In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles

Simpson, C.J.S.M.; Salleng, Kenneth J.; Cliffel, David E.; Feldheim, Daniel L.

doi:10.1016/j.nano.2012.06.002

Cited by 183 publications

(156 citation statements)

References 34 publications

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“…GSH is a natural tripeptide containing thiol, amino and carboxylic groups. Simpson et al [20] found that glutathione-coated AuNPs showed low immunogenicity and better biocompatibility. Thus present study also investigated the functionalization of AuNPs with glutathione for subsequent conjugation with GCV.…”

mentioning

confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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Kiroula, et al.: Glutathione-modified Gold Nanoparticles of GanciclovirThis article reports that ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. Citrate-reduced gold nanoparticles were prepared first from chloroauric acid. Further the surface of gold nanoparticles was modified with glutathione. Then ganciclovir was loaded onto the glutathione-modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. Drug loading of 87.27±2.52% was observed for ganciclovir-loaded gold nanoparticles. The particle size distribution of gold nanoparticles ranged from 26.3 to 31 nm. Thus ganciclovir-loaded gold nanoparticles were successfully prepared, which might further improve the oral bioavailability of ganciclovir.

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confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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“…In order to record the complete blood counts, 41,42 healthy BALB/c mice were intravenously injected with 200 μL FARIPNPs at a dose of 15 mg/kg. Saline-treated mice (200 μL) were used as the control group.…”

Section: Histology and Blood Examinationmentioning

confidence: 99%

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Xin

Yang

2016

IJN

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“…The size of gold nanoparticles is usually over 10 nm of diameter. Even though they have shown great prospective in cancer diagnosis and therapy, their safety remains being worried for their accumulation forming largesize particles in liver and spleen and thus inducing the difficulty of metabolism or excreation [27]. Ideal nanomaterials should have little accumulation in organs, be cleared out of the body effectively and show minimum interference with other diagnostic tests [28].…”

Section: Introductionmentioning

confidence: 99%

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

Liu¹,

Li²,

Wu³

et al. 2017

Nano BioMed ENG

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The gold nanoclusters (Au-NCs) have emerged for delivery of various payloads such as small molecular drug and big molecular proteins due to their low immunogenicity, quick clearance and good biocompatibility. Even though they have shown great prospective in biomedical area, there are also some security problems which should be investigated further more. BRCAA1 mAb Au-NCs is a probe for gastric cancer diagnosis prepared by conjugating BRCAA1 monoclonal antibody with fluorescent Au-NCs. In this research, the renal excretion and effect on glomerulus filtration of BRCAA1 mAb AuNCs in rats were investigated. The result indicated that BRCAA1 mAb Au-NCs could be eliminated through the glomerulus filtration as early as 2 hr after the administration following the excretion of other proteins in the plasma such as immunoglobulin. Electron microscope image and pathological analysis of kidney showed that BRCAA1 mAb Au-NCs induced some structural injury such as capillaries endotheliocyte damage, pycnosis, karyorrhexis and hyalomitome acidophilia enhancement. Biochemical indexes including ALT, AST, BUN, TBIL, CK and CREA are abnormal in the period of 2 to 48 hr after the administration. The results of Western blotting and immunohistochemisty show the downregulation of three key proteins (ZO-1, Nephrin and Podocin) indicating the influence of BRCAA1 mAb Au-NCs on the foot processes of glomerular epithelial cells and shallow intercellular junctions or slit diaphragms.

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In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles

Cited by 183 publications

References 34 publications

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

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