In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

Abstract

An agent for actinide sequestration with fast uranium uptake kinetics and efficient in vivo uranium removal using a nanoscale metal-organic framework (nano-MOF) is proposed. UiO-66 nanoparticles post-synthetically functionalized with carboxyl groups, UiO-66-(COOH) 4 -180, exhibit the fastest uranium uptake kinetics reported with more than 65 % of uranyl in fetal bovine serum (FBS) removed within 5 min. Moreover, the in vivo bio-distribution studies show that the material partially accumulates in kidneys and femurs where uranium mainly deposits facilitating the in vivo sequestration of uranium. The results of the in vivo uranium decorporation assays with mice show that UiO-66-(COOH) 4 -180 could successfully reduce the amounts of uranyl deposited in kidneys and femurs by up to 55.4 % and 36.5 %, respectively, and is significantly more efficient than the commercial actinide decorporation agent, ZnNa 3 -DTPA.

Improving in vivo Uranyl Removal Efficacy of a Nano‐Metal Organic Framework by Interior Functionalization with 3‐Hydroxy‐2‐pyridinone

“…[ 7 ] In comparison, the HOPO functionalized nano‐MOF materials exhibit higher decorporation performance in prophylactic administration than 3,2‐HOPO‐COOH ligand, which could possibly be attributed to the accumulation of nMOFs in kidneys similar to the UiO‐66‐COOH nano agents. [ 12,49 ] The results of in vivo decorporation experiment demonstrate the interior functionalization is an effective strategy to improve the actinide sequestration ability of nano porous materials. It is noteworthy that the decorporation ratio of MIL‐101‐HOPO is not as high as that of UiO‐66‐COOH, despite its larger pore size.…”

“…[ 22‐23 ] Thereafter, we synthesized a carboxyl‐functionalized nMOFs (UiO‐66‐(COOH) 4 ‐ 180), in which carboxyl groups are pre‐organized in the pores to improve the selectivity and binding ability of uranyl. [ 12 ] As a result, UiO‐66‐(COOH) 4 ‐180 exhibits a uranyl sequestration ratio that is three times higher than that of the pentacarboxylate ligand ZnNa 3 ‐DTPA in vivo . The CON‐AO obtained via the attachment of AO groups to the channels of covalent organic sheets also exhibits elevated decorporation efficacy of uranyl than DTPA ligands.…”

“…To overcome the disadvantages of fast excretion, relative high toxicity, and poor uranium decorporation efficacy of molecular agents, functionalized nanomaterials, such as nano‐metal organic frameworks, [ 12 ] chitosan nanoparticles, [ 13 ] melanin nanoparticles, [ 14 ] and covalent organic nanosheets, [ 15 ] have been reported by our group. The exterior functionalization of ligands would diminish the removal efficacy of uranyl or ROS as observed in the cases of chitosan nanoparticles decorated with HOPO ligands on the surface (COS‐HOPO) and melanin nanoparticles with attached PEG (MNPs‐PEG).…”

Novel Phytic Acid-Based Supramolecular Material for Uranium Removal from Highly Acidic Media: Synthesis, Performance, and Mechanistic Insights

“…4 Therefore, it is critical to efficiently remove and separate U(VI) from nuclear wastewater. To date, various adsorption materials have been developed for U(VI) adsorption research, including carbon materials, 5,6 metal oxide, 7,8 silicon-based materials, 9 polymers, 10,11 metal−organic frameworks (MOFs), 12,13 and covalent organic frameworks. 14,15 Among these adsorbents, supramolecular self-assembly material (SSMs) become intriguing in uranium removal and separation from radioactive wastewater due to their simple route, various structural frameworks, tailoring properties, and performance.…”

Decorporation of uranyl in kidneys using an engineered nanocomposite

“…16 Using nanochelating agents for decorporation therapy is an ever-developing strategy for the treatment of internal uranium contamination. [17][18][19][20] An inspiration of kidneytargeted chitosan oligosaccharide (COS) nanoparticles may cater exactly to the targeted removal of uranium in the kidneys. 21 Moreover, the modification of HOPO ligands with high affinity and low toxicity on the surface of COS nanoparticles remedies the lack of specific functional groups for uranyl sequestration of COS.…”