In vivo terahertz imaging of rat skin burns

Tewari, Priyamvada; Kealey, Colin P.; Bennett, David; Bajwa, Neha; Barnett, Kelli S; Singh, Rahul; Culjat, Martin O.; Stojadinovic, Alexander; Grundfest, Warren S.; Taylor, Zachary D.

doi:10.1117/1.jbo.17.4.040503

Cited by 77 publications

(53 citation statements)

References 19 publications

(22 reference statements)

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“…Given the permittivity of the sample and the dehydrated tissue, also called the biological background, the volume fraction (14,15) and stratified media theory can be used to calculate the reflectivity of samples resembling multi-layer structures (16). This approach has been used successfully in vivo on both rat skin (17) and rabbit cornea (18)(19)(20). The Bruggeman model is also used to estimate the safety thresholds in the THz range of skin and cornea (21).…”

Section: Tissue Modellingmentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

229

113

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Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

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Section: Tissue Modellingmentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

229

113

View full text Add to dashboard Cite

show abstract

“…The first successful demonstration of in vivo THz imaging of a disease process was achieved by Tewari et al 16 in 2011. This study evaluated partial and full-thickness burns on SD rats.…”

Section: Introductionmentioning

confidence: 99%

Assessment of corneal hydration sensing in the terahertz band:in vivoresults at 100 GHz

Bennett¹,

Taylor²,

Tewari³

et al. 2012

J. Biomed. Opt

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Abstract. Terahertz corneal hydration sensing has shown promise in ophthalmology applications and was recently shown to be capable of detecting water concentration changes of about two parts in a thousand in ex vivo corneal tissues. This technology may be effective in patient monitoring during refractive surgery and for early diagnosis and treatment monitoring in diseases of the cornea. In this work, Fuchs dystrophy, cornea transplant rejection, and keratoconus are discussed, and a hydration sensitivity of about one part in a hundred is predicted to be needed to successfully distinguish between diseased and healthy tissues in these applications. Stratified models of corneal tissue reflectivity are developed and validated using ex vivo spectroscopy of harvested porcine corneas that are hydrated using polyethylene glycol solutions. Simulation of the cornea's depth-dependent hydration profile, from 0.01 to 100 THz, identifies a peak in intrinsic reflectivity contrast for sensing at 100 GHz. A 100 GHz hydration sensing system is evaluated alongside the current standard ultrasound pachymetry technique to measure corneal hydration in vivo in four rabbits. A hydration sensitivity, of three parts per thousand or better, was measured in all four rabbits under study. This work presents the first in vivo demonstration of remote corneal hydration sensing.

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“…In this plot, the excess reflectivity along the x-axis is generally attributed to the formation of interstitial edema at the burned sites. [30][31][32][33] However, the change in the spectral slope of the THz reflectivity (THz color of the burns), which is shown in the y-axis, is not well understood. One possible explanation suggests that a potential change in the dispersive properties of normal skin as a result of the thermal insult as well as absorption by the water content of the tissue may be responsible for this observation.…”

Section: Density Of Skin Structuresmentioning

confidence: 99%

“…27 Terahertz reflectometry and imaging has recently been proposed for the diagnosis of burn injuries ex vivo [28][29][30] and in vivo. [31][32][33] We have previously shown that the double Debye model, proposed by Pickwell et al, 19 can be extended to explain the higher terahertz reflectivity of moderate burn samples immediately postinjury. 30 In accordance with the general burn literature, 2 an increase in the water content of the burned tissue, due to formation of interstitial edema, has been experimentally observed using THz spectroscopy.…”

Section: Terahertz Modality For Characterization Of Burn Woundsmentioning

confidence: 99%

“…30 In accordance with the general burn literature, 2 an increase in the water content of the burned tissue, due to formation of interstitial edema, has been experimentally observed using THz spectroscopy. [30][31][32][33] Furthermore, we proposed that the sensitivity of THz waves to the postburn reduction in the number and size of discrete normal skin structures, such as microvasculature, sweat glands, and hair follicles can be used as a source of signal contrast in THz burn imaging. 30,33 In this paper, we formulate a hypothesis for a burn diagnosis criterion based on in vivo terahertz reflection spectroscopy results obtained from second-and third-degree burns over a 72-hour period after injury.…”

Section: Terahertz Modality For Characterization Of Burn Woundsmentioning

confidence: 99%

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Terahertz spectroscopy for the assessment of burn injuriesin vivo

et al. 2013

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Abstract. A diagnosis criterion is proposed for noninvasive grading of burn injuries using terahertz radiation. Experimental results are presented from in vivo terahertz time-domain spectroscopy of second-and third-degree wounds, which are obtained in a 72-hour animal study. During this period, the change in the spectroscopic response of the burned tissue is studied. It is shown that terahertz waves are sensitive not only to the postburn formation of interstitial edema, but also to the density of skin structures derived from image processing analysis of histological sections. Based on these preliminary results, it is suggested that the combination of these two effects, as probed by terahertz spectroscopy of the tissue, may ultimately be used to differentiate partial-thickness burns that will naturally heal from those that will require surgical intervention.

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In vivo terahertz imaging of rat skin burns

Cited by 77 publications

References 19 publications

Recent advances in terahertz technology for biomedical applications

Recent advances in terahertz technology for biomedical applications

Assessment of corneal hydration sensing in the terahertz band:in vivoresults at 100 GHz

Terahertz spectroscopy for the assessment of burn injuriesin vivo

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