Inactivation of chlorhexidine gluconate on skin by incompatible alcohol hand sanitizing gels

Kaiser, Nancy; Klein, Dan; Karanja, Peter; Greten, Z.; Newman, Jerry

doi:10.1016/j.ajic.2008.12.008

Cited by 32 publications

(27 citation statements)

References 10 publications

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“…previously treated with sanitizing products, then artificially contaminated with challenge microorganisms to test residual activity of tested products after use (9,28,35,54). In vivo studies involved experiments carried out with selected human volunteers to estimate the efficacy of each tested product to remove or inactivate target microorganisms from artificially contaminated whole hands, finger pads or gloves.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Instant Hand Sanitizers against Foodborne Pathogens Compared with Hand Washing with Soap and Water in Food Preparation Settings: A Systematic Review

Foddai

Grant

Dean

2016

Journal of Food Protection

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Section: Resultsmentioning

confidence: 99%

“…Finally, a new generation of alcohol-free lotions is attracting more and more interest (1,28,35). Evidence from in vitro and ex vivo studies showed similar efficacy against target bacteria compared to alcohol-based products, with prolonged activity after application, and potentially less skin irritation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Instant Hand Sanitizers against Foodborne Pathogens Compared with Hand Washing with Soap and Water in Food Preparation Settings: A Systematic Review

Foddai

Grant

Dean

2016

Journal of Food Protection

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“…Thus, clearance of CHX from monomers may have occurred. Detergents (42) and non-ionic chemical cleaners are known to deactivate CHX (43).…”

Section: Discussionmentioning

confidence: 99%

Effect of dentin etching and chlorhexidine application on metalloproteinase‐mediated collagen degradation

Osorio

Yamauti

Osorio

et al. 2011

European J Oral Sciences

154

137

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Dentin matrix metalloproteinases (MMPs) are involved in collagen degradation of resin-dentin interfaces. This study evaluated if collagen degradation can be prevented by chlorhexidine after different dentin demineralization procedures. Human dentin demineralization was performed with phosphoric acid (PA), EDTA, or acidic monomers (ClearfilSEBond and XENOV). Specimens were stored (24 h, 1 wk or 3 wk) in the presence or absence of chlorhexidine. In half of the groups, active MMP-2 was incorporated into the storing solution. C-terminal telopeptide determination (ICTP) was performed in the supernatants. Collagen degradation was higher in PA and EDTA-demineralized dentin. Chlorhexidine reduced collagen degradation in these groups only for 24 h. When dentin was demineralized with SEBond or Xeno, collagen degradation was reduced up to 30%, but addition of exogenous MMP-2 significantly increased collagen degradation. In self-etchant treated dentin the inhibitory effect of chlorhexidine on MMPs lasted up to 3 wk. Treating dentin with EDTA, PA or self-etching agents produces enough demineralization to permit cleavage of the exposed collagen. Monomers infiltration may exert protection on demineralized collagen, probably through immobilization of MMPs. The partial inhibitory action of CHX on MMP activity produced by self-etching adhesives was prolonged compared to the short-acting in PA or EDTA-treated dentin.

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“…After screening the titles and/or abstracts, we excluded 209 articles and hence 22 eligible articles remained. After the final screening, only three articles addressed the dermatologic usage of topical CHG and its incompatibility, specifically addressing the following compounds: carbomer [6] , triethanolamine [7,8] , and acrylates/C10-C30 alkyl acrylate crosspolymer [6,7] . Figure 1 showed a flow diagram outlining the selection of articles.…”

Section: Resultsmentioning

confidence: 99%

Evidence of incompatibility for topical anionic agents used in conjunc-tion with chlorhexidine gluconate: A systematic review

Tran¹,

Huynh²,

Bruins³

et al. 2016

J Surg Dermatol

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<p>Chlorhexidine gluconate (CHG) is a widely used antiseptic agent for skin and wound disinfection. The cationic properties of CHG may allow its inactivation and precipitation by anionic agents in commonly used topical agents. We conducted a systematic review by searching through PubMed, Cochrane Library, and Web of Science databases and selected original research articles reporting on CHG incompatibility, defined as inactivation or precipitation. The search yielded 22 publications that demonstrated CHG incompatibility via: 1) reduced antibacterial activity (carbomer, acrylates/C10-C30 alkyl acrylate crosspolymer, dentin, bovine serum albumin, copolymer M239144, sodium lauryl sulfate, heat-killed microbes, triethanolamine, and bark cork); and 2) visible precipitate formation (sodium hypochlorite, EDTA, saline, ethanol, andnystatin). Only three publications reported on CHG incompatibility in dermatology, specifically for carbomer, triethanolamine, and acrylates/C10-C30 alkyl acrylate crosspolymer. Although limited evidence linking CHG incompatibility and anionic agents exists, clinicians should carefully consider the nature of topical agents used if CHG is concurrently applied. Increased awareness of CHG incompatibility may result in better antibacterial activity thus ensuring optimal patient management.</p>

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Inactivation of chlorhexidine gluconate on skin by incompatible alcohol hand sanitizing gels

Cited by 32 publications

References 10 publications

Efficacy of Instant Hand Sanitizers against Foodborne Pathogens Compared with Hand Washing with Soap and Water in Food Preparation Settings: A Systematic Review

Efficacy of Instant Hand Sanitizers against Foodborne Pathogens Compared with Hand Washing with Soap and Water in Food Preparation Settings: A Systematic Review

Effect of dentin etching and chlorhexidine application on metalloproteinase‐mediated collagen degradation

Evidence of incompatibility for topical anionic agents used in conjunc-tion with chlorhexidine gluconate: A systematic review

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