Inactivation of replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on common surfaces by disinfectants

Pope, Zachary; Weisend, Carla; Shah, Aditya; Ebihara, Hideki; Rizza, Stacey A.

doi:10.1017/ice.2021.527

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…152 In commercial products, it is not uncommon to see ethanol or propanol combined with other potentially effective agents such as surfactants or quaternary ammonium compounds. 81,82,142,161,167,169 It is proposed that a concomitant surfactant may enhance efficacy. 161…”

Section: Alcoholsmentioning

confidence: 99%

“…158 In fact, they may be better combined with other agents. 81,82,142 Commercial solutions or other products not uncommonly include a combination of more than one quaternary ammonium agent or a combination of quaternary ammonium agents with other surfactants. 1,81,83,142,167 Several products listing surfactants only, such as some soaps or washing liquids, have efficacy, and the latter may complicate the understanding of active ingredients when products are being assessed.…”

Section: Detergents and Surfactantsmentioning

confidence: 99%

“…81,82,142 Commercial solutions or other products not uncommonly include a combination of more than one quaternary ammonium agent or a combination of quaternary ammonium agents with other surfactants. 1,81,83,142,167 Several products listing surfactants only, such as some soaps or washing liquids, have efficacy, and the latter may complicate the understanding of active ingredients when products are being assessed. 1,49,77,82,83,161 Some studies list a single active agent when indeed a product may have several chemicals that have potential antiviral effects.…”

Section: Detergents and Surfactantsmentioning

confidence: 99%

“…Building on the success of oxygen radicals in inactivating coronaviruses, several studies have assessed either hydrogen peroxide or ozonation. 1 , 127 , 142 Exposure to vaporized hydrogen peroxide under variable conditions leads to marked reduction of both inactive and cultivable viruses. 25 , 143 , 144 , 145 Time for complete inactivation can be prolonged depending on the circumstances.…”

Section: Peroxides and Ozonationmentioning

confidence: 99%

Section: Detergents and Surfactantsmentioning

confidence: 99%

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Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Cimolai

2022

Journal of Medical Virology

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Given the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as witnessed early in the coronavirus disease 2019 (COVID‐19) pandemic, concerns arose with the existing methods for virus disinfection and decontamination. The need for SARS‐CoV‐2‐specific data stimulated considerable research in this regard. Overall, SARS‐CoV‐2 is practically and equally susceptible to approaches for disinfection and decontamination that have been previously found for other human or animal coronaviruses. The latter have included techniques utilizing temperature modulation, pH extremes, irradiation, and chemical treatments. These physicochemical methods are a necessary adjunct to other prevention strategies, given the environmental and patient surface ubiquity of the virus. Classic studies of disinfection have also allowed for extrapolation to the eradication of the virus on human mucosal surfaces by some chemical means. Despite considerable laboratory study, practical field assessments are generally lacking and need to be encouraged to confirm the correlation of interventions with viral eradication and infection prevention. Transparency in the constitution and use of any method or chemical is also essential to furthering practical applications.

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Section: Alcoholsmentioning

confidence: 99%

Section: Detergents and Surfactantsmentioning

confidence: 99%

Section: Detergents and Surfactantsmentioning

confidence: 99%

Section: Peroxides and Ozonationmentioning

confidence: 99%

Section: Detergents and Surfactantsmentioning

confidence: 99%

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Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Cimolai

2022

Journal of Medical Virology

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Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Zupanc

Zevnik

Filipić

et al. 2023

Ultrasonics Sonochemistry

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Disinfectants against SARS-CoV-2: A Review

Xiao

Yuan

Huang

2022

Viruses

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The pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has emerged as a serious global public health issue. Besides the high transmission rate from individual to individual, indirect transmission from inanimate objects or surfaces poses a more significant threat. Since the start of the outbreak, the importance of respiratory protection, social distancing, and chemical disinfection to prevent the spread of the virus has been the prime focus for infection control. Health regulatory organizations have produced guidelines for the formulation and application of chemical disinfectants to manufacturing industries and the public. On the other hand, extensive literature on the virucidal efficacy testing of microbicides for SARS-CoV-2 has been published over the past year and a half. This review summarizes the studies on the most common chemical disinfectants and their virucidal efficacy against SARS-CoV-2, including the type and concentration of the chemical disinfectant, the formulation, the presence of excipients, the exposure time, and other critical factors that determine the effectiveness of chemical disinfectants. In this review, we also critically appraise these disinfectants and conduct a discussion on the role they can play in the COVID-19 pandemic.

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Inactivation of replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on common surfaces by disinfectants

Cited by 4 publications

References 11 publications

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Disinfectants against SARS-CoV-2: A Review

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