In vivo selective monitoring of basal levels of cerebral dopamine using voltammetry with Nafion modified (NA-CRO) carbon fibre micro-electrodes

Crespi, Francesco; Möbius, Claudia

doi:10.1016/0165-0270(92)90094-t

Cited by 41 publications

(24 citation statements)

References 33 publications

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“…This might be because the surface of the hair-derived carbon is slightly negatively charged, attracting positively charged dopamine [37,38]. These results imply that the electrode modified with human hair-derived hollow carbon microfibers is suitable M A N U S C R I P T…”

Section: Accepted Manuscriptmentioning

confidence: 92%

Human hair-derived hollow carbon microfibers for electrochemical sensing

Pramanick

Cadenas

Kim

et al. 2016

Carbon

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Section: Accepted Manuscriptmentioning

confidence: 92%

Human hair-derived hollow carbon microfibers for electrochemical sensing

Pramanick

Cadenas

Kim

et al. 2016

Carbon

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“…Pt-Nafion ® (5/2) sensors incorporate an annealed form of the perfluorinated sulfonic acid ionomer on the electrode surface which has demonstrated excellent rejection characteristics previously [8]. In the past Nafion ® has been employed in electrochemical sensor design for its dual ability as both a cation exchange polymer [32][33][34][35] and an anionic rejection layer [4][5][6]. However, the described Nafion ® pre-coat method displays both anionic and cationic rejection characteristics while facilitating the diffusion of gaseous molecules such as NO and O2 to the electrode surface.…”

Section: Shelf-life Studies-effect Of Repeated Aa Calibrationsmentioning

confidence: 99%

Ascorbic Acid Rejection Characteristics of Modified Platinum Electrodes: A Shelf Life Investigation

Wynne

Finnerty

2015

Chemosensors

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Ascorbic acid (AA) is the principle interferent present in brain extracellular fluid that can inhibit the ability of electrochemical sensors to selectively detect a particular analyte of interest. Considerable efforts have been made in recent times to develop highly selective membrane coatings to counteract the drawbacks associated with AA interference during in vivo monitoring. The primary objective of the work described within was to investigate the long term effect of storing such selective membranes, i.e., Nafion ® andPoly-o-phenylenediamine (PPD) under different conditions and how exposing them to repeated calibration protocols compromises the membranes ability to reject AA. Four different modified platinum (Pt) electrodes, Pt-PPD, Pt-Nafion ® (5/2), Pt-Nafion ® (1/2)-PPD, and Pt-Nafion ® (2/1)-PPD, stored at 4 °C demonstrated deterioration of the polymers integrity when exposed to repeated calibrations. On the contrary, exposing the same four electrode types to single calibrations confirmed excellent retention of AA rejection characteristics. Pt-PPD electrodes were then exposed to varying storage conditions and calibrated against AA on day 1, day 56 and day 168. Storing the Pt-PPD electrodes at 4 °C/N2 saturated glass container demonstrated retention of AA rejection characteristics after day 168. These results have clearly elucidated the optimum storage conditions for Pt-Nafion ® and Pt-PPD modified electrodes.

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“…The exposed fibers were repeatedly coated with a 5% solution of Nafion (Aldrich, Milwaukee, WI), a perfluorinated ionomer that promotes the exchange of cations such as DA while impeding the exchange of interfering anionic species such as ascorbic acid (AA) and 3,4-dihydroxyphenylacetic acid (Capella et al 1990;Crespi and Moebius 1992;Gerhardt et al 1984). Each electrode was calibrated before implantation to determine its sensitivity to DA and its selectivity for DA compared to AA.…”

Section: In Vivo Electrochemistrymentioning

confidence: 99%