In vivo targeted peripheral nerve imaging with a nerve-specific nanoscale magnetic resonance probe

Zheng, Linfeng; Li, Kangan; Han, Yuedong; Wei, Wei; Zheng, Sujuan; Zhang, Guixiang

doi:10.1016/j.mehy.2014.08.013

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…Therefore, there is a pressing medical need for the development of reliable and reproducible, non-invasive imaging strategies [320]. Such imaging strategies must have adequate spatial and temporal resolution for the early and exact diagnosis assessment of PNI as well as continued monitoring after treatment [321]. Consistent, harmless, noninvasive and reproducible methodologies that aid in the determination of the injury degree and nature are required for the correct diagnosis, for instance to help in finding the exact location where changes in the normal nerve anatomy occurred.…”

Section: Nanotheranostics and Imagingmentioning

confidence: 99%

“…They are highly biologically inert and easily detected by MRI [333]. Table 11 summarizes the approaches envisioned for nanotheranostics and nanoimaging comprising nanotechnology in the field of PN regeneration [321,[334][335][336][337][338][339]. Also, Figure 10 reveals some of the most exciting results obtained in the field of theranostics and nano-imaging.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Zheng et al, [321] described a molecular and nano-scale imaging methodology, namely molecular and cellular MRI (MCMRI). Based on the fact that there are cellular and molecular changes on the nervous system, both at proximal and distal sites after an injury,…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Nanotechnology in peripheral nerve repair and reconstruction

Carvalho

Silva‐Correia

Oliveira

et al. 2019

Advanced Drug Delivery Reviews

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The recent progress in biomaterials science and development of tubular conduits (TCs) still fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in particular when disease-related and long-gap defects need to be addressed.Nanotechnology-based therapies that seemed unreachable in the past are now being considered for the repair and reconstruction of PNIs, having the power to deliver bioactive molecules in a controlled manner, to tune cellular behavior, and ultimately guide tissue regeneration in an effective manner. It also offers opportunities in the imaging field, with a degree of precision never achieved before, which is useful for diagnosis, surgery and in the patient's follow-up. Nanotechnology approaches applied in PNI regeneration and theranostics, emphasizing the ones that are moving from the lab bench to the clinics, are herein overviewed.

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Section: Nanotheranostics and Imagingmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Nanotechnology in peripheral nerve repair and reconstruction

Carvalho

Silva‐Correia

Oliveira

et al. 2019

Advanced Drug Delivery Reviews

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“…However, it is only effective for superficial nerves in the examination of peripheral nerves (PNs). High‐resolution US is not suitable for nerve visualization at increased tissue depth and hyperechoic structures; less than 30% of the true number of nerve fascicles is actually detected on US [2a,6] …”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation

2020

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Accidental transection or injury of nerves during surgeries leads to severe patient morbidity and lowers the life quality of patients. The current imaging modality for nerves, such as magnetic resonance imaging (MRI), computerized tomography (CT), and high-resolution ultrasound, cannot provide real-time guidance for surgeons during surgical operations. Previously, intraoperative nerve recognition mainly depended on the surgeon's experience. But now, optical imaging techniques that exploit fluorescent light enable the direct intraoperative visualization of the areas of interest on a surgical site, which has the potential to improve real-time nerve identification during surgeries. Herein, a brief introduction is provided to the structure of peripheral nerve (PN) fiber and fluorescent probes for nerve labeling that are based on these features are summarized. Then, the recent progress in fluorescence-guided surgeries for nerve preservation is systematically summarized. Finally, the challenges and future opportunities for in vivo real-time nerve identification are discussed.

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Nanotechnology and Nanomaterials in Peripheral Nerve Repair and Reconstruction

et al. 2022

Nanomedicine

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In vivo targeted peripheral nerve imaging with a nerve-specific nanoscale magnetic resonance probe

Cited by 6 publications

References 48 publications

Nanotechnology in peripheral nerve repair and reconstruction

Nanotechnology in peripheral nerve repair and reconstruction

Recent Advances in Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation

Nanotechnology and Nanomaterials in Peripheral Nerve Repair and Reconstruction

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