Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula, Neha; Negi, Jeetendra Singh

doi:10.4172/pharmaceutical-sciences.1000120

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…All the peaks characterizing flavonoids were observed. These results were in good agreement with those of Kiroula et al (2016) and Sulaiman et al (2020) [ 26 , 27 ].…”

Section: Resultssupporting

confidence: 93%

Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria—Evidence from In Silico-Supported In Vitro Studies

et al. 2021

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Flavonoids are a class of bioactive plant-derived natural products that exhibit a broad range of biological activities, including antibacterial ones. Their inhibitory activity toward Gram-positive bacterial was found to be superior to that against Gram-negative ones. In the present study, a number of flavonoid-coated gold nanoparticles (GNPs) were designed to enhance the antibacterial effects of chrysin, kaempferol, and quercetin against a number of Gram-negative bacteria. The prepared GNPs were able to conjugate to these three flavonoids with conjugation efficiency ranging from 41% to 80%. Additionally, they were able to exert an enhanced antibacterial activity in comparison with the free flavonoids and the unconjugated GNPs. Quercetin-coated GNPs were the most active nano-conjugates and were able to penetrate the cell wall of E. coli. A number of in silico experiments were carried out to explain the conjugation efficiency and the antibacterial mechanisms of these flavonoids as follows: (i) these flavonoids can efficiently bind to the glutathione linker on the surface of GNPs via H-bonding; (ii) these flavonoids, particularly quercetin, were able to increase the bacterial membrane rigidity, and hence decrease its functionality; (iii) these flavonoids can inhibit E. coli’s DNA gyrase (Gyr-B) with IC50 values ranging from 0.9 to 3.9 µM. In conclusion, these bioactive flavonoid-based GNPs are considered to be very promising antibiotic candidates for further development and evaluation.

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“…All the peaks characterizing flavonoids were observed. These results were in good agreement with those of Kiroula et al (2016) and Sulaiman et al (2020) [ 26 , 27 ].…”

Section: Resultssupporting

confidence: 93%

Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria—Evidence from In Silico-Supported In Vitro Studies

et al. 2021

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“…GSSG Synthesis of AuNPs via citrate reduction of AuCl3 was proven successful as UV-vis spectroscopy revealed maximum absorbance (Absmax) in the UV-vis spectrum (Figure 1) occurred at wavelength 518 nm. Absmax achieved aligned with previous findings that showed SPR properties of AuNPs can be observed in the range of 500 -600 nm [1], [3], [5], [21]- [23].…”

Section: A Characterization Of Synthesized Aunps and Aunp-supporting

confidence: 89%

Assessment of Disulfide-linked Gold Nanoparticles as Colorimetric Sensor for Human Chorionic Gonadotropin Detection

Yusri¹,

Hassan²,

Azhari³

2020

MJoSHT

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Gold nanoparticles (AuNPs) are a highly versatile compound to be used in sensing components due to their unique physicochemical and optical properties. Due to its flexibility for surface conjugation, glutathione disulfide-linked gold nanoparticle (AuNP-GSSG) was produced in this study to assess its sensing performance as a colorimetric sensor for human chorionic gonadotropin (HCG). Spectroscopic characterization of AuNP-GSSG confirmed the conjugation of GSSG onto the surface of AuNPs. AuNP-GSSG also showed high sensory performance with good linearity and low detection limit. However, due to the high percentage of interference, usage of AuNP-GSSG as an HCG sensor requires further pre-treatment step to reduce the interference and increase the sensor accuracy.

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“…Moreover, the peak at 1391 cm -1 indicated the intensity of C-OH deformation vibration, which likely arose from surface-bound sodium citrate. In short, the results showed that the sodium citrate moieties are attached to the surface of rGO and act as a capping agent which stabilizes the rGO [23].…”

Section: Resultsmentioning

confidence: 97%

Reduced Graphene Oxide/Gold Nanoparticles Modified Screen‐Printed Electrode for the Determination of Palmitic Acid

2021

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Palm oil is one of the major oils and fats produced in the world today. The quality of palm oil is crucial to be investigated, and one of the quality indices is free fatty acid (FFA) content. Therefore, in this study, an electrochemical approach for the determination of FFA has been explored as an alternative to replace the conventional method (titration method). The electrochemical method was developed based on electrochemically reduced graphene oxide (rGO) coupled with gold nanoparticles (AuNPs) deposited onto a screen-printed carbon electrode (SPCE) via drop-casting technique. The voltammetric behaviour of 2-methyl-1,4-naphthoquinone (VK3) in the presence of palmitic acid at the modified electrode was investigated in an acetonitrile/water mixture containing lithium perchlorate (LiClO4). The electrochemical detection of palmitic acid was based on the voltammetric reduction of VK3 to form the corresponding hydroquinone which is proportional to the concentration of palmitic acid. Under optimum conditions, the developed method showed a good linear relationship towards palmitic acid in the concentration ranging from 0.192 mM to 0.833 mM with the detection limit of 0.015 mM. The exploration of the developed system is expected to achieve high sensitivity and excellent selectivity towards the determination of FFA content in palm oil.

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Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Cited by 11 publications

References 31 publications

Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria—Evidence from In Silico-Supported In Vitro Studies

Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria—Evidence from In Silico-Supported In Vitro Studies

Assessment of Disulfide-linked Gold Nanoparticles as Colorimetric Sensor for Human Chorionic Gonadotropin Detection

Reduced Graphene Oxide/Gold Nanoparticles Modified Screen‐Printed Electrode for the Determination of Palmitic Acid

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