In vivo wound healing performance of drug loaded electrospun composite nanofibers transdermal patch

Kataria, Karun; Gupta, Ashish; Rath, Goutam; Mathur, R.B.; Dhakate, Sanjay R.

doi:10.1016/j.ijpharm.2014.04.047

Cited by 298 publications

(146 citation statements)

References 29 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…This is due to the slow dissolution of the polymer through layer by layer over a time due to erosion. Earlier study also supports the possibility of polymer erosion [49].…”

Section: Swelling Indexsupporting

confidence: 74%

“…The degree of swelling of PVA-CS patches in PBS pH 7.4 was 109.2 AE 3.96, 120 AE 5.5%, 150 AE 4.3%, 178.56 AE 4.68, 201.20 AE 5.2%, 183 AE 2.7, and 160 AE 3% for the time intervals of 1, 2, 4, 6, 8, 10, and 12 h, respectively. In the case of drug-loaded PVA-CS patches, the degree of swelling decreased due to the water-soluble sulfanilamide can interacts with the polymeric chain through hydrogen bonded crosslinks that restricting further entry of water to swell [37,49]. However, after maximum swelling at 8 h, further increases in time show a decrease in the degree of swelling in all cases.…”

Section: Swelling Indexmentioning

confidence: 99%

See 1 more Smart Citation

Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

Ganesh

Abidov

Ubaidulla³

et al. 2016

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

“…This is due to the slow dissolution of the polymer through layer by layer over a time due to erosion. Earlier study also supports the possibility of polymer erosion [49].…”

Section: Swelling Indexsupporting

confidence: 74%

Section: Swelling Indexmentioning

confidence: 99%

Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

Ganesh

Abidov

Ubaidulla³

et al. 2016

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

“…Previous work has shown that antibioticloaded collagen scaffolds, 47 composite fibers comprised of polyglyconate and porous poly(DLlactic-co-glycolic acid) (PDLGA), 48,49 and electrospun nanofibers consisting of biodegradable poly vinyl alcohol and sodium alginate, 50 can reduce infection either in vitro or in vivo. Recently, Albaugh et al combined topical antibiotics with cellulose dressing to fight infection of lower extremity chronic ulcers infected with MRSA.…”

Section: Discussionmentioning

confidence: 99%

Ciprofloxacin-Loaded Keratin Hydrogels PreventPseudomonas aeruginosaInfection and Support Healing in a Porcine Full-Thickness Excisional Wound

Roy

Tomblyn

Burmeister

et al. 2015

Advances in Wound Care

View full text Add to dashboard Cite

Objective: Cutaneous wound infection can lead to impaired healing, multiple surgical procedures, and increased hospitalization time. We tested the effectiveness of keratin-based hydrogels (termed ''keratose'') loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa. Approach: Using a porcine excisional wound model, 10 mm full-thickness wounds were inoculated with 10 6 colony-forming units of P. aeruginosa and treated on days 1 and 3 postinoculation with ciprofloxacin-loaded keratose hydrogels. Bacteria enumeration and wound healing were assessed on days 3, 7, and 11 postinjury. Results: Ciprofloxacin-loaded keratose hydrogels reduced the amount of P. aeruginosa in the wound bed by 99.9% compared with untreated wounds on days 3, 7, and 11 postinjury. Ciprofloxacin-loaded keratose hydrogels displayed decreased wound contraction and reepithelialization at day 7 postinjury. By day 11, wounds treated with ciprofloxacin-keratose hydrogels contained collagen-rich granulation tissue and myofibroblasts. Wounds treated with ciprofloxacin-loaded keratose hydrogels exhibited a transient increase in macrophages in the wound bed at day 7 postinjury that subsided by day 11. Innovation: Current therapies for wound infection include systemic antibiotics, which could lead to antibiotic resistance, and topical antimicrobial treatments, which require multiple applications and can delay healing. Here, we show that ciprofloxacin-loaded keratose hydrogels inhibit cutaneous wound infection without interfering with key aspects of the healing process including granulation tissue deposition and remodeling. Conclusions: Ciprofloxacin-loaded keratose hydrogels have the potential to serve as a point-of-injury antibiotic therapy that prevents infection and supports healing following cutaneous injury.

show abstract

“…Experiments were run in triplicate. Drug content was calculated according to the following equation [37]. …”

Section: Drug Loading Capacitymentioning

confidence: 99%

Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

Nazari

Kontogiannidou

Ahmad

et al. 2017

European Polymer Journal

View full text Add to dashboard Cite

Polymer based dosages form the mainstay of drug delivery systems either as simple matrix carrier materials or active release behaviour modulating agents. In addition, several techniques have been developed further to deliver novel polymeric structures. One such method is electrospinning (ES); a maturing process which is operational at the ambient environment and enables drug loading (in molecularly dispersed form) directly into a fibrous polymer matrix system. Since there is an impending need to address healthcare challenges arising from an increase in the aging population (requiring enhanced treatments), the ES method was used to develop fibrous polymer composite-indomethacin (

show abstract

In vivo wound healing performance of drug loaded electrospun composite nanofibers transdermal patch

Cited by 298 publications

References 29 publications

Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

Ciprofloxacin-Loaded Keratin Hydrogels PreventPseudomonas aeruginosaInfection and Support Healing in a Porcine Full-Thickness Excisional Wound

Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

Contact Info

Product

Resources

About