In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy

Lung, Pam Wen; Tippavajhala, Vamshi Krishna; Mendes, Thiago de Oliveira; Téllez-Soto, Claudio A.; Schuck, Desirée Cigaran; Brohem, Carla Abdo; Lorencini, Márcio; Martin, Aírton Abrahão

doi:10.1007/s10103-017-2431-3

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Rough skin surface and less elasticity are related to dermal density, such as in fibrillin, elastin, and collagens. Dermal fiber networks of SD are modified with a decrease in the elastic fibers in the papillary dermis, and collagen networks are also modified and reduced in SD skin . We identified the reduced echo‐density in the dermis of SD skin in Figure G,H, and Figure showed a decreased echo‐density in the dermis of SD skin.…”

Section: Discussionmentioning

confidence: 78%

“…Dermal fiber networks of SD are modified with a decrease in the elastic fibers in the papillary dermis, and collagen networks are also modified and reduced in SD skin. [20][21][22] We identified the reduced echo-density in the dermis of SD skin in Figure 2G,H, and Figure 4 showed a decreased echo-density in the dermis of SD skin. The SD skin had the higher collagen degeneration and lower structures of collagen and elastic fibers than adjacent normal skin.…”

Section: Discussionmentioning

confidence: 90%

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Biophysical properties of striae rubra and striae alba in human skin: Comparison with normal skin

Cho¹,

Cho²,

Kim³

et al. 2018

Skin Research and Technology

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Background Striae distensae are common dermal lesions that progress through two different stages: the striae rubra, which appears to be erythematous, and striae alba, which is characterized by a hypopigmented feature. The clinical characteristics between striae distensae stages and normal skin remain unknown. Objectives We aimed to investigate the clinical characteristics according to stages of striae distensae in terms of their biophysical properties, using objective noninvasive measurements in comparison with adjacent normal skin. Methods Sixty‐one healthy female subjects with striae distensae were included as follows: 30 with striae rubra and 31 with striae alba on the abdomen and thighs. Hydration of the epidermis and dermis, skin color brightness, and Erythema index were measured. Skin elasticity, roughness, and dermal echo‐density of the skin with striae distensae and adjacent normal skin were also measured. Results Hydration of the epidermis and dermis showed no significant difference between the skin with striae distensae and normal skin. Brightness of skin with striae alba and normal skin was significantly higher than that of skin with striae rubra. Erythema index of skin with striae rubra was significantly higher than that of skin with striae alba and normal skin. Skin with striae rubra and striae alba had a rougher surface than normal skin. Elasticity and dermal echo‐density were significantly lower in striae distensae skin. Conclusions Striae rubra and striae alba had similar biophysical properties in terms of skin hydration, elasticity, roughness, and dermal density. Moreover, striae distensae have less elasticity, more roughness, and lower dermal density than normal skin.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 90%

Biophysical properties of striae rubra and striae alba in human skin: Comparison with normal skin

Cho¹,

Cho²,

Kim³

et al. 2018

Skin Research and Technology

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“…From the 200 spectra of the five groups obtained, the intensity of characteristic peaks of dyes and fibres was acquired. Baselines of the spectra were normalised against the fibre peaks at 1095 cm −1 ( I Dyes /I Fibres ; I Dyes represents the Raman intensity of the dye peak at 1577 cm −1 and I Fibres represents the Raman intensity of the fibre peak at 1095 cm −1 ), 30,52 to avoid the influence of intensity attenuation on the scattering signal when the laser beam irradiated to the inner fibre.…”

Section: Methodsmentioning

confidence: 99%

A study of the diffusion behaviour of reactive dyes in cellulose fibres using confocal Raman microscopy

Yang

Dai

Zhong

et al. 2020

Coloration Technology

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Confocal Raman microscopy was used as a non‐destructive tool for in situ investigation of the diffusion of CI Reactive Blue 194 in viscose fibres. Dyed fibres were analysed by Raman depth imaging along the radius at different dyeing times (30, 60, 90, 120, 150, 180, 240, 300, 600, 900, 1200, 1500, 1800, 2100 and 2400 seconds) and temperatures (30, 40, 50, 60, 70 and 80°C). The dye concentration in the fibre was expressed by normalising the characteristic peak of dyes at 1577 cm−1 to eliminate the interference of the fibre. The Raman depth mapping images showed that dye molecules gradually diffused to the interior of the fibre with an increase in dyeing time, remaining ring‐shaped in the state of diffusion. In addition, the diffusion rate increased with increases in the dyeing temperature. This was understandable because dye molecules with a higher kinetic energy move faster. It was also found that the external structure of fibres played a significant role in the diffusion behaviour of CI Reactive Blue 194 during the initial stage of dyeing. The concentration gradient distribution of CI Reactive Blue 194 in the fibre was reflected by Raman depth mapping. The study demonstrates the potential of confocal Raman microscopy for monitoring the dynamic diffusion of dye molecules in fibres.

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“…Thus, seeking to acquire more effective products with claims in stimulating endogenous HA production, confocal Raman spectroscopy (CRS), a technique with high capacity to biochemically characterize biological tissues quickly and accurately, has been used in various evaluations. Furthermore, the fact that CRS does not require invasive procedures or treatment makes it an important tool for measuring the effects of cosmetic products [15][16][17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

In vivo analysis of endogenous hyaluronic acid in the dermis by confocal Raman spectroscopy after application of a dermocosmetic

Medeiros Neto,

Bachion de Santana,

Modesto de Almeida

et al. 2024

Biomedical Spectroscopy, Microscopy, and Imaging III

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Evaluating endogenous hyaluronic acid (HA) in the skin is essential to understanding the ageing process and analysing the effectiveness of dermocosmetics. In this sense, this study evaluated the skin of 10 individuals between 51 and 65 years old before and after applying a dermocosmetic to stimulate HA production. For this, Gen2 confocal Raman (Rivers Diagnostic) coupled to a 785 nm laser was used. Participants underwent a 7-day washout and then had their skin measured (T0control). After the control measure, they used the product for 60 days, applying it twice a day (morning and evening). Measurements were made at times T0, T30 and T60 days in the spectral range of 400 to 1800 cm -1 . Spectral data was processed by removing the baseline, smoothing and vector normalization. The T30 and T60 spectra were subtracted from the control measurement (T0) and compared with the second derivative spectrum of hyaluronic acid. It was observed that the main peaks of HA were presented in the difference between the spectra before and after using the dermocosmetic. The main peaks observed were 1076, 1084, 1096, 1126, 1132 and 1208 cm -1 . The difference between these peaks increased after 30 and 60 days of using the dermocosmetic product, indicating an increase in the concentration of HA in the skin. Therefore, the in vivo assessment of cutaneous HA by confocal Raman spectroscopy can be used to understand the role of dermocosmetics in skin ageing, allowing for more effective treatments.

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In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy

Cited by 6 publications

References 62 publications

Biophysical properties of striae rubra and striae alba in human skin: Comparison with normal skin

Biophysical properties of striae rubra and striae alba in human skin: Comparison with normal skin

A study of the diffusion behaviour of reactive dyes in cellulose fibres using confocal Raman microscopy

In vivo analysis of endogenous hyaluronic acid in the dermis by confocal Raman spectroscopy after application of a dermocosmetic

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