1975
DOI: 10.1530/acta.0.0790394
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In VIVO UPTAKE AND METABOLISM OF 3h-5α-Androstane-3α, 17β-Diol AND OF 3h-5α-Androstane-3β,17β-Diol BY HUMAN PROSTATIC HYPERTROPHY

Abstract: Tritiated 5\g=a\-androstane-3\g=a\,17\g=b\-diol(3\g=a\-diol) and 5\g=a\-androstane-3\g=b\,17\g=b\\x=req-\ diol (3\g=b\-diol)respectively were administered to patients with benign prostatic hypertrophy (bph) undergoing prostatectomy. In prostate and skeletal muscle homogenates and in plasma the total radioactivity content

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Cited by 23 publications
(12 citation statements)
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“…In vivo, the formation of 3␤-Diol is virtually irreversible, whereas 3␣-Diol can be converted back to DHT via 3␣-hydroxysteroid oxidase activity (13)(14)(15)(16)(17). Reformation of DHT from 3␤-Diol is prevented, because 3␤-Diol is either irreversibly hydroxylated at the C-6 and/or C-7 position or is oxidized to (epi)androsterone (13)(14)(15)(16)(17)(18)(19)(20). 3␣-Diol and 3␤-Diol, once formed, are also glucuronidated and sulfated, leading to elimination of the androstanes into the circulation and their final excretion (21,22).…”
mentioning
confidence: 99%
“…In vivo, the formation of 3␤-Diol is virtually irreversible, whereas 3␣-Diol can be converted back to DHT via 3␣-hydroxysteroid oxidase activity (13)(14)(15)(16)(17). Reformation of DHT from 3␤-Diol is prevented, because 3␤-Diol is either irreversibly hydroxylated at the C-6 and/or C-7 position or is oxidized to (epi)androsterone (13)(14)(15)(16)(17)(18)(19)(20). 3␣-Diol and 3␤-Diol, once formed, are also glucuronidated and sulfated, leading to elimination of the androstanes into the circulation and their final excretion (21,22).…”
mentioning
confidence: 99%
“…Oxidative 3␣-HSD activity, which converts 3␣-diol to 5␣-DHT, has been reported in human prostatic hypertrophy (9) and in the ventral prostate of castrated rats (10). 3␣-Diol stimulated prostate growth in castrated dogs (11,12) and induced virilization of the urogenital tract both in the fetal rat and in the fetus found in the pouch of the female wallaby (13,14).…”
mentioning
confidence: 99%
“…Studies in the rat, dog, marsupial and human also indicate that circulating 3α-diol can be oxidized back to 5α-DHT (Orlowski et al, 1983;Walsh and Wilson, 1976;DeKlerk et al, 1979;Jacobi et al, 1977; Liehy et al, 2001;Shaw et al, 2000;). In fact 50% of an administered dose of 3α-diol in humans was converted to 5α-DHT within the prostate, indicating that the back conversion is significant in androgen action (Horst et al, 1975;Kinouchi and Horton 1974). Backdoor pathways to 5α-DHT using 3α-diol as a precursor have been proposed in which the production of DHT "by-passes" the formation of Δ 4 -androstene-3,17-dione and testosterone, (Auchus, 2004).…”
Section: Androgen Biosynthesis and Metabolism In The Prostatementioning
confidence: 99%