Inactivation of avian influenza virus H1N1 by photocatalyst under visible light irradiation

Takehara, Kazuhiko; Yamazaki, Kumiko; Miyazaki, M; Yamada, Yuichi; Ruenphet, Sakchai; Jahangir, Alam; Shoham, Dany; Okamura, Masahi; Nakamura, Masayuki

doi:10.1016/j.virusres.2010.03.006

Cited by 47 publications

(32 citation statements)

References 7 publications

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“…There are numerous reports on virus inactivation by the photocatalytic properties of TiO 2 , which also generates ·OH by the oxidation of H 2 O (7,12,13,21). On the other hand, Cu ϩ probably participates in a Fenton-like reaction to produce ·OH from hydrogen peroxide (16) Similarly, Cu ϩ dissolved from CuI in water or Cu ϩ existing on the surface of CuI may be oxidized back to Cu 2ϩ with the subsequent formation of hydrogen peroxide via the superoxide intermediate.…”

Section: Discussionmentioning

confidence: 99%

Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus

Fujimori¹,

Sato²,

Hayata³

et al. 2012

Appl Environ Microbiol

202

203

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We investigated the antiviral activity of nanosized copper(I) iodide (CuI) particles having an average size of 160 nm. CuI particles showed aqueous stability and generated hydroxyl radicals, which were probably derived from monovalent copper (Cu ؉ ). We confirmed that CuI particles showed antiviral activity against an influenza A virus of swine origin (pandemic [H1N1] 2009) by plaque titration assay. The virus titer decreased in a dose-dependent manner upon incubation with CuI particles, with the 50% effective concentration being approximately 17 g/ml after exposure for 60 min. SDS-PAGE analysis confirmed the inactivation of the virus due to the degradation of viral proteins such as hemagglutinin and neuraminidase by CuI. Electron spin resonance (ESR) spectroscopy revealed that CuI generates hydroxyl radicals in aqueous solution, and radical production was found to be blocked by the radical scavenger N-acetylcysteine. Taken together, these findings indicate that CuI particles exert antiviral activity by generating hydroxyl radicals. Thus, CuI may be a useful material for protecting against viral attacks and may be suitable for applications such as filters, face masks, protective clothing, and kitchen cloths.

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Section: Discussionmentioning

confidence: 99%

Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus

Fujimori¹,

Sato²,

Hayata³

et al. 2012

Appl Environ Microbiol

202

203

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“…; Takehara et al . ; Banerjee et al . ), because the damaging effects of ROS are not specific towards any given strain.…”

Section: Introductionmentioning

confidence: 99%

“…Photodynamic therapy using porphyrins has been shown to be highly effective against a number of bacterial strains (Malik et al 1990;Stojiljkovic et al 2001;Banfi et al 2006;Yu et al 2009;Banerjee et al 2010) and viruses (Malik et al 1994;Casteel et al 2004;Wen et al 2009;Takehara et al 2010;Banerjee et al 2012). Porphyrins act by producing reactive oxygen species (ROS) that act on multiple targets in the pathogen; consequently, it is less likely that pathogens will develop resistance.…”

Section: Introductionmentioning

confidence: 99%

Light-activated porphyrin-based formulations to inactivate bacterial spores

et al. 2012

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Aim: The objective of this study was to develop porphyrin-based formulations to inactivate Bacillus spores. We probed the effect of porphyrins alone and in combination with germinants against both Bacillus cereus and Bacillus anthracis spores in the presence of light.Methods and Results: We tested the effect of two different porphyrins, aminemodified protoporphyrin IX (PPIX) and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP). Treatment with the porphyrins alone did not significantly influence spore viability. However, when spores were pretreated with a solution containing the germinants, L-alanine and inosine, the spore viability dropped by as much as 4Á5 logs in the presence of light. The extent of inactivation depended on the germination conditions and the type of porphyrin used, with TMP being more effective. Conclusion: Porphyrins can be used effectively in combination with germinants to inactivate Bacillus spores. Significance and Impact of the Study: The results of this study provide evidence that porphyrins can be used to inactivate Bacillus spores in the presence of germinants and light irradiation. This finding may be general and may be extended to spores of other pathogens.

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“…A novel photocatalyst, iLUMiO, developed by Sumitomo Chemical Co., Ltd. (Tokyo, Japan) is a platinum-supported tungsten oxide (Pt-WO 3 ). It has already been reported to have inactivation activity towards avian influenza virus (AIV) under visible light conditions without UV radiation [21].…”

mentioning

confidence: 99%

“…Sang et al [16] reported that TiO 2 could inactivate non-enveloped viruses, including rotavirus, astrovirus and calicivirus with visible light irradiation after exposure for 24 hr. We have already demonstrated that the novel photocatalyst based on platinum-loaded tungsten oxide (Pt-WO 3 ), named iLUMiO, coated on glass plates showed antiviral activity against AIV H1N1 under visible light within 2 hr [21].…”

mentioning

confidence: 99%

Inactivation of Goose Parvovirus, Avian Influenza Virus and Phage by Photocatalyst on Polyethylen Terephthalate Film under Light Emitting Diode (LED)

Hasegawa

Tamura

Satoh

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. The inactivation effect of a novel photocatalyst on polyethylene terephthalate film on goose parvovirus (GPV), avian influenza virus (AIV) and Qβ phage was evaluated. Under a light emitting diode (LED) light (range 410-750 nm), GPV was inactivated by irradiation at 1,000 lux for 6 hr, while AIV and Qβ phage were inactivated by irradiation at 150 lux for 2 hr. These data suggest that this new photocatalyst can potentially be used as one of the materials to inactivate viruses in the indoor environment and help us to prevent viral infectious diseases through indirect contact.

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Inactivation of avian influenza virus H1N1 by photocatalyst under visible light irradiation

Cited by 47 publications

References 7 publications

Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus

Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus

Light-activated porphyrin-based formulations to inactivate bacterial spores

Inactivation of Goose Parvovirus, Avian Influenza Virus and Phage by Photocatalyst on Polyethylen Terephthalate Film under Light Emitting Diode (LED)

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