Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits

King, Jennifer L.; Miller, Rita J.; Blue, James P.; O’Brien, William D.; Erdman, John W.

doi:10.1016/j.nutres.2009.05.001

Cited by 48 publications

(35 citation statements)

References 26 publications

(50 reference statements)

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“…The rabbits had been on a special fatty diet. 23 The basal diet contained 10% fat, 1% cholesterol, 0.11% Mg, 14% protein and 54% carbohydrates (Catalog No. 1811279, 5TZB, Purina Test Diet, Richmond, IN).…”

Section: B Liver Samplesmentioning

confidence: 99%

Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

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Quantitative ultrasound (QUS) is an imaging technique that can be used to quantify tissue microstructure giving rise to scattered ultrasound. Other ultrasonic properties, e.g., sound speed and attenuation, of tissues have been estimated versus temperature elevation and found to have a dependence with temperature. Therefore, it is hypothesized that QUS parameters may be sensitive to changes in tissue microstructure due to temperature elevation. Ultrasonic backscatter experiments were performed on tissue-mimicking phantoms and freshly excised rabbit and beef liver samples. The phantoms were made of agar and contained either mouse mammary carcinoma cells (4T1) or chinese hamster ovary cells (CHO) as scatterers. All scatterers were uniformly distributed spatially at random throughout the phantoms. All the samples were scanned using a 20-MHz single-element f/3 transducer. Quantitative ultrasound parameters were estimated from the samples versus increases in temperature from 37C to 50 C in 1 C increments. Two QUS parameters were estimated from the backscatter coefficient [effective scatterer diameter (ESD) and effective acoustic concentration (EAC)] using a spherical Gaussian scattering model. Significant increases in ESD and decreases in EAC of 20%-40% were observed in the samples over the range of temperatures examined. The results of this study indicate that QUS parameters are sensitive to changes in temperature. Gaussian scattering model k wavelength Z 0 acoustic impedance of the surrounding medium Z acoustic impedance of the scatterers q density of the sample

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Section: B Liver Samplesmentioning

confidence: 99%

Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

Self Cite

View full text Add to dashboard Cite

show abstract

“…The rabbits had been on a special fatty diet. 41 The basal diet contained 10% fat, 1% cholesterol, 0.11% Mg, 14% protein, and 54% carbohydrates (Catalog No. 1811279, 5TZB, Purina Test Diet, Richmond, IN).…”

Section: B Liver Samplesmentioning

confidence: 99%

Time domain attenuation estimation method from ultrasonic backscattered signals

Ghoshal

Oelze

2012

The Journal of the Acoustical Society of America

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Ultrasonic attenuation is important not only as a parameter for characterizing tissue but also for compensating other parameters that are used to classify tissues. Several techniques have been explored for estimating ultrasonic attenuation from backscattered signals. In the present study, a technique is developed to estimate the local ultrasonic attenuation coefficient by analyzing the time domain backscattered signal. The proposed method incorporates an objective function that combines the diffraction pattern of the source/receiver with the attenuation slope in an integral equation. The technique was assessed through simulations and validated through experiments with a tissue mimicking phantom and fresh rabbit liver samples. The attenuation values estimated using the proposed technique were compared with the attenuation estimated using insertion loss measurements. For a data block size of 15 pulse lengths axially and 15 beamwidths laterally, the mean attenuation estimates from the tissue mimicking phantoms were within 10% of the estimates using insertion loss measurements. With a data block size of 20 pulse lengths axially and 20 beamwidths laterally, the error in the attenuation values estimated from the liver samples were within 10% of the attenuation values estimated from the insertion loss measurements.

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“…There is, furthermore, much evidence that hypomagnesaemia also plays a signi fi cant role in the pathogenesis of cardiovascular diseases and that a high serum magnesium level may retard the development and/or acceleration of arterial calci fi cation and, subsequently, atherosclerosis in ESRD patients. Many experimental studies in animal models have clearly shown a relationship of low Mg with vascular calci fi cation and atherosclerotic lesions [ 96,[112][113][114] .…”

Section: Arterial Calci Fi Cations Atherosclerosismentioning

confidence: 99%