Inactivation of Staphyloccus Bacteriophage by Methylene Blue.

Schultz, E. W.

doi:10.3181/00379727-26-4158

Cited by 39 publications

(15 citation statements)

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“…The lack of toxicity of this dye and the burgeoning interest in chemotherapy led to its use in a range of diseases [13]. However, its photoantimicrobial potential was not reported until -ironically -the same year as Fleming's epochmaking publication [14]. However, between 1928 and the clinical introduction of IG Farben's Prontosil in the late 1930s, methylene blue had been shown to be bactericidal, virucidal and antiprotozoal on illumination [14,15].…”

Section: Photoantimicrobial Chemotherapy (Pact [8])mentioning

confidence: 99%

Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery

Wainwright

McLean

2017

Dyes and Pigments

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Section: Photoantimicrobial Chemotherapy (Pact [8])mentioning

confidence: 99%

Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery

Wainwright

McLean

2017

Dyes and Pigments

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“…The sensitivity of viruses to photodynamic procedures was reported in the 1930s [11,12] but only within the last 30 years, with the development of new active molecules, namely photosensitizers (PS), and an increment of light technologies (lasers, LED, portability, etc. ), have photodynamic techniques for the inactivation of viruses received growing attention [13].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Inactivation of Mammalian Viruses and Bacteriophages

Costa

Faustino

Neves

et al. 2012

Viruses

200

205

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Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i) summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii) discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.

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“…The sensitivity of viruses to photodynamic inactivation has been reported as early as in the 1930s (Schultz and Krueger, 1928). Photodynamic inactivation has been clinically applied in treating skin and mucous viral lesions caused by herpes viruses (Felber et al, 1973) and papillomaviruses (Smetana et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Effect of some Phthalocyanines on Enveloped and Naked Viruses

Nikolaeva-Glomb¹,

Mukova²,

Nikolova³

et al. 2017

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Activity of three photosensitizing phthalocyanine derivatives was tested for photodynamic inactivation towards two coated and two non-enveloped viruses - bovine viral diarrhea virus (BVDV), influenza virus A(H3N2), poliovirus type 1 (PV-1) and human adenovirus type 5 (HAdV5). In the case of coated viruses, a combination of virucidal and irradiation effects was registered by octa-methylpyridyloxy-substituted Ga phthalocyanine (Ga8) toward BVDV, whereas tetra-methylpyridyloxy-substituted Ga phthalocyanine (Ga4) revealed a marked photoinactivation only. No such effect was observed towards influenza A virus. In contrast, the photoinactivating potential of Ga4 and Ga8 marked very high values on naked viruses, especially on HAdV5, at which both the virucidal as well as the irradiation effects became combined.

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Inactivation of Staphyloccus Bacteriophage by Methylene Blue.

Cited by 39 publications

References 0 publications

Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery

Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery

Photodynamic Inactivation of Mammalian Viruses and Bacteriophages

Photodynamic Effect of some Phthalocyanines on Enveloped and Naked Viruses

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