2015
DOI: 10.1364/ao.54.006448
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In vivo tissue injury mapping using optical coherence tomography based methods

Abstract: An injury causes changes in the optical attenuation coefficient of light beam travelling inside a tissue. We report a method called tissue injury mapping (TIM), which utilizes a non-invasive in vivo optical coherence tomography approach to generate optical attenuation coefficient and microvascular map of the injured tissue. Using TIM, the infarct region development in mouse cerebral cortex during stroke is visualized. Moreover, we demonstrate the changes in human facial skin structure and microvasculature duri… Show more

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Cited by 26 publications
(28 citation statements)
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“…We have recently developed a TIM method by using an algorithm called sorted average intensity projection (sAIP) for en face mapping of the OACs belonging to different tissue types (Baran et al 2015b). The method works by selecting the tissue volume from the 3D OAC data, then sorting the values of OACs in each A-line in ascending order.…”
Section: System and Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…We have recently developed a TIM method by using an algorithm called sorted average intensity projection (sAIP) for en face mapping of the OACs belonging to different tissue types (Baran et al 2015b). The method works by selecting the tissue volume from the 3D OAC data, then sorting the values of OACs in each A-line in ascending order.…”
Section: System and Methodsmentioning
confidence: 99%
“…For OMAG images, we apply sorted maximum intensity projection (sMIP) algorithm (Baran et al 2015b) for each layer of every A-line where the maximum intensity of flow is selected and mapped to an en face plane. We finally apply a Gaussian filter (with 2 x 2 window) to the en face projection maps.…”
Section: System and Methodsmentioning
confidence: 99%
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“…Functional OCT can provide direct measurement of hemodynamic changes caused by stroke in animal models [36, 116, 117]. Both acute and chronic stroke models were investigated in order to gain insights on the injury and brain recovery [36].…”
Section: Oct In Brain Imagingmentioning
confidence: 99%