In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications

Greenhalgh, Kerriann; Turos, Edward

doi:10.1016/j.nano.2008.07.004

Cited by 55 publications

(32 citation statements)

References 44 publications

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“…Polymeric nanoparticles in particular are steadily gaining importance in medicine because of their long half-life in the blood stream (9,10) and the versatility by which their composition, size, shape, and physicochemical properties (11) may be tuned via a variety of processing approaches. Recent medical achievements based on the use of polymer particles in specific applications include the targeted delivery of drugs and toxins using surface-conjugated biodegradable polymer particles (12,13), treatment of antibiotic-resistant bacterial infections (14,15), and induction of regulatory T cells for treatment of multiple sclerosis (16).…”

mentioning

confidence: 99%

In-fiber production of polymeric particles for biosensing and encapsulation

Kaufman

Ottman²,

Tao

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Polymeric micro-and nanoparticles are becoming a mainstay in biomedicine, medical diagnostics, and therapeutics, where they are used in implementing sensing mechanisms, as imaging contrast agents, and in drug delivery. Current approaches to the fabrication of such particles are typically finely tuned to specific monomer or polymer species, size ranges, and structures. We present a general scalable methodology for fabricating uniformly sized spherical polymeric particles from a wide range of polymers produced with complex internal architectures and continuously tunable diameters extending from the millimeter scale down to 50 nm. Controllable access to such a wide range of sizes enables broad applications in cancer treatment, immunology, and vaccines. Our approach harnesses thermally induced, predictable fluid instabilities in composite core/cladding polymer fibers drawn from a macroscopic scaled-up model called a "preform." Through a stack-and-draw process, we produce fibers containing a multiplicity of identical cylindrical cores made of the polymers of choice embedded in a polymer cladding. The instability leads to the breakup of the initially intact cores, independent of the polymer chemistry, into necklaces of spherical particles held in isolation within the cladding matrix along the entire fiber length. We demonstrate here surface functionalization of the extracted particles for biodetection through specific protein-protein interactions, volumetric encapsulation of a biomaterial in spherical polymeric shells, and the combination of both surface and volumetric functionalities in the same particle. These particles used in distinct modalities may be produced from the desired biocompatible polymer by changing only the geometry of the macroscopic preform from which the fiber is drawn.

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mentioning

confidence: 99%

In-fiber production of polymeric particles for biosensing and encapsulation

Kaufman

Ottman²,

Tao

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…The study demonstrated favorable activity of the nanoparticle channeled drug system for systemic or topical application in a murine model. It was also shown that both routes were promising, and when topically applied, the emulsion enhanced wound healing by an average of 3-5 days [ 65 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

“…In one set of in vivo studies, polyacrylate nanoparticle emulsions were used for topical wound healing or systemic applications [ 65 ]. This study found that the antibiotic-conjugated polyacrylate nanoparticles had activity against MRSA in vitro and no cytotoxicity against human dermal cells.…”

Section: Antimicrobial Nanoparticles Improve Wound Repairmentioning

confidence: 99%

Tissue Engineering In Vivo with Nanotechnology

et al. 2014

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“…Penicillin-conjugated polyacrylate NPs have shown in vitro antibacterial activity against MRSA with no cytotoxicity toward human dermal cells and in vivo when applied to a dermal abrasion murine model (Greenhalgh and Turos, 2009).…”

Section: Topicalmentioning

confidence: 99%

Nanocarriers Against Bacterial Biofilms

Nafee

2015

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

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In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications

Cited by 55 publications

References 44 publications

In-fiber production of polymeric particles for biosensing and encapsulation

In-fiber production of polymeric particles for biosensing and encapsulation

Tissue Engineering In Vivo with Nanotechnology

Nanocarriers Against Bacterial Biofilms

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