Inadequate treatment of syphilis in pregnancy

Syphilis in adults

“…66 There are controversies surrounding treatments of pregnant women with a single dose of benzathine penicillin as failures has been reported. [67][68][69] Although a single dose may be effective, 70 71 some prefer to treat pregnant women with two to three doses of benzathine penicillin at weekly intervals. 68 In one study treatment of pregnant women using a single dose benzathine penicillin improved pregnancy outcome but the risk of adverse outcome remained high when compared with uninfected mothers, 31 but these result were not found in another study.…”

“…[67][68][69] Although a single dose may be effective, 70 71 some prefer to treat pregnant women with two to three doses of benzathine penicillin at weekly intervals. 68 In one study treatment of pregnant women using a single dose benzathine penicillin improved pregnancy outcome but the risk of adverse outcome remained high when compared with uninfected mothers, 31 but these result were not found in another study. 70 In HIV positive patients, single dose benzathine penicillin for early syphilis is effective with up to 1 year follow up.…”

Congenital Syphilis Revisited

“…13 Except for the few cases with snuf¬ fles or classic cutaneous lesions, the remaining clinical signs were not spe¬ cific for syphilis. Moreover, we found that prematurity and low birth weight may herald the diagnosis in otherwiseasymptomatic infants.…”

Congenital Syphilis After Treatment of MaternalSyphilis With a Penicillin Regimen ExceedingCDC Guidelines

“…[1][2][3] Although some of these case reports probably represent congenital syphilis occurring as a result of undetected maternal reinfection after treatment, clinicians should recognize that penicillin regimens used to treat syphilis are not 100% curative. 4 We …”