in vivo targeting of colloidal carriers by novel graft copolymers

Arshady, Reza

doi:10.1002/(sici)1099-1352(199634/12)9:5/6<536::aid-jmr297>3.0.co;2-s

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…For example, the bulk PEG hydrogels are unable to respond to external temperature stimulations, whereas our PNIPAAm nanoparticle hydrogel networks can. In addition, nanoparticles have difficulty in reaching the target sites and a short time in circulating after the delivery due to the rapidly removal of the reticuloendothelial system (RES) as found in several studies (42–45). PNIPAAm nanoparticles also react quickly to an external stimulus and are too small for some practical applications (39).…”

Section: Discussionmentioning

confidence: 99%

Development of a Temperature-Sensitive Composite Hydrogel for Drug Delivery Applications

et al. 2006

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To develop materials with improved controllability and specificity, we have investigated composite hydrogels with temperature-sensitive properties using photo cross-linking. Specifically, our novel composite materials are composed of nanoparticles made of poly(N-isopropylacrylamide) (PNIPAAm), temperature-sensitive hydrogels, and a photo cross-linker, poly(ethylene glycol) diacrylate (PEGDA). PNIPAAm particles were synthesized by emulsion polymerization and by varying concentration of four main factors: monomers (N-isopropylacrylamide), cross-linkers (N,N'-methylenebisacrylamide), surfactants (sodium dodecyl sulfate, SDS), and initiators (potassium persulfate). We found that the surfactant, SDS, was the most important factor affecting the particle size using the factorial design analysis. Additionally, both nano- and micro-PNIPAAm particles had excellent loading efficiency (>80% of the incubated bovine serum albumin (BSA)), and their release kinetics expressed an initial burst effect followed by a sustained release over time. Furthermore, BSA-loaded PNIPAAm nanoparticles were used to form three-dimensional gel networks by means of a photocuring process using a photo cross-linker, PEGDA, and a photoinitiator, Irgacure-2959 (I-2959). Results from scanning electron microscopy and in vitro BSA release studies from these hydrogels demonstrated that PNIPAAm nanoparticles were embedded inside the PEG polymeric matrix and the composite material was able to release BSA in response to changes in temperature. These PNIPAAm nanoparticle hydrogel networks may have advantages in applications of controlled drug delivery systems because of their temperature sensitivity and their ability of in situ photopolymerization to localize at the specific region in the body.

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Section: Discussionmentioning

confidence: 99%

Development of a Temperature-Sensitive Composite Hydrogel for Drug Delivery Applications

et al. 2006

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“…Therefore, we used the emulsific-aggregation method to prepare the biodegradable albendazole-polybutyl cyanocrylate nanoparticle(ABZ-PBCA-NP), butyl cyanocrylate (BCA) as the polymeric monomer. Animal studies suggest that nanoparticle can significantly improve abendazole bioavailability and hepatic target ability [6]. For albendazole nanoparticle's notable dispersibility and unsteability of aggregation and sedimentation, we studied the drug-load mechanism of albendazole polybutylcyanocrylate with isotherm-adsorption method; determined the aggregation dynamics though conductance and selected suitable assistant suspension to improve physical stability.…”

Section: Intruductionmentioning

confidence: 99%

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Xue-nong

Gong²,

Tang³

et al. 2008

CNANO

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Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole-polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution.

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“…In vivo, if the particle diameter of the nanoparticles is less than 200nm, it can be captured by reticuloendothelial system, especially by the Kupffer cell in the liver. In this paper [6], we employed the ABZ as the basic remedy, and butycyanocrylate (BCA) as the drug carrier to prepare the albendazole polybutylcyanoacrylate nanoparticles (ABZ-PBCA-NP) and albendazole polyvinyl pyrrolidone polybutylcyanoacrylate nanoparticles (PVP-ABZ-PBCA-NP),…”

Section: Introductionmentioning

confidence: 99%

Alternative Albendazole Polybutylcyanoacrylate Nanoparticles Preparation, Pharmaceutical Properties and Tissue Distribution in Rats

Xue-nong

Tang²,

Gong³

et al. 2006

LDDD

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Two loaded nanoparticles, albendazole polybutylcyanoacrylate nanoparticles (ABZ-PBCA-NP) and albendazole polyvinylpyrrolidone. Polybutylcyanoacrylate nanoparticles (ABZ-PVP-PBCA-NP) were prepared by the emulsification-polymerization method. Tissue distribution and tissue targeting of ABZ-PBCA-NP in mice was studied. The drug-load mechanism of ABZ-PBCA-NP was studied by the equal-temperature absorption principle. The drug loaded in nanoparticle was coincident with the Langmuir adsorption equation. The dialyzed dynamic of albendazole from four formulations, ABZ-PBCA-NP, PVP-ABZ-PBCA-NP, ABZ suspension (SABZ) and ABZ liquid (LABZ), was investigated in vitro. ABZ-PBCA-NP and PVP-ABZ-PBCA-NP were suitable for the Higuchi and bi-exponent function respectively. The absorptive capability of the drug was enhanced when 4% PVP was added into the nanoparticle, and its release time was increased. The tissue distribution of albendazole in different drug vehicles was studied by isotope labeling experiment. Targeting index of albendazole in liver and spleen in mice was estimated at 11.4 and 3.9 after ig 3 H-ABZ-PBCA-NP. The bioavailability of albendazole nanoparticle and suspension was 76.0% and 36.9%, respectively. The results have shown that the nanoparticle vehicles increase the albendazole bioavailability.

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in vivo targeting of colloidal carriers by novel graft copolymers

Cited by 3 publications

References 22 publications

Development of a Temperature-Sensitive Composite Hydrogel for Drug Delivery Applications

Development of a Temperature-Sensitive Composite Hydrogel for Drug Delivery Applications

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Alternative Albendazole Polybutylcyanoacrylate Nanoparticles Preparation, Pharmaceutical Properties and Tissue Distribution in Rats

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