In vivo recovery and survival of apheresis and whole blood‐derived platelets: a paired comparison in healthy volunteers

Abstract

Filter-LR PRP platelet preparation appears to adversely affect platelet recovery and survival characteristics. The reasons for this effect are not clear. These results may not apply to all apheresis and PRP methods of platelet preparation.

Efficacy and Adverse Events of Platelet Transfusion – Product-Specific Differences

“…It found reduced platelet refractoriness rates to be associated with transfusing filtered apheresis platelets [23]. This agrees with recent studies suggesting higher success rates after transfusion of APC compared with PPC [8,9]. However, prospective controlled trials are needed to find out whether there are differences in clinical efficacy between leukodepleted PPC and APC or not.…”

“…The authors observed CCI values of ≥4.5 × 10 9 platelets/l in 35% for the WBC-reduced PPC and in 53% for APC (p < 0.0001). The same study group performed a prospective crossover trial examining in vivo recovery and survival of autologous WBC-reduced apheresis platelets and autologous leukoreduced platelets prepared from whole blood, both preparations stored for 5 days, in 22 healthy volunteers [9]. The apheresis platelets had a 18.8% better recovery and survived 32.9% longer than did platelets prepared from whole blood.…”

Evaluation of store lesion in platelet obtained by apheresis compared to platelet derived from whole blood and its impact on the in vitro functionality

“…Unfortunately, the manual technique implies strong manipulation of blood components, increasing the risk of platelet activation and storage lesion [5,6]. Alternatively, platelets can be obtained by apheresis, where each apheresis dose is equivalent to 6 whole blood-derived units and one can collect 1, 2 or 3 apheresis doses of platelet concentrate from a single donor using a cell separator, diminishing manipulation [7,8]. Additionally, platelets obtained by apheresis can be re-suspended in plasma or additive solution [9][10][11].…”

2 Platelet Concentrates

“…PCs obtained by the platelet-rich plasma method (which are not used in Germany) have a reduced platelet recovery and survival compared to apheresis platelet preparations [2]. Also refractoriness developed less frequently with apheresis concentrates [64].…”