92%

Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection, X-ray computed tomography, and magnetic resonance imaging

et al. 1986

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“…This holds especially true for large solid tumours, but seems to be less of a problem for the treatment of small metastatic diseases. Interestingly, it has been shown that radioimmunodetection can provide information that could not be obtained by other methods and that this sometimes results in improved management of patients [8,17].…”

Section: Discussionmentioning

confidence: 99%

“…For diagnosis and therapy of SCC of the head and neck, monoclonal antibodies (mAbs) directed to tumour-associated cell-surface antigens are potentially powerful tools [7,16]. Among the potential applications of such tumour-preferential mAbs is their use as targeting agents for the selective delivery of radionuclides [2,8,11,12,17,20,22,27] or anti-tumour agents [2,9,10,15,25,37] to primary tumours and particularly to lymph node and distant metastases. Other approaches make use of unconjugated mAbs that eliminate tumour cells by activating immunological effector mechanisms, or mAbs that block mmour-associated processes, like proliferation and metastases, by binding to cell-surface receptors directly involved in these processes [13,33,36,37,39].…”

Section: Introductionmentioning

confidence: 99%

Potential for targeting head and neck squamous cell carcinoma with monoclonal antibody K984

Schrijvers

Gerretsen

Walsum

et al. 1992

Cancer Immunol Immunother

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In previous reports we have described the development of mAb K984, reactive with an epitope expressed on the outer cell surface of undifferentiated, proliferating cells in normal stratified squamous epithelia and their neoplastic counterparts. The K984 antigen was also found to be homogeneously expressed by in vitro cultured squamous cell carcinoma (SCC) cell lines. In the present study we demonstrate that mAb K984 induces a significant, dose-dependent growth inhibition when SCC cells are grown in vitro as monolayer cultures in the presence of mAb K984. These data seem to indicate that mAb K984 has potential for tumour targeting, especially in a therapeutic setting. As a first approach to evaluate the suitability of mAb K984 for tumour targeting in vivo, radiolabelled mAb K984 was administered to SCC-xenografted nude mice. Selective tumour accumulation of mAb K984 was observed. Tumour to blood ratios and tumour to non-tumour ratios, as based on the biodistribution data, were at least ten times higher in case of the specific mAb K984 when compared to another non-specific, isotype-matched control antibody. mAb K984 was also capable of visualizing tumour deposits in xenografted nude mice. The corollary of these findings is that the mAb K984-defined antigen probably is involved in the regulation of proliferation of stratified squamous epithelium and squamous cell carcinoma and that mAb K984 has potential for specific tumour targeting.

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“…The typical lower limit of tumor resolution is roughly 1.5 cm, but tumors as small as 0.4 cm have been detected. The tumor markers targeted in these studies include CEA [63,64,66,67], a melanoma-associated antigen [68], and protooncogene products such as c-erbB [69,70] and cmyc [71]. It is clear that this method will require further investigation to optimize antibody delivery to tumor markers, but it is also quite clear that in the future radioimmunoimaging via tumor markers may have a profound impact on the early detection of cancer.…”

Section: Tumor Markers and The Radioimmunological Early Detection Of mentioning

confidence: 99%

The role of tumor markers in the early detection of cancer

Humphrey

1989

Seminars in Surgical Oncology

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Tumor markers include a broad range of substances expressed at different levels and in different biochemical forms. Bence-Jones protein, carcino-embryonic antigen and alpha-fetoprotein are recognized as some of the earlier utilized markers. Recent technologic advances have led to the development of a variety of serum tumor markers, tumor markers in body fluids, tissue tumor markers, and genetic tumor markers, such as protooncogenes.

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In vivo radioimmunodetection of occult recurrent colonic carcinoma

Cited by 15 publications

References 5 publications

Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection, X-ray computed tomography, and magnetic resonance imaging

Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection, X-ray computed tomography, and magnetic resonance imaging

Potential for targeting head and neck squamous cell carcinoma with monoclonal antibody K984

The role of tumor markers in the early detection of cancer

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