In vivo study on scaffolds based on chitosan, collagen, and hyaluronic acid with hydroxyapatite

Kaczmarek, Beata; Sionkowska, Alina; Gołyńska, Magdalena; Polkowska, Izabela; Szponder, Tomasz; Nehrbass, Dirk; Osyczka, Anna M.

doi:10.1016/j.ijbiomac.2018.06.175

Cited by 49 publications

(28 citation statements)

References 23 publications

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“…There are only a few papers in the scientific literature regarding hyaluronic acid blends with other natural polymers and synthetic polymers where interactions between biopolymers in mixtures have been scarcely described. Nevertheless, the interactions between collagen, hyaluronic acid, and chitosan in mixtures and materials based on collagen/hyaluronic acid/chitosan blend have been studied within the last 5 years [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ] and new materials have been proposed.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Such materials have potential in bone repair and in bone tissue engineering. It seems that 3D porous composites based on blends of chitosan, collagen, and hyaluronic acid can also be considered as a matrix for the incorporation of inorganic particles [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. Additional crosslinking of such composites may offer materials with good biocompatibility and mechanical properties, which can be proper in bone tissue engineering.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Although the biological properties in vivo of single natural polymers are widely researched, the behavior and influence of tricomponent–biopolymer composites on cell morphology, differentiation, and function in living organisms are not yet well known. For collagen/chitosan/hyaluronic acid composites, the adhesion and proliferation of human osteosarcoma SaOS-2 cells on the scaffolds have been studied and the biocompatibility of the chosen scaffolds has been further studied by their in vivo implantation into the subcutaneous tissue of rabbits [ 74 ]. The obtained results suggest that the stability of such scaffolds is rather low.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Polymer blends can be also turned into 3D structures, such as foams and scaffolds [ 68 , 69 , 70 , 71 , 72 , 87 , 88 , 89 ]. In such 3D structures, inorganic particles can be incorporated, and in such a way, one can obtain materials, which can mimic a bone tissue [ 72 , 74 ]. Incorporation of magnetic particles into the biopolymer blends can lead to new materials, which can be used in biomedical applications, such as: tissue repair, drug delivery, magnetic resonance imaging (MRI), hyperthermia, magnetofection, and cellular therapy [ 78 , 90 , 91 , 92 , 93 ].…”

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

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Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

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Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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“…HA has good biological activity and biocompatibility (Yousefi, Oudadesse, Akbarzadeh, Wers, & Lucas-Girot, 2014). After implantation, HA can form a chemical combination with the hard and soft tissues of the human body (Chang et al, 2000;Kaczmarek et al, 2018). However, it is now mostly used in nonbearing sites, such as artificial tooth root, skull bone, and bone-defect filling, due to drawbacks of HA brittleness, low flexural strength, and low impact resistance (Chen, Shi, Zhang, & Ma, 2019;Muralithran & Ramesh, 2000;Zhang et al, 2019).…”

mentioning

confidence: 99%

Direct 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds for customized mechanical properties and biological functions

Zhou

et al. 2020

J Tissue Eng Regen Med

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Customized scaffold plays an important role in bone tissue regeneration. Precise control of the mechanical properties and biological functions of scaffolds still remains a challenge. In this study, metal and ceramic biomaterials are composited by direct 3‐D printing. Hydroxyapatite (HA) powders with diameter of about 25 μm and Ti‐6Al‐4V powders with diameter of 15–53 μm were mixed and modulated for preparing 3‐D printing inks formulation. Three different proportions of 8, 10, and 25 wt.% HA specimens were printed with same porosity of 72.1%. The green bodies of the printed porous scaffolds were sintered at 1,150°C in the atmosphere of argon furnace and conventional muffle furnace. The porosities of the final 3‐D‐printed specimens were 64.3 ± 0.8% after linear shrinkage of 6.5 ± 0.8%. The maximum compressive strength of the 3‐D‐printed scaffolds can be flexibly customized in a wide range. The maximum compressive strength of these scaffolds in this study ranged from 3.07 to 60.4 MPa, depending on their different preparation process. The phase composition analysis and microstructure characterization indicated that the Ti‐6Al‐4V and HA were uniformly composited in the scaffolds. The cytocompatibility and osteogenic properties were evaluated in vitro with rabbit bone marrow stromal cells (rBMSCs). Differentiation and proliferation of rBMSCs indicated good biocompatibility of the 3‐D‐printed scaffolds. The proposed 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds with tunable mechanical and biological properties in this study is a promising candidate for bone tissue engineering.

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PCL/collagen blends prepared by solution blow spinning as potential materials for skin regeneration

Lorente

Corral

González‐Benito

2021

J of Applied Polymer Sci

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Solution blow spinning (SBS), is used to prepare biocompatible fibrous materials based on poly-ε-caprolactone (PCL), modified with collagen. Materials with different compositions in terms of collagen are prepared. Structure, morphology, topography, wettability behavior, and cytotoxicity are studied in order to investigate the potentiality of these materials for medical applications in the field of tissue repairing and regeneration. Structure is studied by Fourier transformed infrared spectroscopy, morphology by scanning electron microscopy, topography by optical profilometry and wettability behavior by contact angle measurements. The addition of small amounts of collagen to PCL by SBS can induce important variations in the morphology and topography of the materials that, in turns, lead to changes in the wettability behavior and ability of HaCat cells adhesion and proliferation. The analysis of surface characteristics together with the use of a model based on mats constituted by cylinders disposed perpendicularly to each other point out that, under the compositions considered, the main factor leading to higher adhesion and proliferation of cells on the PCL/collagen is the presence of more available surface area.

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In vivo study on scaffolds based on chitosan, collagen, and hyaluronic acid with hydroxyapatite

Cited by 49 publications

References 23 publications

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Direct 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds for customized mechanical properties and biological functions

PCL/collagen blends prepared by solution blow spinning as potential materials for skin regeneration

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