Inactivation and Disinfection of Zika Virus on a Nonporous Surface

Wilde, Cameron; Chen, Zheng; Kapes, Tanya; Chiossone, Cory; Lukula, Salimatu; Suchmann, Donna B; Nims, Raymond W.; Zhou, Sifang

doi:10.4172/1948-5948.1000319

Cited by 7 publications

(15 citation statements)

References 12 publications

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“…The impact of high organic load on viral inactivation efficacy has been described previously for Zika virus and West Nile virus (two members of the flavivirus family) [14]. In the studies of Zika virus inactivation, a 90% sheep blood matrix present at the time of virus deposition onto the carriers afforded protection of the virus against the inactivating effects of heat, sodium hypochlorite, and peracetic acid.…”

Section: Discussionmentioning

confidence: 92%

“…In the studies of Zika virus inactivation, a 90% sheep blood matrix present at the time of virus deposition onto the carriers afforded protection of the virus against the inactivating effects of heat, sodium hypochlorite, and peracetic acid. Time kinetics were not investigated in the studies, and it was hypothesized that the organic load might confer protection to the virus in two ways: 1) through stabilization of the ZIKV through protein binding, maintaining viral particle organization on the environmental surface, changing the distribution and layout of virus on the surface, or forming a protective layer on top of the virus particles; or 2) reaction of the organic material with the active ingredients of the disinfectants to reduce their effective concentrations [14].…”

Section: Discussionmentioning

confidence: 99%

“…Efficacy testing for disinfectants to be used for these applications is best performed in carrier studies, rather than in solution studies. The former more appropriately measure efficacy for inactivation of viruses deposited on surfaces [11][12][13][14]. In addition, the presence of organic load at the time of deposition of the virus can be investigated to realistically model the contamination of a surface by a virus suspended in blood or other organic matrices (urine, sputum, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the presence of organic load at the time of deposition of the virus can be investigated to realistically model the contamination of a surface by a virus suspended in blood or other organic matrices (urine, sputum, etc.) [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Lukula¹,

Chiossone²,

Fanuel³

et al. 2017

J Microb Biochem Technol

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Lukula¹,

Chiossone²,

Fanuel³

et al. 2017

J Microb Biochem Technol

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“…Such studies are appropriate when evaluating the effectiveness of inactivation processes aimed at virus infectivity reduction in solutions (e.g., pasteurization). When the susceptibility of viruses deposited on a surface to heating is to be evaluated, such studies are most appropriately performed using carriers (Scheme 1) [5,6]. A known amount of virus is applied to the carriers (small representative pieces of a given material type) and allowed to dry in the absence or presence of a matrix (such as blood, saline, or culture medium).…”

Section: Introductionmentioning

confidence: 99%

Carrier and Liquid Heat Inactivation of Poliovirus and Adenovirus

Zhou¹,

Wilde²,

Chen³

et al. 2018

Disinfection

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Viral inactivation is typically studied using virus suspended in liquid (liquid inactivation) or virus deposited on surfaces (carrier inactivation). Carrier inactivation more closely mimics disinfection of virus contaminating a surface, while liquid inactivation mimics virus inactivation in process solutions. The prevailing opinion has been that viruses are more susceptible to heat inactivation when suspended in liquid than when deposited on surfaces. In part, this reflects a paucity of comparative studies performed in a side-by-side manner. In the present study, we investigated the relative susceptibilities of the enteroviruses poliovirus-1 and adenovirus type 5 to heat inactivation in liquid versus carrier studies. The results of our side-by-side studies suggest that these two viruses are more readily inactivated when heat is applied to virus deposited on carriers. Decimal reduction values (i.e., the amount of time required to reduce the virus titer by one log 10) measured at 46°C displayed the greatest difference between carrier and liquid inactivation approaches, with values ranging from 14.0 to 15.2 min (carrier) and from 47.4 to 64.1 min (liquid) for poliovirus. The corresponding values for adenovirus 5 were 18.2-29.2 min (carrier) and 20.8-38.3 min (liquid). At 65°C, the decimal reduction values were more similar (from 4 to 6 min) for the various inactivation approaches.

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A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major sources of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.

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Inactivation and Disinfection of Zika Virus on a Nonporous Surface

Cited by 7 publications

References 12 publications

Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Carrier and Liquid Heat Inactivation of Poliovirus and Adenovirus

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

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